151 Publications (Page 2 of 7)
2014
Tetrodotoxin-resistant sodium channels in sensory neurons generate slow resurgent currents that are enhanced by inflammatory mediators.
Tan, Zhi YongPiekarz, Andrew DPriest, Birgit TKnopp, Kelly LKrajewski, Jeffrey LMcDermott, Jeff SNisenbaum, Eric S and Cummins, Theodore R
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 34, (no. 21), pp. 7190-7197, May 21, 2014. | Journal Article
2013
Structural Basis for the Modulation of the Neuronal Voltage-Gated Sodium Channel NaV1.6 by Calmodulin
Reddy Chichili, Vishnu PriyankaXiao, YuchengSeetharaman, JCummins, Theodore R and Sivaraman, J
Scientific reports, vol. 3, (no. 1), pp. 2435, 2013-00-00. | Journal Article
 
Voltage-gated sodium channel in grasshopper mice defends against bark scorpion toxin.
Rowe, Ashlee HXiao, YuchengRowe, Matthew PCummins, Theodore R and Zakon, Harold H
Science (New York, N.Y.), vol. 342, (no. 6157), pp. 441-446, October 25, 2013. | Journal Article
2012
Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites.
Ashpole, Nicole MAshpole, Nicole M.Ashpole, Nicole MHerren, Anthony W.Herren, Anthony WHerren, Anthony WGinsburg, Kenneth S.Ginsburg, Kenneth SGinsburg, Kenneth SBrogan, Joseph DBrogan, Joseph DBrogan, Joseph D.Johnson, Derrick E.Johnson, Derrick EJohnson, Derrick ECummins, Theodore RCummins, Theodore RCummins, Theodore R.Bers, Donald MBers, Donald M.Bers, Donald MHudmon, AndyHudmon, Andy and Hudmon, Andy
The Journal of biological chemistry, vol. 287, (no. 24), pp. 19856-69, 2012/Jun/8. | Journal Article
 
Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition induces neurotoxicity via dysregulation of glutamate/calcium signaling and hyperexcitability.
Ashpole, Nicole MAshpole, Nicole MSong, WeihuaSong, WeihuaBrustovetsky, TatianaBrustovetsky, TatianaEngleman, Eric AEngleman, Eric ABrustovetsky, NickolayBrustovetsky, NickolayCummins, Theodore RCummins, Theodore RHudmon, Andy and Hudmon, Andy
The Journal of biological chemistry, vol. 287, (no. 11), pp. 8495-506, 2012/Mar/9. | Journal Article
 
Delayed calcium dysregulation in neurons requires both the NMDA receptor and the reverse Na+/Ca2 + exchanger
Brittain, Matthew KBrittain, Matthew KBrustovetsky, TatianaBrustovetsky, TatianaSheets, Patrick LSheets, Patrick LBrittain, Joel MBrittain, Joel MKhanna, RajeshKhanna, RajeshCummins, Theodore RCummins, Theodore RBrustovetsky, Nickolay and Brustovetsky, Nickolay
Neurobiology of Disease, vol. 46, (no. 1), pp. 109-117, 2012. | Journal Article
 
Identification of the benzyloxyphenyl pharmacophore: a structural unit that promotes sodium channel slow inactivation.
King, AmberYang, Xiao-FangWang, YuyingDustrude, Erik TBarbosa, CindyDue, Michael RPiekarz, Andrew DWilson, Sarah MWhite, Fletcher ASalomé, ChristopheCummins, Theodore RKhanna, Rajesh and Kohn, Harold
ACS chemical neuroscience, vol. 3, (no. 12), pp. 1037-49, 2012/Dec/19. | Journal Article
 
Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons.
Brittain, Matthew KBrittain, Matthew KBrustovetsky, TatianaBrustovetsky, TatianaBrittain, Joel MBrittain, Joel MKhanna, RajeshKhanna, RajeshCummins, Theodore RCummins, Theodore RBrustovetsky, Nickolay and Brustovetsky, Nickolay
Neuropharmacology, vol. 63, (no. 6), pp. 974-82, 2012/Nov. | Journal Article
 
Sensitivity of cloned muscle, heart and neuronal voltage-gated sodium channels to block by polyamines
Fu, Li-YingCummins, Theodore R and Moczydlowski, Edward G
Channels, vol. 6, (no. 1), pp. 49, 1/1/2012. | Journal Article
 
The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity.
Song, WeihuaSong, WeihuaXiao, YuchengXiao, YuchengChen, HanyingChen, HanyingAshpole, Nicole MAshpole, Nicole MPiekarz, Andrew DPiekarz, Andrew DMa, PeilinMa, PeilinHudmon, AndyHudmon, AndyCummins, Theodore RCummins, Theodore RShou, Weinian and Shou, Weinian
The Journal of physiology, vol. 590, (no. Pt 20), pp. 5123-39, 2012/Oct/15. | Journal Article
2011
Common molecular determinants of tarantula huwentoxin-IV inhibition of Na+ channel voltage sensors in domains II and IV.
Xiao, YuchengJackson, James OLiang, Songping and Cummins, Theodore R
The Journal of biological chemistry, vol. 286, (no. 31), pp. 27301-10, 2011/Aug/5. | Journal Article
 
Extended passaging increases the efficiency of neural differentiation from induced pluripotent stem cells.
Koehler, Karl RTropel, PhilippeTheile, Jonathan WKondo, TakakoCummins, Theodore RViville, Stéphane and Hashino, Eri
BMC neuroscience, vol. 12, pp. 82, 2011. | Journal Article
 
