His expertise is in diabetes mellitus and prediabetes, with research efforts ranging from diabetes prevention to metabolic physiology to diabetes treatment. His overarching focus is on the prevention of diabetes-related complications, particularly cardiovascular disease.
Dr Mather is interested in prevention of diabetes-related complications, particularly diabetes-associated cardiovascular disease. This is reflected in three main avenues of investigation. First, he is involved in studies of diabetes prevention including the longstanding Diabetes Prevention Program Outcomes Study, and an ongoing study of methods to improve diabetes prevention by improving insulin production in prediabetes. Second, he is involved in studies of diabetes treatment, overall aimed at improving metabolic control and where possible assessing the effects of these interventions on diabetes complications. These studies include small local proof-of-principle studies, large multicenter NIH-sponsored clinical trials, and industry-sponsored clinical trials. Third, in partnership with Johnathan Tune, Adam Goodwill, and members of the Tune lab (Department of Cellular and Integrative Metabolism) he pursues studies of the effects of diabetes on cardiovascular disease, and effects of diabetes treatments on cardiovascular outcomes.
- Diabetes and metabolism
- Cardiac disease in diabetes
- Diabetes medicine effects on cardiac diseas