32 Publications (Page 1 of 2)
2019
Combined Heterozygous Loss of Tet2 and Dnmt3a Along with Expression of Flt3ITD/WT results in Acute Myeloid Leukemia Which Responds to a Combination of FLT3 Inhibitor, APE1 Inhibitor and Decitabine
Ramdas, BaskarRamdas, BaskarRamdas, BaskarPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyMali, Raghuveer SinghMali, Raghuveer SinghMali, Raghuveer SinghCai, ZhigangCai, ZhigangCai, ZhigangPandey, RuchiPandey, RuchiPandey, RuchiKapur, ReubenKapur, Reuben and Kapur, Reuben
Blood, vol. 134, (no. Supplement_1), pp. 3754, 2019-11-13. | Journal Article
 
Cooperativity between Flt3/Syk and Proteasome Inhibitors in Flt3mutant/Wildtype AML, By Acting on the Oxphos and Wnt Endpoints of Syk and p62SQSTM1 Pathways Prohibits Protective Autophagy; While Downregulation of NRF2, NQO1, Jun, and b-Catenin Bypasses Interfering RAS or WT1 Co-Mutations
Rangaraju, SravantiRangaraju, SravantiRangaraju, SravantiRangaraju, SravantiRangaraju, SravantiMarino, SilviaMarino, SilviaMarino, SilviaMarino, SilviaMarino, SilviaRoodman, G. DavidRoodman, G. DavidRoodman, G. DavidRoodman, G. DavidRoodman, G. DavidCripe, Larry DCripe, Larry DCripe, Larry DCripe, Larry DCripe, Larry DRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddySargent, Katie JSargent, Katie JSargent, Katie JSargent, Katie JSargent, Katie JSayar, HamidSayar, HamidSayar, HamidSayar, HamidSayar, HamidKonig, HeikoKonig, HeikoKonig, HeikoKonig, HeikoKonig, HeikoKapur, ReubenKapur, ReubenKapur, ReubenKapur, ReubenKapur, ReubenBoswell, H. ScottBoswell, H. ScottBoswell, H. ScottBoswell, H. Scott and Boswell, H. Scott
Blood, vol. 134, (no. Supplement_1), pp. 5051, 2019-11-13. | Journal Article
 
Lncrna Morrbid Regulates Myeloid Cell Survival of AML Driven By a Combination of FLT3ITD and Epigenetic Mutations
Cai, ZhigangCai, ZhigangRamdas, BaskarRamdas, BaskarKotzin, JonathanKotzin, JonathanCarroll, Martin PCarroll, Martin PWertheim, GeraldWertheim, GeraldWilliams, AdamWilliams, AdamHenao-Mejia, JorgeHenao-Mejia, JorgeKapur, Reuben and Kapur, Reuben
Blood, vol. 134, (no. Supplement_1), pp. 915, 2019-11-13. | Journal Article
 
Loss of Dnmt3a Dysregulates Hematopoietic Homeostasis and Myeloid Skewing Via the PI3Kinase Pathway: PI3Kα/β Inhibition Corrects Extramedullary Hematopoiesis and Myeloid Skewing Due to Loss of Dnmt3a
Palam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyRamdas, BaskarRamdas, BaskarRamdas, BaskarPickerell, KatelynPickerell, KatelynPickerell, KatelynKapur, ReubenKapur, Reuben and Kapur, Reuben
Blood, vol. 134, (no. Supplement_1), pp. 723, 2019-11-13. | Journal Article
 
SHP2 inhibition reduces leukemogenesis in models of combined genetic and epigenetic mutations
Pandey, RuchiPandey, RuchiPandey, RuchiPandey, RuchiPandey, RuchiRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarWan, ChanglinWan, ChanglinWan, ChanglinWan, ChanglinWan, ChanglinSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeMohseni, MorvaridMohseni, MorvaridMohseni, MorvaridMohseni, MorvaridMohseni, MorvaridZhang, ChiZhang, ChiZhang, ChiZhang, ChiZhang, ChiKapur, ReubenKapur, ReubenKapur, ReubenKapur, Reuben and Kapur, Reuben
The Journal of clinical investigation, vol. 129, (no. 12), pp. 5468, 2019-Dec-02. | Journal Article
2018
Combined inhibition of Bruton’s Tyrosine Kinase (BTK) and Phosphoinositide 3-kinase (PI3K) p110δ improves monocytosis and splenomegaly in a JMML Mouse Model
Patel, RoshniPatel, RoshniRamdas, BaskarRamdas, BaskarDeng, LisaDeng, LisaJideonwo-Auman, VictoriaJideonwo-Auman, VictoriaKapur, Reuben and Kapur, Reuben
Proceedings of IMPRS, vol. 1, (no. 1), 2018-12-07. | Journal Article
 
