Keywords:
- The maintenance of genomic integrity with a focus on DNA helicases and other factors involved in DNA replication, recombination, and repair; the evolution of DNA helicases. The science of fermentation.
We study the molecular basis of genome integrity and genomic instability, with a focus on DNA helicases and their associated proteins. Currently, we have projects focused on the roles of RecQ4 family helicases in DNA inter-strand crosslink (ICL) repair, the regulation of PIF1 helicases by post-translational modifications, and the interplay between these two helicases as it relates to the regulation of telomerase. In the future, we plan to expand our ICL research to other pathways in multiple model organisms/cell lines because upregulation of these pathways is a common therapeutic resistance mechanism used by cancers.
The Bochman lab studies the maintenance of genome integrity, with a primary focus on DNA helicases.
We are interested in the in vitro and in vivo characterization of diverse helicases from bacteria to humans, determining why their dysfunction often leads to disease states, and the evolution and specialization of the various enzymatic activities that helicases possess.
Research Interests:
- Pif1 family helicases
- RecQ family helicases
- Alcohol and fermentation.
Research Interests:
- maintenance of genomic integrity with a focus on DNA helicases and other factors involved in DNA replication, recombination, and repair; the evolution of DNA helicases
Subject Areas:
- Molecular and Cellular Biochemistry
- Biology.
