120 Publications (Page 4 of 5)
2006
P4-262: Thyroid hormone treatment decreases amyloid-beta levels in brain of transgenic mice
Kao, Patricia F⋅Schultz, James J⋅Lamb, Bruce T and O’Barr, Stephen A
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, vol. 2, (no. 3), pp. S593, 2006. | Journal Article
2005
Reductions in beta-amyloid concentrations in vivo by the gamma-secretase inhibitors BMS-289948 and BMS-299897.
Anderson, Jeffery J⋅Holtz, Greg⋅Baskin, Patricia P⋅Turner, Mary⋅Rowe, Blake⋅Wang, Bowei⋅Kounnas, Maria Z⋅Lamb, Bruce T⋅Barten, Donna⋅Felsenstein, Kevin⋅McDonald, Ian⋅Srinivasan, Kumar⋅Munoz, Ben and Wagner, Steven L
Biochemical pharmacology, vol. 69, (no. 4), pp. 689-98, 2005/Feb/15. | Journal Article
 
The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours
Rubin, Edward M⋅Nickerson, Michael L⋅Behringer, Richard R⋅Coveney, Douglas⋅Schmidt, Laura S⋅Lamb, Bruce T⋅Bhattacharya, Chitralekha⋅Capel, Blanche⋅Matin, Angabin⋅Nadeau, Joseph H⋅Youngren, Kirsten K⋅Deng, Jian Min⋅Peng, Xiaoning⋅Youngren, Kirsten K⋅Coveney, Douglas⋅Peng, Xiaoning⋅Bhattacharya, Chitralekha⋅Schmidt, Laura S⋅Nickerson, Michael⋅Lamb, Bruce⋅Deng, Jian M⋅Behringer, Richard R⋅Capel, Blanche⋅Rubin, Edward M⋅Nadeau, Joseph and Matin, Angabin
Nature, vol. 435, (no. 7040), pp. 360-364, 2005. | Journal Article
2004
Altered Amyloid-beta Metabolism and Deposition in Genomic-based beta-Secretase Transgenic Mice
Chiocco, Matthew J⋅Kulnane, Laura S⋅Younkin, Linda⋅Younkin, Steve⋅Evin, Genevieve and Lamb, Bruce
Journal of Biological Chemistry, vol. 279, (no. 50), pp. 52535-52542, 2004. | Journal Article
 
Altered Amyloid-β Metabolism and Deposition in Genomic-based β-Secretase Transgenic Mice
Chiocco, Matthew J⋅Kulnane, Laura Shapiro⋅Younkin, Linda⋅Younkin, Steve⋅Evin, Geneviève and Lamb, Bruce T
The Journal of biological chemistry, vol. 279, (no. 50), pp. 52542, 2004-Dec-10. | Journal Article
 
Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease.
Yu, W H⋅Kumar, A⋅Peterhoff, C⋅Shapiro Kulnane, L⋅Uchiyama, Y⋅Lamb, Bruce T⋅Cuervo, Ana Maria and Nixon, Ralph A
The international journal of biochemistry & cell biology, vol. 36, (no. 12), pp. 2531-40, 2004/Dec. | Journal Article
 
Functional and morphological alterations in compound transgenic mice overexpressing Cu/Zn superoxide dismutase and amyloid precursor protein [correction].
Harris-Cerruti, Catherine⋅Kamsler, Ariel⋅Kaplan, Batia⋅Lamb, Bruce T⋅Segal, Menahem and Groner, Yoram
The European journal of neuroscience, vol. 19, (no. 5), pp. 1174-90, 2004/Mar. | Journal Article
 
Functional and morphological alterations in compound transgenic mice overexpreszing Cu/Zn superoxide dismutaze and amyloid precursor protein
Harris-Cerruti, C.⋅Kamsler, A.⋅Kaplan, B.⋅Lamb, Bruce⋅Segal, M. and Groner, Yoram
European Journal of Neuroscience, vol. 19, (no. 5), pp. 1174-1190, 2004. | Journal Article
 
Independent effects of APOE on cholesterol metabolism and brain A² levels in an Alzheimer disease mouse model
Mann, Karen M⋅Thorngate, Fayanne E⋅Katoh-Fukui, Yuko⋅Hamanaka, Hiroki⋅Williams, David L⋅Fujita, Shinobu and Lamb, Bruce T
Human Molecular Genetics, vol. 13, (no. 17), pp. 1959-68, Sep 1, 2004. | Journal Article
 
Independent effects of APOE on cholesterol metabolism and brain A beta levels in an Alzheimer disease mouse model
Mann, Karen M⋅Thorngate, Fayanne E⋅Katoh-Fukui, Yuko⋅Hamanaka, Hiroki⋅Williams, David L⋅Fujita, Shinobu and Lamb, Bruce
Human Molecular Genetics, vol. 13, (no. 17), pp. 1959-1968, 2004. | Journal Article
 
Independent effects of APOE on cholesterol metabolism and brain Abeta levels in an Alzheimer disease mouse model.
Mann, Karen M⋅Thorngate, Fayanne E⋅Katoh-Fukui, Yuko⋅Hamanaka, Hiroki⋅Williams, David L⋅Fujita, Shinobu and Lamb, Bruce T
Human molecular genetics, vol. 13, (no. 17), pp. 1959-68, 2004/Sep/1. | Journal Article
 
