105 Publications (Page 4 of 5)
2010
Protein phosphatase 2A acts as a mitogen-activated protein kinase kinase kinase 3 (MEKK3) phosphatase to inhibit lysophosphatidic acid-induced IkappaB kinase beta/nuclear factor-kappaB activation.
Sun, Wenjing⋅Wang, Hao⋅Zhao, Xiumei⋅Yu, Yang⋅Fan, Yihui⋅Wang, Xishan⋅Lu, Xiongbin⋅Zhang, Guiyin⋅Fu, Songbin and Yang, Jianhua
The Journal of biological chemistry, vol. 285, (no. 28), pp. 21341-8, 2010/Jul/9. | Journal Article
 
Synthesis and characterization of thermally responsive Pluronic F127-chitosan nanocapsules for controlled release and intracellular delivery of small molecules.
Zhang, Wujie⋅Zhang, W.⋅Gilstrap, K.⋅Gilstrap, Kyle⋅Wu, Laying⋅Wu, L.⋅Remant Bahadur, K.C.⋅K C, Remant B⋅Moss, Melissa A⋅Moss, M.A.⋅Wang, Q.⋅Wang, Qian⋅Lu, X.⋅Lu, Xiongbin⋅He, X. and He, Xiaoming
ACS nano, vol. 4, (no. 11), pp. 6747-59, 2010/Nov/23. | Journal Article
 
The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair
Nguyen, Thuy-Ai⋅Slattery, Scott D⋅Moon, Sung-Hwan⋅Darlington, Yolanda F⋅Lu, Xiongbin and Donehower, Lawrence A
DNA Repair, vol. 9, (no. 7), pp. 813-823, 2010. | Journal Article
 
USP11 negatively regulates TNFalpha-induced NF-kappaB activation by targeting on IkappaBalpha.
Sun, Wenjing⋅Sun, Wenjing⋅Tan, Xiaojie⋅Tan, Xiaojie⋅Shi, Yi⋅Shi, Yi⋅Xu, Gufeng⋅Xu, Gufeng⋅Mao, Renfang⋅Mao, Renfang⋅Gu, Xue⋅Gu, Xue⋅Fan, Yihui⋅Fan, Yihui⋅Yu, Yang⋅Yu, Yang⋅Burlingame, Susan⋅Burlingame, Susan⋅Zhang, Hong⋅Zhang, Hong⋅Rednam, Surya P⋅Rednam, Surya P⋅Lu, Xiongbin⋅Lu, Xiongbin⋅Zhang, Ting⋅Zhang, Ting⋅Fu, Songbin⋅Fu, Songbin⋅Cao, Guangwen⋅Cao, Guangwen⋅Qin, Jun⋅Qin, Jun⋅Yang, Jianhua and Yang, Jianhua
Cellular signalling, vol. 22, (no. 3), pp. 386-94, 2010/Mar. | Journal Article
 
Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair.
Moon, Sung-Hwan⋅Moon, Sung-Hwan⋅Lin, Lin⋅Lin, Lin⋅Zhang, Xinna⋅Zhang, Xinna⋅Nguyen, Thuy-Ai⋅Nguyen, Thuy-Ai⋅Darlington, Yolanda⋅Darlington, Yolanda⋅Waldman, Alan S⋅Waldman, Alan S⋅Lu, Xiongbin⋅Lu, Xiongbin⋅Donehower, Lawrence A and Donehower, Lawrence A
The Journal of biological chemistry, vol. 285, (no. 17), pp. 12935-12947, April 23, 2010. | Journal Article
 
Wild-type p53-induced Phosphatase 1 Dephosphorylates Histone Variant gamma -H2AX and Suppresses DNA Double Strand Break Repair
Moon, Sung-Hwan⋅Lin, Lin⋅Zhang, Xinna⋅Nguyen, Thuy-Ai⋅Darlington, Yolanda⋅Waldman, Alan S⋅Lu, Xiongbin and Donehower, Lawrence A
Journal of Biological Chemistry, vol. 285, (no. 17), pp. 12935-12947, 2010. | Journal Article
2009
Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response.
Zhang, Xinna⋅Zhang, Xinna⋅Lin, Lin⋅Lin, Lin⋅Guo, Huarong⋅Guo, Huarong⋅Yang, Jianhua⋅Yang, Jianhua⋅Jones, Stephen N⋅Jones, Stephen⋅Jochemsen, Aart⋅Jochemsen, Aart⋅Lu, Xiongbin and Lu, Xiongbin
Cancer research, vol. 69, (no. 20), pp. 7960-8, 2009/Oct/15. | Journal Article
 
PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation.
Sun, Wenjing⋅Yu, Yang⋅Dotti, Gianpietro⋅Shen, Tao⋅Tan, Xiaojie⋅Savoldo, Barbara⋅Pass, Amy K⋅Chu, Meijin⋅Zhang, Dekai⋅Lu, Xiongbin⋅Fu, Songbin⋅Lin, Xia and Yang, Jianhua
Cellular signalling, vol. 21, (no. 1), pp. 95-102, 2009/Jan. | Journal Article
2008
Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D.
Castellino, Robert C⋅De Bortoli, Massimiliano⋅Lu, Xiongbin⋅Moon, Sung-Hwan⋅Nguyen, Thuy-Ai⋅Shepard, Mark A⋅Rao, Pulivarthi H⋅Donehower, Lawrence A and Kim, John Y
Journal of neuro-oncology, vol. 86, (no. 3), pp. 245-56, 2008/Feb. | Journal Article
 
The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways
Lu, Xiongbin⋅Nguyen, Thuy-Ai⋅Moon, Sung-Hwan⋅Darlington, Yolanda⋅Sommer, Matthias and Donehower, Lawrence A
Cancer and Metastasis Reviews, vol. 27, (no. 2), pp. 123-135, 2008. | Journal Article
 