Combined Pharmacological Inhibition of Bruton's Tyrosine Kinase (BTK) and Phosphoinositide 3-Kinase (PI3K) p110δ Rescues Monocytosis, Thrombocytopenia, and Splenomegaly in a Genetic Mouse Model for JMML
Patel, RoshniPatel, RoshniRamdas, BaskarRamdas, BaskarDeng, LisaDeng, LisaJideonwo-Auman, VictoriaJideonwo-Auman, VictoriaChan, Rebecca JChan, Rebecca JKapur, Reuben and Kapur, Reuben
Blood, vol. 132, (no. Supplement 1), pp. 2623, 2018-11-29. | Journal Article
 
Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis
Cai, ZhigangCai, ZhigangCai, ZhigangCai, ZhigangCai, ZhigangCai, ZhigangCai, ZhigangKotzin, Jonathan JKotzin, Jonathan JKotzin, Jonathan JKotzin, Jonathan JKotzin, Jonathan JKotzin, Jonathan JKotzin, Jonathan JRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarChen, SisiChen, SisiChen, SisiChen, SisiChen, SisiChen, SisiChen, SisiNelanuthala, SaiNelanuthala, SaiNelanuthala, SaiNelanuthala, SaiNelanuthala, SaiNelanuthala, SaiNelanuthala, SaiPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPandey, RuchiPandey, RuchiPandey, RuchiPandey, RuchiPandey, RuchiPandey, RuchiPandey, RuchiMali, Raghuveer SinghMali, Raghuveer SinghMali, Raghuveer SinghMali, Raghuveer SinghMali, Raghuveer SinghMali, Raghuveer SinghMali, Raghuveer SinghLiu, YanLiu, YanLiu, YanLiu, YanLiu, YanLiu, YanLiu, YanKelley, Mark RKelley, Mark RKelley, Mark RKelley, Mark RKelley, Mark RKelley, Mark RKelley, Mark RSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeMohseni, MorvaridMohseni, MorvaridMohseni, MorvaridMohseni, MorvaridMohseni, MorvaridMohseni, MorvaridMohseni, MorvaridWilliams, AdamWilliams, AdamWilliams, AdamWilliams, AdamWilliams, AdamWilliams, AdamWilliams, AdamHenao-Mejia, JorgeHenao-Mejia, JorgeHenao-Mejia, JorgeHenao-Mejia, JorgeHenao-Mejia, JorgeHenao-Mejia, JorgeHenao-Mejia, JorgeKapur, ReubenKapur, ReubenKapur, ReubenKapur, ReubenKapur, ReubenKapur, Reuben and Kapur, Reuben
Cell Stem Cell, vol. 23, (no. 6), pp. 849.e5, 2018-12-06. | Journal Article
 
Loss of epigenetic regulator TET2 and oncogenic KIT regulate myeloid cell transformation via PI3K pathway
Palam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyMali, Raghuveer SinghMali, Raghuveer SinghMali, Raghuveer SinghMali, Raghuveer SinghMali, Raghuveer SinghRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarSrivatsan, Sridhar NonavinkereSrivatsan, Sridhar NonavinkereSrivatsan, Sridhar NonavinkereSrivatsan, Sridhar NonavinkereSrivatsan, Sridhar NonavinkereVisconte, ValeriaVisconte, ValeriaVisconte, ValeriaVisconte, ValeriaVisconte, ValeriaTiu, Ramon VTiu, Ramon VTiu, Ramon VTiu, Ramon VTiu, Ramon VVanhaesebroeck, BartVanhaesebroeck, BartVanhaesebroeck, BartVanhaesebroeck, BartVanhaesebroeck, BartRoers, AxelRoers, AxelRoers, AxelRoers, AxelRoers, AxelGerbaulet, AlexanderGerbaulet, AlexanderGerbaulet, AlexanderGerbaulet, AlexanderGerbaulet, AlexanderXu, MingjiangXu, MingjiangXu, MingjiangXu, MingjiangXu, MingjiangJanga, Sarath ChandraJanga, Sarath ChandraJanga, Sarath ChandraJanga, Sarath ChandraJanga, Sarath ChandraTakemoto, Clifford MTakemoto, Clifford MTakemoto, Clifford MTakemoto, Clifford MTakemoto, Clifford MPaczesny, SophiePaczesny, SophiePaczesny, SophiePaczesny, SophiePaczesny, SophieKapur, ReubenKapur, ReubenKapur, ReubenKapur, Reuben and Kapur, Reuben
JCI insight, vol. 3, (no. 4), 2018-02-22. | Journal Article
 
