151 Publications (Page 1 of 7)
2020
Differential Inhibition of Human Nav1.2 Resurgent and Persistent Sodium Currents by Cannabidiol and GS967
Mason, Emily R and Cummins, Theodore R
International journal of molecular sciences, vol. 21, (no. 7), pp. 2454, 2020-Apr-01. | Journal Article
 
Distinct functional alterations in SCN8A epilepsy mutant channels
Pan, Yanling and Cummins, Theodore R
The Journal of Physiology, vol. 598, (no. 2), pp. 401, 15 January 2020. | Journal Article
 
Energy Metabolism and Mitochondrial Superoxide Anion Production in Pre-symptomatic Striatal Neurons Derived from Human-Induced Pluripotent Stem Cells Expressing Mutant Huntingtin
Hamilton, James⋅Hamilton, James⋅Brustovetsky, Tatiana⋅Brustovetsky, Tatiana⋅Sridhar, Akshayalakshmi⋅Sridhar, Akshayalakshmi⋅Pan, Yanling⋅Pan, Yanling⋅Cummins, Theodore R⋅Cummins, Theodore R⋅Meyer, Jason S⋅Meyer, Jason S⋅Brustovetsky, Nickolay and Brustovetsky, Nickolay
Molecular neurobiology, vol. 57, (no. 2), pp. 684, 2020-Feb. | Journal Article
 
S -Palmitoylation of the sodium channel Nav1.6 regulates its activity and neuronal excitability
Pan, Yanling⋅Xiao, Yucheng⋅Pei, Zifan and Cummins, Theodore R
The Journal of biological chemistry, vol. 295, (no. 18), pp. 6164, 2020-May-01. | Journal Article
2019
Astrocytes Regulate the Development and Maturation of Retinal Ganglion Cells Derived from Human Pluripotent Stem Cells
VanderWall, Kirstin B⋅VanderWall, Kirstin B⋅VanderWall, Kirstin B⋅Vij, Ridhima⋅Vij, Ridhima⋅Vij, Ridhima⋅Ohlemacher, Sarah K⋅Ohlemacher, Sarah K⋅Ohlemacher, Sarah K⋅Sridhar, Akshayalakshmi⋅Sridhar, Akshayalakshmi⋅Sridhar, Akshayalakshmi⋅Fligor, Clarisse M⋅Fligor, Clarisse M⋅Fligor, Clarisse M⋅Feder, Elyse M⋅Feder, Elyse M⋅Feder, Elyse M⋅Edler, Michael C⋅Edler, Michael C⋅Edler, Michael C⋅Baucum, Anthony J⋅Baucum, Anthony J⋅Baucum, Anthony J⋅Cummins, Theodore R⋅Cummins, Theodore R⋅Cummins, Theodore R⋅Meyer, Jason S⋅Meyer, Jason S and Meyer, Jason S
Stem Cell Reports, vol. 12, (no. 2), pp. 212, 2019-02-12. | Journal Article
 
Extracellular signal-regulated kinases mediate the enhancing effects of inflammatory mediators on resurgent currents in dorsal root ganglion neurons
Wu, Bin⋅Wu, Bin⋅McDermott, Jeff S⋅McDermott, Jeff S⋅Krajewski, Jeffrey L⋅Krajewski, Jeffrey L⋅Knopp, Kelly L⋅Knopp, Kelly L⋅Nisenbaum, Eric S⋅Nisenbaum, Eric S⋅Cummins, Theodore R⋅Cummins, Theodore R⋅Tan, Zhi-Yong and Tan, Zhi Yong
Molecular Pain, vol. 15, pp. 1744806919837104, 20190300. | Journal Article
 
Hedgehog Pathway Activation Alters Ciliary Signaling in Primary Hypothalamic Cultures
Bansal, Ruchi⋅Bansal, Ruchi⋅Engle, Staci E⋅Engle, Staci E⋅Engle, Staci E⋅Antonellis, Patrick J⋅Antonellis, Patrick J⋅Antonellis, Patrick J⋅Whitehouse, Logan S⋅Whitehouse, Logan S⋅Whitehouse, Logan S⋅Baucum, Anthony J⋅Baucum, 2nd, Anthony J⋅Baucum, 2nd, Anthony J⋅Cummins, Theodore R⋅Cummins, Theodore R⋅Reiter, Jeremy F⋅Reiter, Jeremy F⋅Cummins, Theodore R⋅Berbari, Nicolas F⋅Berbari, Nicolas F⋅Reiter, Jeremy F and Berbari, Nicolas F
Frontiers in cellular neuroscience, vol. 13, pp. 266, 2019-00-00. | Journal Article
 