Further insights into the antinociceptive potential of a peptide disrupting the N-type calcium channel-CRMP-2 signaling complex.
Wilson, Sarah MWilson, Sarah MWilson, Sarah MBrittain, Joel MBrittain, Joel MBrittain, Joel MPiekarz, Andrew DPiekarz, Andrew DPiekarz, Andrew DBallard, Carrie JBallard, Carrie JBallard, Carrie JRipsch, Matthew SRipsch, Matthew SRipsch, Matthew SCummins, Theodore RCummins, Theodore RCummins, Theodore RHurley, Joyce HHurley, Joyce HHurley, Joyce HKhanna, MayKhanna, MayKhanna, MayHammes, Nathan MHammes, Nathan MHammes, Nathan MSamuels, Brian CSamuels, Brian CSamuels, Brian CWhite, Fletcher AWhite, Fletcher AWhite, Fletcher AKhanna, RajeshKhanna, Rajesh and Khanna, Rajesh
Channels (Austin, Tex.), vol. 5, (no. 5), pp. 449-56, 2011 Sep-Oct. | Journal Article
 
Inhibition of Navβ4 peptide-mediated resurgent sodium currents in Nav1.7 channels by carbamazepine, riluzole, and anandamide.
Theile, Jonathan W and Cummins, Theodore R
Molecular pharmacology, vol. 80, (no. 4), pp. 724-34, 2011/Oct. | Journal Article
 
Isolation and Characterization of CvIV4: A Pain Inducing α- Scorpion Toxin
Rowe, Ashlee HXiao, YuchengScales, JosephLinse, Klaus DRowe, Matthew PCummins, Theodore R and Zakon, Harold H
PloS one, vol. 6, (no. 8), pp. e23520, 2011-00-00. | Journal Article
 
KB-R7943, an inhibitor of the reverse Na+/Ca2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex I
Brustovetsky, TatianaBrustovetsky, TatianaBrittain, Matthew KBrittain, Matthew KSheets, Patrick LSheets, Patrick LCummins, Theodore RCummins, Theodore RPinelis, VsevolodPinelis, VsevolodBrustovetsky, Nickolay and Brustovetsky, Nickolay
British Journal of Pharmacology, vol. 162, (no. 1), pp. 255-270, 2011. | Journal Article
 
Lidocaine reduces the transition to slow inactivation in Na(v)1.7 voltage-gated sodium channels.
Sheets, Patrick LSheets, Patrick LJarecki, Brian WJarecki, Brian WCummins, Theodore R and Cummins, Theodore R
British journal of pharmacology, vol. 164, (no. 2b), pp. 719-30, 2011/Sep. | Journal Article
 
Nav1.7 mutations associated with paroxysmal extreme pain disorder, but not erythromelalgia, enhance Navbeta4 peptide-mediated resurgent sodium currents.
Theile, Jonathan WJarecki, Brian WPiekarz, Andrew D and Cummins, Theodore R
The Journal of physiology, vol. 589, (no. Pt 3), pp. 597-608, 2011/Feb/1. | Journal Article
 
Recent developments regarding voltage-gated sodium channel blockers for the treatment of inherited and acquired neuropathic pain syndromes.
Theile, Jonathan W and Cummins, Theodore R
Frontiers in pharmacology, vol. 2, pp. 54, 2011. | Journal Article
2010
Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents.
Jarecki, Brian WPiekarz, Andrew DJackson, James O and Cummins, Theodore R
The Journal of clinical investigation, vol. 120, (no. 1), pp. 369-78, 2010/Jan. | Journal Article
 
In Silico Docking and Electrophysiological Characterization of Lacosamide Binding Sites on Collapsin Response Mediator Protein-2 Identifies a Pocket Important in Modulating Sodium Channel Slow Inactivation
Wang, YuyingWang, YuyingBrittain, Joel MBrittain, Joel MJarecki, Brian WJarecki, Brian WPark, Ki DPark, Ki DukWilson, Sarah MWilson, Sarah MWang, BoWang, BoHale, RachelHale, RachelMeroueh, Samy OMeroueh, SamyCummins, Theodore RCummins, Theodore RKhanna, Rajesh and Khanna, Rajesh
Journal of Biological Chemistry, vol. 285, (no. 33), pp. 25296-25307, 2010. | Journal Article
 
Sodium channels in normal and pathological pain.
Dib Hajj, SulaymanCummins, Theodore RBlack, Joel A and Waxman, Stephen G
Annual review of neuroscience, vol. 33, pp. 325-47, 2010. | Journal Article
 
Sodium Channels in Normal and Pathological Pain
Dib Hajj, SulaymanCummins, Theodore RBlack, Joel A and Waxman, Stephen G
Annual Review of Neuroscience, vol. 33, pp. 325-347, 2010. | Journal Article
 
Sodium Channels in Normal and Pathological Pain
Dib Hajj, SulaymanCummins, Theodore RBlack, Joel A and Waxman, Stephen G
Annual Review of Neuroscience, vol. 33, 2010. | Journal Article
 
The Tarantula Toxins ProTx-II and Huwentoxin-IV Differentially Interact with Human Nav1.7 Voltage Sensors to Inhibit Channel Activation and Inactivation
Xiao, YuchengBlumenthal, Kenneth MJackson, James OLiang, Songping and Cummins, Theodore R
Molecular Pharmacology, vol. 78, (no. 6), pp. 1124-1134, 2010. | Journal Article