151 Publications (Page 1 of 7)
Differential Inhibition of Human Nav1.2 Resurgent and Persistent Sodium Currents by Cannabidiol and GS967
Mason, Emily R and Cummins, Theodore R
International journal of molecular sciences, vol. 21, (no. 7), pp. 2454, 2020-Apr-01. | Journal Article
Distinct functional alterations in SCN8A epilepsy mutant channels
Pan, Yanling and Cummins, Theodore R
The Journal of Physiology, vol. 598, (no. 2), pp. 401, 15 January 2020. | Journal Article
Energy Metabolism and Mitochondrial Superoxide Anion Production in Pre-symptomatic Striatal Neurons Derived from Human-Induced Pluripotent Stem Cells Expressing Mutant Huntingtin
Hamilton, JamesHamilton, JamesBrustovetsky, TatianaBrustovetsky, TatianaSridhar, AkshayalakshmiSridhar, AkshayalakshmiPan, YanlingPan, YanlingCummins, Theodore RCummins, Theodore RMeyer, Jason SMeyer, Jason SBrustovetsky, Nickolay and Brustovetsky, Nickolay
Molecular neurobiology, vol. 57, (no. 2), pp. 684, 2020-Feb. | Journal Article
S -Palmitoylation of the sodium channel Nav1.6 regulates its activity and neuronal excitability
Pan, YanlingXiao, YuchengPei, Zifan and Cummins, Theodore R
The Journal of biological chemistry, vol. 295, (no. 18), pp. 6164, 2020-May-01. | Journal Article
Astrocytes Regulate the Development and Maturation of Retinal Ganglion Cells Derived from Human Pluripotent Stem Cells
VanderWall, Kirstin BVanderWall, Kirstin BVanderWall, Kirstin BVij, RidhimaVij, RidhimaVij, RidhimaOhlemacher, Sarah KOhlemacher, Sarah KOhlemacher, Sarah KSridhar, AkshayalakshmiSridhar, AkshayalakshmiSridhar, AkshayalakshmiFligor, Clarisse MFligor, Clarisse MFligor, Clarisse MFeder, Elyse MFeder, Elyse MFeder, Elyse MEdler, Michael CEdler, Michael CEdler, Michael CBaucum, Anthony JBaucum, Anthony JBaucum, Anthony JCummins, Theodore RCummins, Theodore RCummins, Theodore RMeyer, Jason SMeyer, Jason S and Meyer, Jason S
Stem Cell Reports, vol. 12, (no. 2), pp. 212, 2019-02-12. | Journal Article
Extracellular signal-regulated kinases mediate the enhancing effects of inflammatory mediators on resurgent currents in dorsal root ganglion neurons
Wu, BinWu, BinMcDermott, Jeff SMcDermott, Jeff SKrajewski, Jeffrey LKrajewski, Jeffrey LKnopp, Kelly LKnopp, Kelly LNisenbaum, Eric SNisenbaum, Eric SCummins, Theodore RCummins, Theodore RTan, Zhi-Yong and Tan, Zhi Yong
Molecular Pain, vol. 15, pp. 1744806919837104, 20190300. | Journal Article
Hedgehog Pathway Activation Alters Ciliary Signaling in Primary Hypothalamic Cultures
Bansal, RuchiBansal, RuchiEngle, Staci EEngle, Staci EEngle, Staci EAntonellis, Patrick JAntonellis, Patrick JAntonellis, Patrick JWhitehouse, Logan SWhitehouse, Logan SWhitehouse, Logan SBaucum, Anthony JBaucum, 2nd, Anthony JBaucum, 2nd, Anthony JCummins, Theodore RCummins, Theodore RReiter, Jeremy FCummins, Theodore RReiter, Jeremy FBerbari, Nicolas FBerbari, Nicolas FReiter, Jeremy F and Berbari, Nicolas F
Frontiers in cellular neuroscience, vol. 13, pp. 266, 2019-00-00. | Journal Article
Increased Resurgent Sodium Currents in Nav1.8 Contribute to Nociceptive Sensory Neuron Hyperexcitability Associated with Peripheral Neuropathies
Xiao, YuchengBarbosa, CindyPei, ZifanXie, WenruiStrong, Judith AZhang, Jun-Ming and Cummins, Theodore R