Rap1 Gtpases Regulate the Retention and Engraftment of Hematopoietic Stem and Progenitor Cells
Ramdas, BaskarRamdas, BaskarGhosh, JoydeepGhosh, JoydeepMali, Raghuveer SinghMali, Raghuveer SinghAmy, ZollmanAmy, ZollmanCarlesso, NadiaCarlesso, NadiaKamocka M, MalgorzataKamocka M, MalgorzataKenneth, Dunn WKenneth, Dunn WQuilliam, LawranceQuilliam, LawranceKapur, Reuben and Kapur, Reuben
Blood, vol. 132, (no. Supplement 1), pp. 326, 2018-11-29. | Journal Article
 
Temporal and Spatially Regulated Oncogenic KIT Expression and Loss of Dnmt3a Cooperate to Drive MPN Development: Role of PI3Kinase in Dnmt3a Loss Induced Hyperproliferation in Myeloid Cells
Palam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarSrivatsan, Sridhar reddySrivatsan, Sridhar reddySrivatsan, Sridhar reddySrivatsan, Sridhar reddyJanga, Sarath ChandraJanga, Sarath ChandraJanga, Sarath ChandraJanga, Sarath ChandraRoers, AxelRoers, AxelRoers, AxelRoers, AxelGerbaulet, AlexanderGerbaulet, AlexanderGerbaulet, AlexanderGerbaulet, AlexanderKapur, ReubenKapur, ReubenKapur, Reuben and Kapur, Reuben
Blood, vol. 132, (no. Supplement 1), pp. 3055, 2018-11-29. | Journal Article
2016
S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance
Ghosh, JoydeepGhosh, JoydeepKobayashi, MichihiroKobayashi, MichihiroRamdas, BaskarRamdas, BaskarChatterjee, AnindyaChatterjee, AnindyaMa, PeilinMa, PeilinMali, Raghuveer SinghMali, Raghuveer SinghCarlesso, NadiaCarlesso, NadiaLiu, YanLiu, YanPlas, David RPlas, David RChan, Rebecca JChan, Rebecca JKapur, Reuben and Kapur, Reuben
The Journal of clinical investigation, vol. 126, (no. 7), pp. 2625, 2016-07-01. | Journal Article
2015
Novel Functional Roles for Ten-Eleven-Translocation 2 (Tet2) in Normal and Leukemic Growth of Mast Cells
Mali, RaghuveerMali, RaghuveerMali, RaghuveerMartin, Holly ReneMartin, Holly ReneMartin, Holly ReneRamdas, BaskarRamdas, BaskarRamdas, BaskarPalam, LakshmiPalam, LakshmiPalam, LakshmiVisconte, ValeriaVisconte, ValeriaVisconte, ValeriaRamon, TiuRamon, TiuRamon, TiuHanenberg, HelmutHanenberg, HelmutHanenberg, HelmutXu, MingjiangXu, MingjiangXu, MingjiangKapur, ReubenKapur, Reuben and Kapur, Reuben
Blood, vol. 126, (no. 23), pp. 775, 2015-12-03. | Journal Article
 
