9 Publications
2019
A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78
Ambrose, Andrew J⋅Ambrose, Andrew J⋅Zerio, Christopher J⋅Zerio, Christopher J⋅Sivinski, Jared⋅Sivinski, Jared⋅Schmidlin, Cody J⋅Schmidlin, Cody J⋅Shi, Taoda⋅Shi, Taoda⋅Ross, Alison B⋅Ross, Alison B⋅Widrick, Kimberly J⋅Widrick, Kimberly J⋅Johnson, Steven M⋅Johnson, Steven M⋅Zhang, Donna D⋅Zhang, Donna D⋅Chapman, Eli and Chapman, Eli
Bioorganic & Medicinal Chemistry Letters, vol. 29, (no. 14), pp. 1693, 2019-07-15. | Journal Article
 
Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections
Washburn, Alex⋅Washburn, Alex⋅Washburn, Alex⋅Abdeen, Sanofar⋅Abdeen, Sanofar⋅Abdeen, Sanofar⋅Ovechkina, Yulia⋅Ovechkina, Yulia⋅Ovechkina, Yulia⋅Ray, Anne-Marie⋅Ray, Anne-Marie⋅Ray, Anne-Marie⋅Stevens, Mckayla⋅Stevens, Mckayla⋅Stevens, Mckayla⋅Chitre, Siddhi⋅Chitre, Siddhi⋅Chitre, Siddhi⋅Sivinski, Jared⋅Sivinski, Jared⋅Sivinski, Jared⋅Park, Yangshin⋅Park, Yangshin⋅Park, Yangshin⋅Johnson, James⋅Johnson, James⋅Johnson, James⋅Johnson, Steven M⋅Hoang, Quyen Q⋅Hoang, Quyen Q⋅Hoang, Quyen Q⋅Chapman, Eli⋅Chapman, Eli⋅Chapman, Eli⋅Parish, Tanya⋅Parish, Tanya⋅Parish, Tanya⋅Johnson, Steven M and Johnson, Steven M
Bioorganic & Medicinal Chemistry Letters, vol. 29, (no. 13), pp. 1672, 2019-07-01. | Journal Article
 
HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules
Stevens, Mckayla⋅Stevens, Mckayla⋅Abdeen, Sanofar⋅Abdeen, Sanofar⋅Salim, Nilshad⋅Salim, Nilshad⋅Ray, Anne-Marie⋅Ray, Anne-Marie⋅Washburn, Alex⋅Washburn, Alex⋅Chitre, Siddhi⋅Chitre, Siddhi⋅Sivinski, Jared⋅Sivinski, Jared⋅Park, Yangshin⋅Park, Yangshin⋅Hoang, Quyen Q⋅Hoang, Quyen Q⋅Chapman, Eli⋅Chapman, Eli⋅Johnson, Steven M and Johnson, Steven M
Bioorganic & Medicinal Chemistry Letters, vol. 29, (no. 9), pp. 1112, 2019-05-01. | Journal Article
2018
Hydroxybiphenylamide GroEL/ES Inhibitors Are Potent Antibacterials against Planktonic and Biofilm Forms of Staphylococcus aureus
Kunkle, Trent⋅Kunkle, Trent⋅Abdeen, Sanofar⋅Abdeen, Sanofar⋅Salim, Nilshad⋅Salim, Nilshad⋅Ray, Anne-Marie⋅Ray, Anne-Marie⋅Stevens, Mckayla⋅Stevens, Mckayla⋅Ambrose, Andrew J⋅Ambrose, Andrew J⋅Victorino, José⋅Victorino, José⋅Park, Yangshin⋅Park, Yangshin⋅Hoang, Quyen Q⋅Hoang, Quyen Q⋅Chapman, Eli⋅Chapman, Eli⋅Johnson, Steven M and Johnson, Steven M
Journal of medicinal chemistry, vol. 61, (no. 23), pp. 10664, 2018-Dec-13. | Journal Article
 
Sulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA)
Abdeen, Sanofar⋅Abdeen, Sanofar⋅Abdeen, Sanofar⋅Kunkle, Trent⋅Kunkle, Trent⋅Kunkle, Trent⋅Salim, Nilshad⋅Salim, Nilshad⋅Salim, Nilshad⋅Ray, Anne-Marie⋅Ray, Anne-Marie⋅Ray, Anne-Marie⋅Mammadova, Najiba⋅Mammadova, Najiba⋅Mammadova, Najiba⋅Summers, Corey⋅Summers, Corey⋅Summers, Corey⋅Stevens, Mckayla⋅Stevens, Mckayla⋅Stevens, Mckayla⋅Ambrose, Andrew J⋅Ambrose, Andrew⋅Ambrose, Andrew J⋅Park, Yangshin⋅Park, Yangshin⋅Park, Yangshin⋅Schultz, Peter G⋅Schultz, Peter G⋅Schultz, Peter G⋅Horwich, Arthur L⋅Horwich, Arthur L⋅Horwich, Arthur L⋅Hoang, Quyen Q⋅Hoang, Quyen⋅Hoang, Quyen Q⋅Chapman, Eli⋅Chapman, Eli⋅Chapman, Eli⋅Johnson, Steven M⋅Johnson, Steven M and Johnson, Steven M
Journal of medicinal chemistry, vol. 61, (no. 16), pp. 7357, 2018-Aug-23. | Journal Article
2017
Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors
Connelly, Stephen⋅Mortenson, David E⋅Choi, Sungwook⋅Wilson, Ian A⋅Powers, Evan T⋅Kelly, Jeffery W and Johnson, Steven M
Bioorganic & Medicinal Chemistry Letters, vol. 27, (no. 15), pp. 3449, 2017-08-01. | Journal Article
2016
GroEL/ES inhibitors as potential antibiotics
Abdeen, Sanofar⋅Abdeen, Sanofar⋅Salim, Nilshad⋅Salim, Nilshad⋅Mammadova, Najiba⋅Mammadova, Najiba⋅Summers, Corey M⋅Summers, Corey M⋅Frankson, Rochelle⋅Frankson, Rochelle⋅Ambrose, Andrew J⋅Ambrose, Andrew J⋅Anderson, Gregory G⋅Anderson, Gregory G⋅Schultz, Peter G⋅Schultz, Peter G⋅Horwich, Arthur L⋅Horwich, Arthur L⋅Chapman, Eli⋅Chapman, Eli⋅Johnson, Steven M and Johnson, Steven M
Bioorganic & Medicinal Chemistry Letters, vol. 26, (no. 13), pp. 3134, 2016-07-01. | Journal Article
 
Targeting the HSP60/10 chaperonin systems of Trypanosoma brucei as a strategy for treating African sleeping sickness
Abdeen, Sanofar⋅Abdeen, Sanofar⋅Salim, Nilshad⋅Salim, Nilshad⋅Mammadova, Najiba⋅Mammadova, Najiba⋅Summers, Corey M⋅Summers, Corey M⋅Goldsmith-Pestana, Karen⋅Goldsmith-Pestana, Karen⋅McMahon-Pratt, Diane⋅McMahon-Pratt, Diane⋅Schultz, Peter G⋅Schultz, Peter G⋅Horwich, Arthur L⋅Horwich, Arthur L⋅Chapman, Eli⋅Chapman, Eli⋅Johnson, Steven M and Johnson, Steven M
Bioorganic & Medicinal Chemistry Letters, vol. 26, (no. 21), pp. 5253, 2016-11-01. | Journal Article
2014
A biochemical screen for GroEL/GroES inhibitors
Johnson, Steven M⋅Johnson, Steven M⋅Sharif, Orzala⋅Sharif, Orzala⋅Mak, Puiying A⋅Mak, Puiying Annie⋅Wang, Hsiao-Ting⋅Wang, Hsiao-Ting⋅Engels, Ingo H⋅Engels, Ingo H⋅Brinker, Achim⋅Brinker, Achim⋅Schultz, Peter G⋅Schultz, Peter G⋅Horwich, Arthur L⋅Horwich, Arthur L⋅Chapman, Eli and Chapman, Eli
Bioorganic & Medicinal Chemistry Letters, vol. 24, (no. 3), pp. 789, 2014-02-01. | Journal Article