151 Publications (Page 2 of 7)
2014
Tetrodotoxin-resistant sodium channels in sensory neurons generate slow resurgent currents that are enhanced by inflammatory mediators.Tan, Zhi Yong⋅Piekarz, Andrew D⋅Priest, Birgit T⋅Knopp, Kelly L⋅Krajewski, Jeffrey L⋅McDermott, Jeff S⋅Nisenbaum, Eric S and Cummins, Theodore RThe Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 34, (no. 21), pp. 7190-7197, May 21, 2014.
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2013
Structural Basis for the Modulation of the Neuronal Voltage-Gated Sodium Channel NaV1.6 by CalmodulinReddy Chichili, Vishnu Priyanka⋅Xiao, Yucheng⋅Seetharaman, J⋅Cummins, Theodore R and Sivaraman, JScientific reports, vol. 3, (no. 1), pp. 2435, 2013-00-00.
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Voltage-gated sodium channel in grasshopper mice defends against bark scorpion toxin.Rowe, Ashlee H⋅Xiao, Yucheng⋅Rowe, Matthew P⋅Cummins, Theodore R and Zakon, Harold HScience (New York, N.Y.), vol. 342, (no. 6157), pp. 441-446, October 25, 2013.
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2012
Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites.Ashpole, Nicole M⋅Ashpole, Nicole M.⋅Ashpole, Nicole M⋅Herren, Anthony W.⋅Herren, Anthony W⋅Herren, Anthony W⋅Ginsburg, Kenneth S.⋅Ginsburg, Kenneth S⋅Ginsburg, Kenneth S⋅Brogan, Joseph D⋅Brogan, Joseph D⋅Brogan, Joseph D.⋅Johnson, Derrick E.⋅Johnson, Derrick E⋅Johnson, Derrick E⋅Cummins, Theodore R⋅Cummins, Theodore R⋅Cummins, Theodore R.⋅Bers, Donald M⋅Bers, Donald M.⋅Bers, Donald M⋅Hudmon, Andy⋅Hudmon, Andy and Hudmon, AndyThe Journal of biological chemistry, vol. 287, (no. 24), pp. 19856-69, 2012/Jun/8.
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Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition induces neurotoxicity via dysregulation of glutamate/calcium signaling and hyperexcitability.Ashpole, Nicole M⋅Ashpole, Nicole M⋅Song, Weihua⋅Song, Weihua⋅Brustovetsky, Tatiana⋅Brustovetsky, Tatiana⋅Engleman, Eric A⋅Engleman, Eric A⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay⋅Cummins, Theodore R⋅Cummins, Theodore R⋅Hudmon, Andy and Hudmon, AndyThe Journal of biological chemistry, vol. 287, (no. 11), pp. 8495-506, 2012/Mar/9.
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Delayed calcium dysregulation in neurons requires both the NMDA receptor and the reverse Na+/Ca2 + exchangerBrittain, Matthew K⋅Brittain, Matthew K⋅Brustovetsky, Tatiana⋅Brustovetsky, Tatiana⋅Sheets, Patrick L⋅Sheets, Patrick L⋅Brittain, Joel M⋅Brittain, Joel M⋅Khanna, Rajesh⋅Khanna, Rajesh⋅Cummins, Theodore R⋅Cummins, Theodore R⋅Brustovetsky, Nickolay and Brustovetsky, NickolayNeurobiology of Disease, vol. 46, (no. 1), pp. 109-117, 2012.
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Identification of the benzyloxyphenyl pharmacophore: a structural unit that promotes sodium channel slow inactivation.King, Amber⋅Yang, Xiao-Fang⋅Wang, Yuying⋅Dustrude, Erik T⋅Barbosa, Cindy⋅Due, Michael R⋅Piekarz, Andrew D⋅Wilson, Sarah M⋅White, Fletcher A⋅Salomé, Christophe⋅Cummins, Theodore R⋅Khanna, Rajesh and Kohn, HaroldACS chemical neuroscience, vol. 3, (no. 12), pp. 1037-49, 2012/Dec/19.
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Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons.Brittain, Matthew K⋅Brittain, Matthew K⋅Brustovetsky, Tatiana⋅Brustovetsky, Tatiana⋅Brittain, Joel M⋅Brittain, Joel M⋅Khanna, Rajesh⋅Khanna, Rajesh⋅Cummins, Theodore R⋅Cummins, Theodore R⋅Brustovetsky, Nickolay and Brustovetsky, NickolayNeuropharmacology, vol. 63, (no. 6), pp. 974-82, 2012/Nov.
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Sensitivity of cloned muscle, heart and neuronal voltage-gated sodium channels to block by polyaminesFu, Li-Ying⋅Cummins, Theodore R and Moczydlowski, Edward GChannels, vol. 6, (no. 1), pp. 49, 1/1/2012.
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The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity.Song, Weihua⋅Song, Weihua⋅Xiao, Yucheng⋅Xiao, Yucheng⋅Chen, Hanying⋅Chen, Hanying⋅Ashpole, Nicole M⋅Ashpole, Nicole M⋅Piekarz, Andrew D⋅Piekarz, Andrew D⋅Ma, Peilin⋅Ma, Peilin⋅Hudmon, Andy⋅Hudmon, Andy⋅Cummins, Theodore R⋅Cummins, Theodore R⋅Shou, Weinian and Shou, WeinianThe Journal of physiology, vol. 590, (no. Pt 20), pp. 5123-39, 2012/Oct/15.
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2011
Common molecular determinants of tarantula huwentoxin-IV inhibition of Na+ channel voltage sensors in domains II and IV.Xiao, Yucheng⋅Jackson, James O⋅Liang, Songping and Cummins, Theodore RThe Journal of biological chemistry, vol. 286, (no. 31), pp. 27301-10, 2011/Aug/5.
