63 Publications (Page 1 of 3)
2022
A new Down syndrome rat model races forward
Trends in Genetics. | Journal Article
 
Increased dosage and treatment time of Epigallocatechin-3-gallate (EGCG) negatively affects skeletal parameters in normal mice and Down syndrome mouse models
Raza, Jamal⋅LaCombe, Jonathan⋅Patel, Roshni⋅Blackwell, Matthew⋅Thomas, Jared R⋅Sloan, Kourtney⋅Wallace, Joseph M and Roper, Randall J
PLOS ONE. | Journal Article
2021
Current Analysis of Skeletal Phenotypes in Down Syndrome
Current Osteoporosis Reports. | Journal Article
2020
Influence of allelic differences in Down syndrome
Roper, Randall J⋅Roper, Randall J⋅Hawley, Laura⋅Hawley, Laura⋅Goodlett, Charles R and Goodlett, Charles R
Progress in brain research, vol. 251, pp. 29, 2020-00-00. | Journal Article
 
Interaction of sexual dimorphism and gene dosage imbalance in skeletal deficits associated with Down syndrome
Thomas, Jared R⋅LaCombe, Jonathan⋅Long, Rachel⋅Lana-Elola, Eva⋅Watson-Scales, Sheona⋅Wallace, Joseph M⋅Fisher, Elizabeth M.C⋅Tybulewicz, Victor L.J and Roper, Randall J
Bone. | Journal Article
 
Skeletal dynamics of Down syndrome: A developing perspective
LaCombe, Jonathan M. and Roper, Randall J.
Bone, vol. 133, pp. 115215. | Journal Article
2019
Clinical identification of feeding and swallowing disorders in 0–6 month old infants with Down syndrome
Stanley, Maria A⋅Stanley, Maria A⋅Stanley, Maria A⋅Shepherd, Nicole⋅Shepherd, Nicole⋅Shepherd, Nicole⋅Duvall, Nichole⋅Duvall, Nichole⋅Duvall, Nichole⋅Jenkinson, Sandra B⋅Jenkinson, Sandra B⋅Jenkinson, Sandra B⋅Jalou, Hasnaa E⋅Jalou, Hasnaa E⋅Jalou, Hasnaa E⋅Givan, Deborah C⋅Givan, Deborah C⋅Givan, Deborah C⋅Steele, Gregory H⋅Steele, Gregory H⋅Steele, Gregory H⋅Davis, Charlene⋅Davis, Charlene⋅Davis, Charlene⋅Bull, Marilyn J⋅Bull, Marilyn J⋅Bull, Marilyn J⋅Watkins, Donna U⋅Watkins, Donna U⋅Watkins, Donna U⋅Roper, Randall J⋅Roper, Randall J and Roper, Randall J
American Journal of Medical Genetics Part A, vol. 179, (no. 2), pp. 182, February 2019. | Journal Article
 
Down syndrome mouse models have an abnormal enteric nervous system
Schill, Ellen M.⋅Wright, Christina M.⋅Jamil, Alisha⋅LaCombe, Jonathan M.⋅Roper, Randall J. and Heuckeroth, Robert O.
JCI Insight. | Journal Article
 