S6K1 Regulates Self-Renewal of Leukemia Initiating Cells and Normal Hematopoietic Stem Cells
Ghosh, JoydeepGhosh, JoydeepChatterjee, AnindyaChatterjee, AnindyaRamdas, BaskarRamdas, BaskarKobayashi, MichihiroKobayashi, MichihiroMa, PeilinMa, PeilinLiu, YanLiu, YanPlas, DavidPlas, DavidKapur, Reuben and Kapur, Reuben
Blood, vol. 126, (no. 23), pp. 442, 2015-12-03. | Journal Article
2014
Modulation in the expression of p70S6 kinase impairs the engraftment and self-renewal of hematopoietic stem cells
Ghosh, JoydeepGhosh, JoydeepRamdas, BaskarRamdas, BaskarChatterjee, AnindyaChatterjee, AnindyaMa, PeilinMa, PeilinKobayashi, MichihiroKobayashi, MichihiroMali, RaghuveerMali, RaghuveerLiu, YanLiu, YanPlas, DavidPlas, DavidKapur, Reuben and Kapur, Reuben
Experimental Hematology, vol. 42, (no. 8), pp. S35, 2014. | Journal Article
 
Modulation in the Expression of p70S6 Kinase Impairs the Engraftment and Self-Renewal of Hematopoietic Stem Cells
Ghosh, JoydeepGhosh, JoydeepRamdas, BaskarRamdas, BaskarChatterjee, AnindyaChatterjee, AnindyaMa, PeilinMa, PeilinKobayashi, MichihiroKobayashi, MichihiroMali, RaghuveerMali, RaghuveerLiu, YanLiu, YanPlas, David RPlas, David RKapur, Reuben and Kapur, Reuben
Blood, vol. 124, (no. 21), pp. 252, 2014-12-06. | Journal Article
 
Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis
Chatterjee, AnindyaChatterjee, AnindyaChatterjee, AnindyaGhosh, JoydeepGhosh, JoydeepGhosh, JoydeepRamdas, BaskarRamdas, BaskarRamdas, BaskarMali, Raghuveer SinghMali, Raghuveer SinghMali, Raghuveer SinghMartin, HollyMartin, HollyMartin, HollyKobayashi, MichihiroKobayashi, MichihiroKobayashi, MichihiroVemula, SasidharVemula, SasidharVemula, SasidharCanela, Victor HCanela, Victor HCanela, Victor HWaskow, Emily RWaskow, Emily RWaskow, Emily RVisconte, ValeriaVisconte, ValeriaVisconte, ValeriaTiu, Ramon VTiu, Ramon VTiu, Ramon VSmith, Catherine CSmith, Catherine CSmith, Catherine CShah, NeilShah, NeilShah, NeilBunting, Kevin DBunting, Kevin DBunting, Kevin DBoswell, H ScottBoswell, H. ScottBoswell, H. ScottLiu, YanLiu, YanLiu, YanChan, Rebecca JChan, Rebecca JChan, Rebecca JKapur, ReubenKapur, Reuben and Kapur, Reuben
Cell Reports, vol. 9, (no. 4), pp. 1348, 2014-11-20. | Journal Article
2013
Pak and Rac GTPases promote oncogenic KIT–induced neoplasms
Martin, HollyMartin, HollyMali, Raghuveer SMali, Raghuveer SinghMa, PeilinMa, PeilinChatterjee, AnindyaChatterjee, AnindyaRamdas, BaskarRamdas, BaskarSims, EmilySims, EmilyMunugalavadla, VeerendraMunugalavadla, VeerendraGhosh, JoydeepGhosh, JoydeepMattingly, Ray RMattingly, Ray RVisconte, ValeriaVisconte, ValeriaTiu, Ramon VTiu, Ramon VVlaar, Cornelis PVlaar, Cornelis PDharmawardhane, SuranganieDharmawardhane, SuranganieKapur, Reuben and Kapur, Reuben
The Journal of clinical investigation, vol. 123, (no. 10), pp. 4463, 2013-Oct. | Journal Article
2012
p85β regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis
Krishnan, SubhaKrishnan, SubhaMali, Raghuveer SinghMali, Raghuveer SinghRamdas, BaskarRamdas, BaskarSims, EmilySims, EmilyMa, PeilinMa, PeilinGhosh, JoydeepGhosh, JoydeepMunugalavadla, VeerendraMunugalavadla, VeerendraHanneman, PhilipHanneman, PhilipBeane, Joal DBeane, Joal DKapur, Reuben and Kapur, Reuben
Blood, vol. 119, (no. 17), pp. 3961, 2012-Apr-26. | Journal Article
 