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Extended passaging increases the efficiency of neural differentiation from induced pluripotent stem cells.Koehler, Karl R⋅Tropel, Philippe⋅Theile, Jonathan W⋅Kondo, Takako⋅Cummins, Theodore R⋅Viville, Stéphane and Hashino, EriBMC neuroscience, vol. 12, pp. 82, 2011.
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Further insights into the antinociceptive potential of a peptide disrupting the N-type calcium channel-CRMP-2 signaling complex.Wilson, Sarah M⋅Wilson, Sarah M⋅Wilson, Sarah M⋅Brittain, Joel M⋅Brittain, Joel M⋅Brittain, Joel M⋅Piekarz, Andrew D⋅Piekarz, Andrew D⋅Piekarz, Andrew D⋅Ballard, Carrie J⋅Ballard, Carrie J⋅Ballard, Carrie J⋅Ripsch, Matthew S⋅Ripsch, Matthew S⋅Ripsch, Matthew S⋅Cummins, Theodore R⋅Cummins, Theodore R⋅Cummins, Theodore R⋅Hurley, Joyce H⋅Hurley, Joyce H⋅Hurley, Joyce H⋅Khanna, May⋅Khanna, May⋅Khanna, May⋅Hammes, Nathan M⋅Hammes, Nathan M⋅Hammes, Nathan M⋅Samuels, Brian C⋅Samuels, Brian C⋅Samuels, Brian C⋅White, Fletcher A⋅White, Fletcher A⋅White, Fletcher A⋅Khanna, Rajesh⋅Khanna, Rajesh and Khanna, RajeshChannels (Austin, Tex.), vol. 5, (no. 5), pp. 449-56, 2011 Sep-Oct.
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Inhibition of Navβ4 peptide-mediated resurgent sodium currents in Nav1.7 channels by carbamazepine, riluzole, and anandamide.Theile, Jonathan W and Cummins, Theodore RMolecular pharmacology, vol. 80, (no. 4), pp. 724-34, 2011/Oct.
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Isolation and Characterization of CvIV4: A Pain Inducing α- Scorpion ToxinRowe, Ashlee H⋅Xiao, Yucheng⋅Scales, Joseph⋅Linse, Klaus D⋅Rowe, Matthew P⋅Cummins, Theodore R and Zakon, Harold HPloS one, vol. 6, (no. 8), pp. e23520, 2011-00-00.
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KB-R7943, an inhibitor of the reverse Na+/Ca2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex IBrustovetsky, Tatiana⋅Brustovetsky, Tatiana⋅Brittain, Matthew K⋅Brittain, Matthew K⋅Sheets, Patrick L⋅Sheets, Patrick L⋅Cummins, Theodore R⋅Cummins, Theodore R⋅Pinelis, Vsevolod⋅Pinelis, Vsevolod⋅Brustovetsky, Nickolay and Brustovetsky, NickolayBritish Journal of Pharmacology, vol. 162, (no. 1), pp. 255-270, 2011.
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Lidocaine reduces the transition to slow inactivation in Na(v)1.7 voltage-gated sodium channels.Sheets, Patrick L⋅Sheets, Patrick L⋅Jarecki, Brian W⋅Jarecki, Brian W⋅Cummins, Theodore R and Cummins, Theodore RBritish journal of pharmacology, vol. 164, (no. 2b), pp. 719-30, 2011/Sep.
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Nav1.7 mutations associated with paroxysmal extreme pain disorder, but not erythromelalgia, enhance Navbeta4 peptide-mediated resurgent sodium currents.Theile, Jonathan W⋅Jarecki, Brian W⋅Piekarz, Andrew D and Cummins, Theodore RThe Journal of physiology, vol. 589, (no. Pt 3), pp. 597-608, 2011/Feb/1.
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Recent developments regarding voltage-gated sodium channel blockers for the treatment of inherited and acquired neuropathic pain syndromes.Theile, Jonathan W and Cummins, Theodore RFrontiers in pharmacology, vol. 2, pp. 54, 2011.
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2010
Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents.Jarecki, Brian W⋅Piekarz, Andrew D⋅Jackson, James O and Cummins, Theodore RThe Journal of clinical investigation, vol. 120, (no. 1), pp. 369-78, 2010/Jan.
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In Silico Docking and Electrophysiological Characterization of Lacosamide Binding Sites on Collapsin Response Mediator Protein-2 Identifies a Pocket Important in Modulating Sodium Channel Slow InactivationWang, Yuying⋅Wang, Yuying⋅Brittain, Joel M⋅Brittain, Joel M⋅Jarecki, Brian W⋅Jarecki, Brian W⋅Park, Ki D⋅Park, Ki Duk⋅Wilson, Sarah M⋅Wilson, Sarah M⋅Wang, Bo⋅Wang, Bo⋅Hale, Rachel⋅Hale, Rachel⋅Meroueh, Samy O⋅Meroueh, Samy⋅Cummins, Theodore R⋅Cummins, Theodore R⋅Khanna, Rajesh and Khanna, RajeshJournal of Biological Chemistry, vol. 285, (no. 33), pp. 25296-25307, 2010.
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The Tarantula Toxins ProTx-II and Huwentoxin-IV Differentially Interact with Human Nav1.7 Voltage Sensors to Inhibit Channel Activation and InactivationXiao, Yucheng⋅Blumenthal, Kenneth M⋅Jackson, James O⋅Liang, Songping and Cummins, Theodore RMolecular Pharmacology, vol. 78, (no. 6), pp. 1124-1134, 2010.
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