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 39, (no. 8), pp. 1550, 2019-02-20. | Journal Article
Resurgent and Gating Pore Currents Induced by De Novo SCN2A Epilepsy Mutations
Mason, Emily RWu, FenfenPatel, Reesha RXiao, YuchengCannon, Stephen C and Cummins, Theodore R
eNeuro, vol. 6, (no. 5), pp. ENEURO.0141-19.2019, 2019 Sep/Oct. | Journal Article
The Diurnal Rhythm of Insulin Receptor Substrate-1 (IRS-1) and Kir4.1 in Diabetes: Implications for a Clock Gene Bmal1
Luo, QianyiLuo, QianyiXiao, YuchengXiao, YuchengAlex, AlphaAlex, AlphaCummins, Theodore RCummins, Theodore RBhatwadekar, Ashay D and Bhatwadekar, Ashay D
Investigative ophthalmology & visual science, vol. 60, (no. 6), pp. 1936, 2019-05-01. | Journal Article
Advanced glycation end (AGE) product modification of laminin downregulates Kir4.1 in retinal Müller cells
Thompson, KaylaThompson, KaylaChen, JonathanChen, JonathanLuo, QianyiLuo, QianyiXiao, YuchengXiao, YuchengCummins, Theodore RCummins, Theodore RBhatwadekar, Ashay D and Bhatwadekar, Ashay D
PloS one, vol. 13, (no. 2), pp. e0193280, 2018-00-00. | Journal Article
FHF2 isoforms differentially regulate Nav1.6-mediated resurgent sodium currents in dorsal root ganglion neurons
Barbosa, CindyBarbosa, CindyXiao, YuchengXiao, YuchengJohnson, AndrewJohnson, AndrewXie, WenruiXie, WenruiStrong, JudithStrong, JudithZhang, Jun-MingZhang, Jun-MingCummins, Theodore and Cummins, Theodore
Pflügers Archiv - European Journal of Physiology, vol. 469, (no. 2), pp. 212, 20170200. | Journal Article
Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol
Patel, Reesha RBarbosa, CindyBrustovetsky, TatianaBrustovetsky, Nickolay and Cummins, Theodore R
Brain : a journal of neurology, vol. 139, (no. Pt 8), pp. 2181, 2016-08-00. | Journal Article
Cardiac sodium channel palmitoylation regulates channel availability and myocyte excitability with implications for arrhythmia generation
Pei, ZifanPei, ZifanPei, ZifanXiao, YuchengXiao, YuchengXiao, YuchengMeng, JingweiMeng, JingweiMeng, JingweiHudmon, AndyHudmon, AndyHudmon, AndyCummins, Theodore RCummins, Theodore R and Cummins, Theodore R
Nature communications, vol. 7, (no. 1), pp. 12035, 2016-06-23. | Journal Article
Stepwise Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells Enables Analysis of Glaucomatous Neurodegeneration
Ohlemacher, Sarah KOhlemacher, Sarah KSridhar, AkshayalakshmiSridhar, AkshayalakshmiXiao, YuchengXiao, YuchengHochstetler, Alexandra EHochstetler, Alexandra ESarfarazi, MansoorSarfarazi, MansoorCummins, Theodore RCummins, Theodore RMeyer, Jason S and Meyer, Jason S
STEM CELLS, vol. 34, (no. 6), pp. 1562, June 2016. | Journal Article
t‐boc synthesis of huwentoxin‐i through native chemical ligation incorporating a trifluoromethanesulfonic acid cleavage strategy
Thapa, ParasharThapa, ParasharCabalteja, Chino CCabalteja, Chino CPhilips, Edwin EPhilips, Edwin EEspiritu, Michael JEspiritu, Michael JPeigneur, StevePeigneur, SteveMille, Bea GMille, Bea GTytgat, JanTytgat, JanCummins, Theodore RCummins, Theodore RBingham, Jon‐Paul and Bingham, Jon Paul
Peptide Science, vol. 106, (no. 5), pp. 745, September 2016. | Journal Article
