Expertise

Work in our laboratory is focused on two general question:

  • Cardiovascular and Neurological Disease: Subtype-selective modulation of L-type voltage-gated Ca2+ channels
  • Type II Diabetes: What roles do L-type calcium channels play in insulin-secreting cells?

Recent work in my lab has centered on describing the binding site for the BZP diltiazem in the Cav1.2 L-type channel, as well as the Ca2+ binding site in the channel that modulates the affinity for diltiazem and verapamil.

Our current research is focused on the role of Cav1.2 and 1.3 channels in insulin secreting cells.


Subject Areas:

  • metabolism
  • neuroscience

Area of research: Molecular and Cellular Pharmacology


Research: Islet Function and Survival


Aeras: Molecular pharmacology

Affiliations

Professor, Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University

Associate Head, Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University

Associate Professor, Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Nursing and Health Sciences

Professor, Integrative Neuroscience, Graduate School, Purdue University

Adjunct Professor, IUSM West Lafayette, Indiana University School of Medicine

Investigator, Center for Diabetes and Metabolic Diseases, Centers and Institutes, Indiana University School of Medicine

Past Affiliations

Associate Professor, Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University (past)

Associate Professor, Integrative Neuroscience Graduate Program, Graduate School, Purdue University (past)

Assistant Professor, Integrative Neuroscience Graduate Program, Graduate School, Purdue University (past)

Communities
Pharmacology, Pharmacology, Neuroscience, Chemistry, Chemistry, Nursing, Allied Health, Pharmacy
Degrees
PhD, University of Wisconsin-Madison, Pharmacology, 1991
BS, University of Queensland, Australia, 1989
BS, Olivet Nazarene University, 1983
Keywords
medicinal chemistry pharmacy & pharmacology diabetes alzheimer's disease insulin ion channels
Associations
American Diabetes Association
American Society for Pharmacology and Experimental Therapeutics
Biophysical Society