His current studies involve the physiochemical coupling between the folding and trafficking of integral membrane proteins in the cell. His laboratory utilizes an interdisciplinary array of biophysical, analytical, and cellular techniques to gain mechanistic insights into the key reactions that modulate the cellular proteostasis of integral membrane proteins and ultimately give rise to the molecular basis of disease. His group is also interested in adapting these tools and perspectives to address emerging issues in precision medicine.
Research:
- Cotranslational Misfolding and Integral Membrane Proteostasis
- Deep Mutational Scanning of Disease-Linked Integral Membrane Proteins
- Impact of Pathogenic Mutations on Membrane Protein Folding and Function
- Impact of Cotranslational Folding on Programmed Ribosomal Frameshifting
Subject areas:
- Quantitative Biology and Biophysics
- Life
Research Interests:
- folding, processing, and quality control of integral membrane proteins in the cell; high–throughput characterization of rare mutations in disease-linked integral membrane proteins