P2-117 Genetics modifiers of beta-amyloid metabolism and deposition in the mouse
Lamb, Bruce T⋅Ryman, Davis C⋅Gao, Yuan and Kulnane, Laura S
Neurobiology of Aging, vol. 25, pp. S258, 2004. | Journal Article
 
The role of nitric oxide in the pathogenesis of brain lesions during the development of Alzheimer's disease.
Seyidova, Dilara⋅Aliyev, Ali⋅Rzayev, Nizami⋅Obrenovich, Mark⋅Lamb, Bruce T⋅Smith, Mark A⋅de la Torre, Jack C⋅Perry, George and Aliev, Gjumrakch
In vivo (Athens, Greece), vol. 18, (no. 3), pp. 325-33, 2004 May-Jun. | Journal Article
2003
Alterations in beta -amyloid production and deposition in brain regions of two transgenic models
Lehman, EJH⋅Kulnane, LS and Lamb, Bruce
Neurobiology of Aging, vol. 24, (no. 5), pp. 645-653, 2003. | Journal Article
 
Genetic background regulates [beta]-amyloid precursor protein processing and [beta]-amyloid deposition in the mouse
Lehman, Emily J⋅Kulnane, Laura S⋅Gao, Yuan⋅Petriello, Michelle C⋅Pimpis, Karen M⋅Younkin, Linda⋅Dolios, Georgia⋅Wang, Rong⋅Younkin, Steven G and Lamb, Bruce T
Human Molecular Genetics, vol. 12, (no. 22), pp. 2949-56, Nov 15, 2003. | Journal Article
 
Genetic background regulates beta-amyloid precursor protein processing and beta-amyloid deposition in the mouse
Lehman, Emily J H⋅Kulnane, Laura Shapiro⋅Gao, Yuan⋅Petriello, Michelle C⋅Pimpis, Karen M⋅Younkin, Linda⋅Dolios, Georgia⋅Wang, Rong⋅Younkin, Steven G and Lamb, Bruce T
Human molecular genetics, vol. 12, (no. 22), pp. 2949, 2003-Nov-15. | Journal Article
 
Genetic background regulates ß-amyloid precursor protein processing and ß-amyloid deposition in the mouse
Lehman, E.J.H., Kulnane, L.S., Gao, Y., Petriello, M.C., Pimpis, K.M., Younkin, L., Dolios, G., Wang, R., Younkin, S.G., and B.T. Lamb and Lamb, Bruce T
(pp. 2949-2956). 2003
 
Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice.
Aliev, Gjumrakch⋅Seyidova, Dilara⋅Lamb, Bruce T⋅Obrenovich, Mark E⋅Siedlak, Sandra L⋅Vinters, Harry V⋅Friedland, Robert P⋅La Manna, Joseph C⋅Smith, Mark A and Perry, George
Neurological research, vol. 25, (no. 6), pp. 665-74, 2003/Sep. | Journal Article
2002
Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice.
Aliev, Gjumrakch⋅Seyidova, Dilara⋅Neal, Maxwell L⋅Shi, Jiong⋅Lamb, Bruce T⋅Siedlak, Sandra L⋅Vinters, Harry V⋅Head, Elizabeth⋅Perry, George⋅La Manna, Joseph C⋅Friedland, Robert P and Cotman, Carl W
Annals of the New York Academy of Sciences, vol. 977, pp. 45-64, 2002/Nov. | Journal Article
 
Rapid and efficient detection of transgene homozygosity by FISH of mouse fibroblasts.
Kulnane, Laura S⋅Lehman, Emily J⋅Hock, Brian J⋅Tsuchiya, Karen D and Lamb, Bruce T
Mammalian genome : official journal of the International Mammalian Genome Society, vol. 13, (no. 4), pp. 223-6, 2002/Apr. | Journal Article
 
The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer's disease.
Aliev, Gjumrakch⋅Smith, Mark A⋅Seyidov, Dilara⋅Neal, Maxwell L⋅Lamb, Bruce T⋅Nunomura, Akihiko⋅Gasimov, Eldar K⋅Vinters, Harry V⋅Perry, George⋅La Manna, Joseph C and Friedland, Robert P
Brain pathology (Zurich, Switzerland), vol. 12, (no. 1), pp. 21-35, 2002/Jan. | Journal Article
2001
Neuropathological Characterization of Mutant Amyloid Precursor Protein Yeast Artificial Chromosome Transgenic Mice
Kulnane, Laura S and Lamb, Bruce
Neurobiology of Disease, vol. 8, (no. 6), pp. 982-992, 2001. | Journal Article
 
Transgenic mouse models of Alzheimer's disease
Hock, Brian J and Lamb, Bruce
Trends in Genetics, vol. 17, (no. 10), pp. S7-S12, 2001. | Journal Article
2000
Atherosclerotic-like changes of the wall of cerebral microvessels in transgenic mice overexpressing amyloid β
Aliev, Gjumrakch⋅Shi, Jiong⋅LaManna, Joseph C⋅Lamb, Bruce T and Friedland, Robert P
Neurobiology of Aging, vol. 21, pp. 267, 2000. | Journal Article
 
Mitochondrial abnormalities mark vulnerable neurons in APP YAC transgenic mice
Aliev, Gjumrakch⋅Shi, Jiong⋅LaManna, Joseph C⋅Friedland, Robert P and Lamb, Bruce T
Neurobiology of Aging, vol. 21, pp. 267, 2000. | Journal Article