Our lab is focused on the Adenomatous Polyposis Coli (APC) tumor suppressor. To better understand the molecular basis of breast cancer and identify novel therapeutic approaches, the Prosperi laboratory will investigate how APC loss mediates breast tumor development by studying multiple facets of tumor biology.
One aspect we are investigating is the role of APC in mediating therapeutic response in breast cancer.
In addition, we focus our efforts on how APC regulates the development of a polarized epithelium.
My laboratory focuses on a tumor suppressor called Adenomatous Polyposis Coli (APC) in the development and progression of cancer. We are particularly interested in the function of APC that is independent of it’s role in regulation of the Wnt/β-catenin signaling pathway.
Primary Research Areas:
- Cellular & Molecular Biology
- Breast cancer
- Chemotherapy resistance in breast cancer
- Cell Signaling
- Cell polarization and three-dimensional morphogenesis
- Biochemistry & Molecular Biology