Usage of and attitudes about green tea extract and Epigallocathechin-3-gallate (EGCG) as a therapy in individuals with Down syndrome
Long, Rachel⋅Long, Rachel⋅Drawbaugh, Montana L⋅Drawbaugh, Montana L⋅Davis, Charlene M⋅Davis, Charlene M⋅Goodlett, Charles R⋅Goodlett, Charles R⋅Williams, Jane R⋅Williams, Jane R⋅Roper, Randall J and Roper, Randall J
Complementary Therapies in Medicine, vol. 45, pp. 241, August 2019. | Journal Article
2017
Epigallocatechin-3-gallate (EGCG) consumption in the Ts65Dn model of down syndrome fails to improve behavioral deficits and is detrimental to skeletal phenotypes
Stringer, Megan⋅Stringer, M.⋅Stringer, Megan⋅Abeysekera, Irushi⋅Abeysekera, I.⋅Abeysekera, Irushi⋅Thomas, J.⋅Thomas, Jared⋅Thomas, Jared⋅LaCombe, J.⋅LaCombe, Jonathan⋅LaCombe, Jonathan⋅Stancombe, Kailey⋅Stancombe, Kailey⋅Stancombe, K.⋅Stewart, Robert⋅Stewart, Robert⋅Stewart, R.J.⋅Dria, K.J.⋅Dria, Karl⋅Dria, Karl⋅Wallace, Joseph⋅Wallace, J.M.⋅Wallace, Joseph⋅Goodlett, Charles⋅Goodlett, Charles⋅Goodlett, C.R.⋅Roper, Randall⋅Roper, R.J. and Roper, Randall
Physiology and Behavior, vol. 177, pp. 230-241. | Journal Article
 
Targeting trisomic treatments: optimizing Dyrk1a inhibition to improve Down syndrome deficits
Stringer, Megan⋅Stringer, Megan⋅Goodlett, Charles R⋅Goodlett, Charles R.⋅Roper, Randall J and Roper, Randall J.
Molecular Genetics & Genomic Medicine, vol. 5, pp. 451–465. | Journal Article
2016
Differential effects of Epigallocatechin-3-gallate containing supplements on correcting skeletal defects in a Down syndrome mouse model
Abeysekera, Irushi⋅Abeysekera, I.⋅Thomas, J.⋅Thomas, Jared⋅Georgiadis, Taxiarchis M⋅Georgiadis, T.M.⋅Berman, A.G.⋅Berman, Alycia G⋅Hammond, Max A⋅Hammond, M.A.⋅Dria, Karl J⋅Dria, K.J.⋅Wallace, Joseph M⋅Wallace, J.M.⋅Roper, R.J. and Roper, Randall J
Molecular Nutrition and Food Research, vol. 60, pp. 717-726. | Journal Article
 
Influence of prenatal EGCG treatment and Dyrk1a dosage reduction on craniofacial features associated with Down syndrome
McElyea, S.D.⋅McElyea, Samantha D⋅Starbuck, John M⋅Starbuck, J.M.⋅Tumbleson-Brink, Danika M⋅Tumbleson-Brink, D.M.⋅Harrington, Emily⋅Harrington, E.⋅Blazek, J.D.⋅Blazek, Joshua D⋅Ghoneima, A.⋅Ghoneima, Ahmed⋅Kula, Katherine⋅Kula, K.⋅Roper, Randall J and Roper, R.J.
Human Molecular Genetics, vol. 25, pp. 4856-4869. | Journal Article
2015
Abnormal mineralization of the Ts65Dn Down syndrome mouse appendicular skeleton begins during embryonic development in a Dyrk1a-independent manner.
Blazek, Joshua D⋅Malik, Ahmed M⋅Tischbein, Maeve⋅Arbones, Maria L⋅Moore, Clara S and Roper, Randall J
Mechanisms of development, vol. 136, pp. 133-142, May 2015. | Journal Article
 
Low dose EGCG treatment beginning in adolescence does not improve cognitive impairment in a Down syndrome mouse model.
Stringer, Megan⋅Abeysekera, Irushi⋅Dria, Karl J⋅Roper, Randall J and Goodlett, Charles R
Pharmacology, biochemistry, and behavior, vol. 138, pp. 70-79, November 2015. | Journal Article
 
Obstructive sleep apnea in young infants with Down syndrome evaluated in a Down syndrome specialty clinic.
Goffinski, Alida⋅Goffinski, Alida⋅Stanley, Maria A⋅Stanley, Maria A⋅Shepherd, Nicole⋅Shepherd, Nicole⋅Duvall, Nichole⋅Duvall, Nichole⋅Jenkinson, Sandra B⋅Jenkinson, Sandra B⋅Davis, Charlene⋅Davis, Charlene⋅Bull, Marilyn J⋅Bull, Marilyn J⋅Roper, Randall J and Roper, Randall J
American journal of medical genetics. Part A, vol. 167A, (no. 2), pp. 324-330, February 2015. | Journal Article
 
