The initial focus of the research is understanding: (1) the cell of origin of HGSC, using lineage tracing in mice, (2) the role of ovary in the development of HGSC, with mouse models and cell lines, (3) the role of DICER or microRNAs in HGSC, and (4) the early genetic and molecular changes driving HGSC, using genomic and genetic approaches.
Subject Area:
- Biochemistry & Molecular Biology.