The primary focus of my research is to develop anti-inflammatory therapies for the treatment of neurodegenerative diseases, including ischemic stroke and multiple sclerosis (MS), and to further dissect the molecular mechanisms underlying the protective effects of these treatments. With regard to ischemic stroke research, my lab is interested in developing anti-inflammatory therapies that can be combined with tissue plasminogen activator (tPA) treatment, the only FDA-approved therapy for ischemic stroke that functions to restore cerebral blood flow by dissolving blood clots but does not offer any protective effects for ischemia-induced neuroinflammation.
Research Projects
- Ischemic Stroke Project
- Multiple Sclerosis (MS) Project
- Alzheimer's Disease (AD) Project
Research Focus:
- Neuroinflammation plays a pivotal role in the pathogenesis of many CNS disorders, including ischemic stroke and multiple sclerosis (MS). The primary focus of our research is to understand cellular and molecular mechanisms of ischemic stroke and MS-evoked neuroinflammation using animal models of transient middle cerebral ischemia/reperfusion (tMCAO/R) and experimental autoimmune encephalomyelitis (EAE), respectively.