Rescue of the abnormal skeletal phenotype in Ts65Dn Down syndrome mice using genetic and therapeutic modulation of trisomic Dyrk1a.
Blazek, Joshua D⋅Abeysekera, Irushi⋅Li, Jiliang and Roper, Randall J
Human molecular genetics, vol. 24, (no. 20), pp. 5687-5696, October 15, 2015. | Journal Article
2013
Commonality in Down and fetal alcohol syndromes.
Solzak, Jeffrey P⋅Liang, Yun⋅Zhou, Feng C and Roper, Randall
Birth defects research. Part A, Clinical and molecular teratology, vol. 97, (no. 4), pp. 187-97, 2013/Apr. | Journal Article
 
Non-trisomic homeobox gene expression during craniofacial development in the Ts65Dn mouse model of Down syndrome.
Billingsley, Cherie N⋅Allen, Jared R⋅Baumann, Douglas D⋅Deitz, Samantha L⋅Blazek, Joshua D⋅Newbauer, Abby⋅Darrah, Andrew⋅Long, Brad C⋅Young, Brandon⋅Clement, Mark⋅Doerge, R W and Roper, Randall J
American journal of medical genetics. Part A, vol. 161A, (no. 8), pp. 1866-1874, August 2013. | Journal Article
 
Trying out genes for size: Experiential learning in the high school classroom
Blazek, J.D.⋅Blazek, Joshua⋅Cooper, Gary⋅Cooper, G.L.⋅Judd, Mariah⋅Judd, M.V.⋅Roper, R.J.⋅Roper, Randall⋅Marrs, Kathleen and Marrs, K.A.
American Biology Teacher, vol. 75, pp. 657-662. | Journal Article
2011
Disruption of bone development and homeostasis by trisomy in Ts65Dn Down syndrome mice.
Blazek, Joshua D⋅Gaddy, Anna⋅Meyer, Rachel⋅Roper, Randall and Li, Jiliang
Bone, vol. 48, (no. 2), pp. 275-80, 2011/Feb. | Journal Article
 
Erratum: Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn (Mammalian Genome DOI: 10.1007/s00335-011- 9357-z)
Reinholdt, Laura⋅Reinholdt, L.G.⋅Ding, Yueming⋅Ding, Y.⋅Gilbert, Griffith J⋅Gilbert, G.J.⋅Czechanski, Anne⋅Czechanski, A.⋅Solzak, J.P.⋅Solzak, Jeffrey P⋅Roper, R.J.⋅Roper, Randall J⋅Johnson, M.T.⋅Johnson, Mark T⋅Donahue, Leah R⋅Donahue, L.R.⋅Lutz, Cathleen⋅Lutz, C.⋅Davisson, Muriel T and Davisson, M.T.
Mammalian Genome, vol. 22. | Journal Article
 
Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn
Reinholdt, Laura⋅Ding, Yueming⋅Gilbert, Griffith T⋅Czechanski, Anne⋅Solzak, Jeffrey P⋅Roper, Randall⋅Johnson, Mark T⋅Donahue, Leah R⋅Lutz, Cathleen and Davisson, Muriel T
Mammalian Genome, vol. 22, (no. 11-12), pp. 685-691, 2011. | Journal Article
 
Trisomic and Allelic Differences Influence Phenotypic Variability During Development of Down Syndrome Mice
Deitz, Samantha L and Roper, Randall
Genetics, vol. 189, (no. 4), pp. 1487-95, Dec 2011. | Journal Article
2010
Embryonic and not maternal trisomy causes developmental attenuation in the Ts65Dn mouse model for Down syndrome.
Blazek, Joshua D⋅Billingsley, Cherie N⋅Newbauer, Abby and Roper, Randall
Developmental dynamics : an official publication of the American Association of Anatomists, vol. 239, (no. 6), pp. 1645-53, 2010/Jun. | Journal Article