Expertise

Our lab is focused on the Adenomatous Polyposis Coli (APC) tumor suppressor. To better understand the molecular basis of breast cancer and identify novel therapeutic approaches, the Prosperi laboratory will investigate how APC loss mediates breast tumor development by studying multiple facets of tumor biology.

One aspect we are investigating is the role of APC in mediating therapeutic response in breast cancer.

In addition, we focus our efforts on how APC regulates the development of a polarized epithelium.

My laboratory focuses on a tumor suppressor called Adenomatous Polyposis Coli (APC) in the development and progression of cancer. We are particularly interested in the function of APC that is independent of it’s role in regulation of the Wnt/β-catenin signaling pathway.

Primary Research Areas:

  • Cancer
  • Cellular & Molecular Biology

Research Specialties:

  • Breast cancer
  • Chemotherapy resistance in breast cancer
  • Cell Signaling
  • Cell polarization and three-dimensional morphogenesis

Subject Area:

  • Biochemistry & Molecular Biology
Affiliations

Associate Professor, Vera Bradley Foundation Center for Breast Cancer Research, Centers and Institutes, Indiana University School of Medicine

Associate Professor, IUSM South Bend, Indiana University School of Medicine

Adjunct Associate Professor, Department of Biological Sciences, College of Science, University of Notre Dame

Harper Cancer Research Institute, Notre Dame Research, University of Notre Dame

Past Affiliations

Harper Cancer Research Institute, Notre Dame Research, University of Notre Dame (past)

Adjunct Assistant Professor, Department of Biological Sciences, College of Science, University of Notre Dame (past)
2013

Assistant Professor, Indiana University School of Medicine South Bend, Indiana University School of Medicine

Assistant Professor, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine
2012

Investigator, Vera Bradley Foundation Center for Breast Cancer Research, Centers and Institutes, Indiana University School of Medicine

Melvin and Bren Simon Cancer Center

Assistant Professor, Department of Biochemistry and Molecular Biology

Assistant Professor, School of Medicine

Communities
Biochemistry, Molecular Biology, Oncology, Cellular Biochemistry, Molecular Biochemistry
Degrees
PhD, Ohio State University, Integrated Biomedical Science, 2006
BA, Miami University, Microbiology, 2000
Keywords
cancer biology breast cancer public health