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Expertise

Dr. Tao Lu has an extensive background in signaling transduction, molecular and cellular biology, biochemistry, genetics, and pharmacology with specific expertise in NF-kB signaling, post-translational modification, cancer epigenetics, and drug discovery.

My research centers on the multi-functional transcription factor nuclear factor kB (NFkB). Since many cancers are characterized by constitutive activation of NFkB, my recent work has focused on investigating the causes of constitutive activation of NFkB in cancer and to develop and use novel forward genetic screening methods to identify regulators of NFkB. I expect this research to lead to new strategies for the prevention and treatment of cancer.

My research focuses on addressing how NF-κB is regulated and how this regulation contributes to tumorigenesis

Research:

  • Epigenetic Regulation of NF-kB in cancer and inflammatory disease
  • Using Validation-based insertional mutagenesis (VBIM) technique to discover novel genes

Research: Cellular and Molecular Metabolism

Past Affiliations

Member, Center for Diabetes and Metabolic Diseases, Centers and Institutes, Indiana University School of Medicine

Assistant Professor, Department of Pharmacology and Toxicology, Indiana University-Purdue University Indianapolis, School of Medicine (past)

Research Associate, Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic (past)

Assistant Professor, Department of Biochemistry and Molecular Biology, Indiana University-Purdue University Indianapolis, School of Medicine (past)

Communities
Biochemistry, Molecular Biology, Oncology, Pharmacology, Cellular Biochemistry, Molecular Biochemistry, Toxicology
Degrees
PhD, University of Toledo, Molecular and Cellular Biology, 2001
MS, Shandong University, Biochemistry and Molecular Biology, 1994
BS, Nanjing University, Biochemistry, 1991