Increased Resurgent Sodium Currents in Nav1.8 Contribute to Nociceptive Sensory Neuron Hyperexcitability Associated with Peripheral Neuropathies
Xiao, Yucheng⋅Barbosa, Cindy⋅Pei, Zifan⋅Xie, Wenrui⋅Strong, Judith A⋅Zhang, Jun-Ming and Cummins, Theodore R
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 39, (no. 8), pp. 1550, 2019-02-20. | Journal Article
 
Resurgent and Gating Pore Currents Induced by De Novo SCN2A Epilepsy Mutations
Mason, Emily R⋅Wu, Fenfen⋅Patel, Reesha R⋅Xiao, Yucheng⋅Cannon, Stephen C and Cummins, Theodore R
eNeuro, vol. 6, (no. 5), pp. ENEURO.0141-19.2019, 2019 Sep/Oct. | Journal Article
 
The Diurnal Rhythm of Insulin Receptor Substrate-1 (IRS-1) and Kir4.1 in Diabetes: Implications for a Clock Gene Bmal1
Luo, Qianyi⋅Luo, Qianyi⋅Xiao, Yucheng⋅Xiao, Yucheng⋅Alex, Alpha⋅Alex, Alpha⋅Cummins, Theodore R⋅Cummins, Theodore R⋅Bhatwadekar, Ashay D and Bhatwadekar, Ashay D
Investigative ophthalmology & visual science, vol. 60, (no. 6), pp. 1936, 2019-05-01. | Journal Article
2018
Advanced glycation end (AGE) product modification of laminin downregulates Kir4.1 in retinal Müller cells
Thompson, Kayla⋅Thompson, Kayla⋅Chen, Jonathan⋅Chen, Jonathan⋅Luo, Qianyi⋅Luo, Qianyi⋅Xiao, Yucheng⋅Xiao, Yucheng⋅Cummins, Theodore R⋅Cummins, Theodore R⋅Bhatwadekar, Ashay D and Bhatwadekar, Ashay D
PloS one, vol. 13, (no. 2), pp. e0193280, 2018-00-00. | Journal Article
2017
FHF2 isoforms differentially regulate Nav1.6-mediated resurgent sodium currents in dorsal root ganglion neurons
Barbosa, Cindy⋅Barbosa, Cindy⋅Xiao, Yucheng⋅Xiao, Yucheng⋅Johnson, Andrew⋅Johnson, Andrew⋅Xie, Wenrui⋅Xie, Wenrui⋅Strong, Judith⋅Strong, Judith⋅Zhang, Jun-Ming⋅Zhang, Jun-Ming⋅Cummins, Theodore and Cummins, Theodore
Pflügers Archiv - European Journal of Physiology, vol. 469, (no. 2), pp. 212, 20170200. | Journal Article
2016
Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol
Patel, Reesha R⋅Barbosa, Cindy⋅Brustovetsky, Tatiana⋅Brustovetsky, Nickolay and Cummins, Theodore R
Brain : a journal of neurology, vol. 139, (no. Pt 8), pp. 2181, 2016-08-00. | Journal Article
 
Cardiac sodium channel palmitoylation regulates channel availability and myocyte excitability with implications for arrhythmia generation
Pei, Zifan⋅Pei, Zifan⋅Pei, Zifan⋅Xiao, Yucheng⋅Xiao, Yucheng⋅Xiao, Yucheng⋅Meng, Jingwei⋅Meng, Jingwei⋅Meng, Jingwei⋅Hudmon, Andy⋅Hudmon, Andy⋅Hudmon, Andy⋅Cummins, Theodore R⋅Cummins, Theodore R and Cummins, Theodore R
Nature communications, vol. 7, (no. 1), pp. 12035, 2016-06-23. | Journal Article
 
Stepwise Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells Enables Analysis of Glaucomatous Neurodegeneration
Ohlemacher, Sarah K⋅Ohlemacher, Sarah K⋅Sridhar, Akshayalakshmi⋅Sridhar, Akshayalakshmi⋅Xiao, Yucheng⋅Xiao, Yucheng⋅Hochstetler, Alexandra E⋅Hochstetler, Alexandra E⋅Sarfarazi, Mansoor⋅Sarfarazi, Mansoor⋅Cummins, Theodore R⋅Cummins, Theodore R⋅Meyer, Jason S and Meyer, Jason S
STEM CELLS, vol. 34, (no. 6), pp. 1562, June 2016. | Journal Article
 
t‐boc synthesis of huwentoxin‐i through native chemical ligation incorporating a trifluoromethanesulfonic acid cleavage strategy
Thapa, Parashar⋅Thapa, Parashar⋅Cabalteja, Chino C⋅Cabalteja, Chino C⋅Philips, Edwin E⋅Philips, Edwin E⋅Espiritu, Michael J⋅Espiritu, Michael J⋅Peigneur, Steve⋅Peigneur, Steve⋅Mille, Bea G⋅Mille, Bea G⋅Tytgat, Jan⋅Tytgat, Jan⋅Cummins, Theodore R⋅Cummins, Theodore R⋅Bingham, Jon‐Paul and Bingham, Jon Paul
Peptide Science, vol. 106, (no. 5), pp. 745, September 2016. | Journal Article
 