Upregulation of the sodium channel NaVβ4 subunit and its contributions to mechanical hypersensitivity and neuronal hyperexcitability in a rat model of radicular pain induced by local DRG inflammation
Xie, WenruiTan, Zhi-YongBarbosa, CindyStrong, Judith ACummins, Theodore R and Zhang, Jun-Ming
Pain, vol. 157, (no. 4), pp. 891, 2016-04-01. | Journal Article
Chimeric derivatives of functionalized amino acids and [alpha]-aminoamides: Compounds with anticonvulsant activity in seizure models and inhibitory actions on central, peripheral, and cardiac isoforms of voltage-gated sodium channels
Torregrosa, RobertTorregrosa, RobertYang, Xiao-FangYang, Xiao-FangDustrude, ErikDustrude, Erik TCummins, Theodore RCummins, TheodoreKhanna, RajeshKhanna, RajeshKohn, Harold and Kohn, Harold
Bioorganic & Medicinal Chemistry, vol. 23, (no. 13), pp. 3655, 20150701. | Journal Article
Human Nav1.6 Channels Generate Larger Resurgent Currents than Human Nav1.1 Channels, but the Navβ4 Peptide Does Not Protect Either Isoform from Use-Dependent Reduction
Patel, Reesha RBarbosa, CindyXiao, Yucheng and Cummins, Theodore R
PloS one, vol. 10, (no. 7), pp. e0133485, 2015-00-00. | Journal Article
Navβ4 regulates fast resurgent sodium currents and excitability in sensory neurons.
Barbosa, CindyTan, Zhi-YongWang, RuizhongXie, WenruiStrong, Judith APatel, Reesha RVasko, Michael RZhang, Jun-Ming and Cummins, Theodore R
Molecular pain, vol. 11, pp. 60, 2015. | Journal Article
Furanocoumarins Are a Novel Class of Modulators for the Transient Receptor Potential Vanilloid Type 1 (TRPV1) Channel
Chen, XingjuanChen, XingjuanSun, WeiyangSun, WeiyangGianaris, Nicholas GGianaris, Nicholas GRiley, Ashley MRiley, Ashley MCummins, Theodore RCummins, Theodore RFehrenbacher, Jill CFehrenbacher, Jill CObukhov, Alexander G and Obukhov, Alexander G
The Journal of biological chemistry, vol. 289, (no. 14), pp. 9610, 2014-Apr-04. | Journal Article
Gating-pore currents demonstrate selective and specific modulation of individual sodium channel voltage-sensors by biological toxins.
Xiao, YuchengBlumenthal, Kenneth M and Cummins, Theodore R
Molecular pharmacology, vol. 86, (no. 2), pp. 159-67, 2014/Aug. | Journal Article
Modulation of cardiac sodium channel by palmitoylation and its association with cardiac disease mutations
Pei, ZifanPei, ZifanPei, ZifanHudmon, AndyHudmon, AndyHudmon, AndyCummins, TheodoreCummins, Theodore and Cummins, Theodore
Circulation, vol. 130, (no. 22), 20141125. | Journal Article
Protein kinase C enhances human sodium channel hNav1.7 resurgent currents via a serine residue in the domain III–IV linker
Tan, Zhi-YongPriest, Birgit TKrajewski, Jeffrey LKnopp, Kelly LNisenbaum, Eric S and Cummins, Theodore R
FEBS Letters, vol. 588, (no. 21), pp. 3969, 2014-11-03. | Journal Article
Substituted N-(biphenyl-4'-yl)methyl (R)-2-acetamido-3-methoxypropionamides: potent anticonvulsants that affect frequency (use) dependence and slow inactivation of sodium channels.
Lee, HyosungPark, Ki DTorregrosa, RobertYang, Xiao-FangDustrude, Erik TWang, YuyingWilson, Sarah MBarbosa, CindyXiao, YuchengCummins, Theodore RKhanna, Rajesh and Kohn, Harold
Journal of medicinal chemistry, vol. 57, (no. 14), pp. 6165-82, 2014/Jul/24. | Journal Article