Her laboratory is focused on regulation of normal and malignant hematopoietic stem cells and identification of biologically relevent targets to enhance transplantation and mitgate disease, respectively.
The overall interests of the O'Leary laboratory are to understand how components of the bone marrow microenvironment (specifically hypoxia/hypoxia sensitive proteins) modify normal/malignant hematopoietic stem cell phenotype, signaling, function, response to therapy, and niche preference.
More specifically, we are interested in low oxygen tension in the niche and the true biology of hematopoietic cells in their native setting.