Upregulation of the sodium channel NaVβ4 subunit and its contributions to mechanical hypersensitivity and neuronal hyperexcitability in a rat model of radicular pain induced by local DRG inflammation
Xie, Wenrui⋅Tan, Zhi-Yong⋅Barbosa, Cindy⋅Strong, Judith A⋅Cummins, Theodore R and Zhang, Jun-Ming
Pain, vol. 157, (no. 4), pp. 891, 2016-04-01. | Journal Article
2015
Chimeric derivatives of functionalized amino acids and [alpha]-aminoamides: Compounds with anticonvulsant activity in seizure models and inhibitory actions on central, peripheral, and cardiac isoforms of voltage-gated sodium channels
Torregrosa, Robert⋅Torregrosa, Robert⋅Yang, Xiao-Fang⋅Yang, Xiao-Fang⋅Dustrude, Erik⋅Dustrude, Erik T⋅Cummins, Theodore⋅Cummins, Theodore R⋅Khanna, Rajesh⋅Khanna, Rajesh⋅Kohn, Harold and Kohn, Harold
Bioorganic & Medicinal Chemistry, vol. 23, (no. 13), pp. 3655, 20150701. | Journal Article
 
Human Nav1.6 Channels Generate Larger Resurgent Currents than Human Nav1.1 Channels, but the Navβ4 Peptide Does Not Protect Either Isoform from Use-Dependent Reduction
Patel, Reesha R⋅Barbosa, Cindy⋅Xiao, Yucheng and Cummins, Theodore R
PloS one, vol. 10, (no. 7), pp. e0133485, 2015-00-00. | Journal Article
 
Navβ4 regulates fast resurgent sodium currents and excitability in sensory neurons.
Barbosa, Cindy⋅Tan, Zhi-Yong⋅Wang, Ruizhong⋅Xie, Wenrui⋅Strong, Judith A⋅Patel, Reesha R⋅Vasko, Michael R⋅Zhang, Jun-Ming and Cummins, Theodore R
Molecular pain, vol. 11, pp. 60, 2015. | Journal Article
2014
Furanocoumarins Are a Novel Class of Modulators for the Transient Receptor Potential Vanilloid Type 1 (TRPV1) Channel
Chen, Xingjuan⋅Chen, Xingjuan⋅Sun, Weiyang⋅Sun, Weiyang⋅Gianaris, Nicholas G⋅Gianaris, Nicholas G⋅Riley, Ashley M⋅Riley, Ashley M⋅Cummins, Theodore R⋅Cummins, Theodore R⋅Fehrenbacher, Jill C⋅Fehrenbacher, Jill C⋅Obukhov, Alexander G and Obukhov, Alexander G
The Journal of biological chemistry, vol. 289, (no. 14), pp. 9610, 2014-Apr-04. | Journal Article
 
Gating-pore currents demonstrate selective and specific modulation of individual sodium channel voltage-sensors by biological toxins.
Xiao, Yucheng⋅Blumenthal, Kenneth M and Cummins, Theodore R
Molecular pharmacology, vol. 86, (no. 2), pp. 159-67, 2014/Aug. | Journal Article
 
Modulation of cardiac sodium channel by palmitoylation and its association with cardiac disease mutations
Pei, Zifan⋅Pei, Zifan⋅Hudmon, Andy⋅Hudmon, Andy⋅Cummins, Theodore and Cummins, Theodore
Circulation, vol. 130, (no. 22), 20141125. | Journal Article
 
Protein kinase C enhances human sodium channel hNav1.7 resurgent currents via a serine residue in the domain III–IV linker
Tan, Zhi-Yong⋅Priest, Birgit T⋅Krajewski, Jeffrey L⋅Knopp, Kelly L⋅Nisenbaum, Eric S and Cummins, Theodore R
FEBS Letters, vol. 588, (no. 21), pp. 3969, 2014-11-03. | Journal Article
 
Substituted N-(biphenyl-4'-yl)methyl (R)-2-acetamido-3-methoxypropionamides: potent anticonvulsants that affect frequency (use) dependence and slow inactivation of sodium channels.
Lee, Hyosung⋅Park, Ki D⋅Torregrosa, Robert⋅Yang, Xiao-Fang⋅Dustrude, Erik T⋅Wang, Yuying⋅Wilson, Sarah M⋅Barbosa, Cindy⋅Xiao, Yucheng⋅Cummins, Theodore R⋅Khanna, Rajesh and Kohn, Harold
Journal of medicinal chemistry, vol. 57, (no. 14), pp. 6165-82, 2014/Jul/24. | Journal Article