Dr. Nakshatri's research interests include:
- Understanding the mechanisms of resistance to antiestrogen and chemotherapy in breast cancer. Therapeutic targeting of breast cancer stem cells. Serum biomarkers of cancer progression.
Currently, his group is engaged in six main research projects.
- Mechanisms associated with systemic effects of cancer.
- Heterogeneity in normal and cancer with a focus on cancer stem cell hypothesis.
- Organ-specific metastasis.
- The role of AKT1 isoform in estrogen addiction phenotype of breast cancer.
- Estrogen Receptor signaling in normal breast epithelial cells.
Dr. Nakshatri’s laboratory research interests are on heterogeneity in normal breast, the mechanisms of anti-estrogen resistance and metastasis in breast cancer. Ongoing research in his lab includes elucidating the mechanisms by which the serine/threonine kinase AKT alters estrogen signaling and confers anti-estrogen resistance in breast Cancer.
My interests are in understanding how growth factors/cytokines secreted by cancer cells affect cardiac and skeletal muscle function and aging and to develop circulating microRNAs as biomarkers of systemic effects of cancer.