The Wip1 phosphatase and Mdm2: cracking the "Wip" on p53 stability.
Lu, Xiongbin⋅Lu, Xiongbin⋅Nguyen, Thuy-Ai⋅Nguyen, Thuy-Ai⋅Zhang, X⋅Zhang, Xinna⋅Donehower, Lawrence A and Donehower, Lawrence A
Cell cycle (Georgetown, Tex.), vol. 7, (no. 2), pp. 164-8, 2008/Jan/15. | Journal Article
2007
Aging-associated truncated form of p53 interacts with wild-type p53 and alters p53 stability, localization, and activity
Moore, Lynette⋅Lu, Xiongbin⋅Ghebranious, Nader⋅Tyner, Stuart and Donehower, Lawrence A
Mechanisms of Ageing and Development, vol. 128, (no. 11-12), pp. 717-730, 2007. | Journal Article
 
The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.
Lu, Xiongbin⋅Ma, Ou⋅Nguyen, Thuy-Ai⋅Jones, Stephen N⋅Oren, Moshe and Donehower, Lawrence A
Cancer cell, vol. 12, (no. 4), pp. 342-54, 2007/Oct. | Journal Article
2006
Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.
Nannenga, Bonnie⋅Lu, Xiongbin⋅Dumble, Melissa⋅Van Maanen, Marc⋅Nguyen, Thuy-Ai⋅Sutton, Richard⋅Kumar, Raj R and Donehower, Lawrence A
Molecular carcinogenesis, vol. 45, (no. 8), pp. 594-604, 2006/Aug. | Journal Article
2005
53BP1 oligomerization is independent of its methylation by PRMT1.
Adams, Melissa M⋅Wang, Bin⋅Xia, Zhenfang⋅Morales, Julio C⋅Lu, Xiongbin⋅Donehower, Lawrence A⋅Bochar, Daniel A⋅Elledge, Stephen J and Carpenter, Phillip B
Cell cycle (Georgetown, Tex.), vol. 4, (no. 12), pp. 1854-61, 2005/Dec. | Journal Article
 
PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints
Lu, Xiongbin⋅Nannenga, Bonnie and Donehower, Lawrence A
Genes & Development, vol. 19, (no. 10), pp. 1162-1174, 2005. | Journal Article
 
PPMID dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints
Lu, Xiongbin⋅Nannenga, Bonnie and Donehower, Lawrence
Genes & Development, vol. 19, (no. 10), pp. 1162, 20050515. | Journal Article
 
Reversal of the ATM/ATR-mediated DNA damage response by the oncogenic phosphatase PPM1D.
Lu, Xiongbin⋅Nguyen, Thuy-Ai and Donehower, Lawrence A
Cell cycle (Georgetown, Tex.), vol. 4, (no. 8), pp. 1060-4, 2005/Aug. | Journal Article
2004
Homeostatic regulation of base excision repair by a p53-induced phosphatase: linking stress response pathways with DNA repair proteins.
Lu, Xiongbin⋅Nguyen, Thuy-Ai⋅Appella, Ettore and Donehower, Lawrence A
Cell cycle (Georgetown, Tex.), vol. 3, (no. 11), pp. 1363-6, 2004/Nov. | Journal Article
 
The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair.
Lu, Xiongbin⋅Bocangel, Dora⋅Nannenga, Bonnie⋅Yamaguchi, Hiroshi⋅Appella, Ettore and Donehower, Lawrence A
Molecular cell, vol. 15, (no. 4), pp. 621-34, 2004/Aug/27. | Journal Article
2003
Activities of wildtype and mutant p53 in suppression of homologous recombination as measured by a retroviral vector system
Lu, Xiongbin⋅Lozano, Guillermina and Donehower, Lawrence A
Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, vol. 522, (no. 1-2), pp. 69-83, 2003. | Journal Article
 
Generation and characterization of p53 mutant mice.
Dumble, Melissa L⋅Donehower, Lawrence A and Lu, Xiongbin
Methods in molecular biology (Clifton, N.J.), vol. 234, pp. 29-49, 2003. | Journal Article
2002
Asymmetric requirement for cholesterol in receptor-bearing but not envelope-bearing membranes for fusion mediated by ecotropic murine leukemia virus.
Lu, Xiongbin⋅Xiong, Ying and Silver, Jonathan
Journal of virology, vol. 76, (no. 13), pp. 6701-9, 2002/Jul. | Journal Article
 
p53 mutant mice that display early ageing-associated phenotypes
Tyner, SD⋅Venkatachalam, Sundaresan⋅Choi, J.⋅Jones, Stephen N⋅Ghebranious, N.⋅Igelman, H.⋅Lu, Xiongbin⋅Soron, G.⋅Cooper, B.⋅Flagg Brayton, Cory⋅Park, SH⋅Thompson, Timothy C⋅Karsenty, Gerard⋅Bradley, Allan and Donehower, Lawrence A
Nature, vol. 412, (no. 6867), pp. 45-53, 2002. | Journal Article
 
p53 mutant mice that display early ageing-associated phenotypes.
Tyner, Stuart D⋅Venkatachalam, Sundaresan⋅Choi, Jene⋅Jones, Stephen N⋅Ghebranious, Nader⋅Igelmann, Herbert⋅Lu, Xiongbin⋅Soron, Gabrielle⋅Cooper, Benjamin⋅Flagg Brayton, Cory⋅Park, Sang H⋅Thompson, Timothy C⋅Karsenty, Gerard⋅Bradley, Allan and Donehower, Lawrence A
Nature, vol. 415, (no. 6867), pp. 45-53, 2002/Jan/3. | Journal Article