Role of intracellular tyrosines in activating KIT-induced myeloproliferative disease
Ma, PeilinMa, PeilinMali, Raghuveer SinghMali, Raghuveer SinghMartin, HollyMartin, HollyRamdas, BaskarRamdas, BaskarSims, EmilySims, EmilyKapur, Reuben and Kapur, Reuben
Leukemia, vol. 26, (no. 7), pp. 1506, 2012-Jul. | Journal Article
 
Role of p21 Activated Kinase and Specific Guanine Exchange Factors of Rac Gtpases in Oncogenic KIT Induced Systemic Mastocytosis and Acute Myeloid Leukemia
Martin, HollyMartin, HollyMa, PeilinMa, PeilinChatterjee, AnindyaChatterjee, AnindyaRamdas, BaskarRamdas, BaskarSims, EmilySims, EmilyVlaar, CornelisVlaar, CornelisDharmawardhane, SuraganieDharmawardhane, SuraganieKapur, Reuben and Kapur, Reuben
Blood, vol. 120, (no. 21), pp. 810, 2012-11-16. | Journal Article
 
Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT
Mali, Raghuveer SMali, Raghuveer SinghMali, Raghuveer SinghMali, Raghuveer SinghMa, PeilinMa, PeilinMa, PeilinMa, PeilinZeng, Li-FanZeng, Li-FanZeng, Li-FanZeng, Li-FanMartin, HollyMartin, HollyMartin, HollyMartin, HollyRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarHe, YantaoHe, YantaoHe, YantaoHe, YantaoSims, EmilySims, EmilySims, EmilySims, EmilyNabinger, SarahNabinger, SarahNabinger, SarahNabinger, SarahGhosh, JoydeepGhosh, JoydeepGhosh, JoydeepGhosh, JoydeepSharma, NamitSharma, NamitSharma, NamitSharma, NamitMunugalavadla, VeerendraMunugalavadla, VeerendraMunugalavadla, VeerendraMunugalavadla, VeerendraChatterjee, AnindyaChatterjee, AnindyaChatterjee, AnindyaChatterjee, AnindyaLi, ShuoLi, ShuoLi, ShuoLi, ShuoSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeCraig, Andrew WCraig, Andrew WCraig, Andrew WCraig, Andrew WBunting, Kevin DBunting, Kevin DBunting, Kevin DBunting, Kevin DFeng, Gen-ShengFeng, Gen-ShengFeng, Gen-ShengFeng, Gen-ShengChan, Rebecca JChan, Rebecca JChan, Rebecca JChan, Rebecca JZhang, Zhong-YinZhang, Zhong-YinZhang, Zhong-YinZhang, Z. FKapur, ReubenKapur, ReubenKapur, Reuben and Kapur, Reuben
Blood, vol. 120, (no. 13), pp. 2678, 2012-Sep-27. | Journal Article
 
The Protein Tyrosine Phosphatase, Shp2, Positively Contributes to FLT3-ITD-Induced Malignant Disease in Vivo and Co-Localizes with Nuclear Phospho-STAT5 in FLT3-ITD-Expressing Leukemic Cells
Nabinger, Sarah CNabinger, Sarah CNabinger, Sarah CLi, Xing JunLi, Xing JunLi, Xing JunRamdas, BaskarRamdas, BaskarRamdas, BaskarHe, YantaoHe, YantaoHe, YantaoZhang, XianZhang, XianZhang, XianRichine, BrianaRichine, BrianaRichine, BrianaBowling, JoshuaBowling, JoshuaBowling, JoshuaFukuda, SeijiFukuda, SeijiFukuda, SeijiGoenka, ShreevratGoenka, ShreevratGoenka, ShreevratLiu, ZiyueLiu, ZiyueLiu, ZiyueFeng, Gen-ShengFeng, Gen-ShengFeng, Gen-ShengYu, MenggangYu, MenggangYu, MenggangSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeBoswell, H. ScottBoswell, H. ScottBoswell, H. ScottZhang, Zhong-YinZhang, Zhong-YinZhang, Zhong-YinKapur, ReubenKapur, ReubenKapur, ReubenChan, Rebecca JChan, Rebecca J and Chan, Rebecca J
Blood, vol. 120, (no. 21), pp. 2420, 2012-11-16. | Journal Article
 
Unraveling a Novel Mechanism of Stat5 Regulation by FAK and Rac1 in Flt3ITD Induced Leukemogenesis
Chatterjee, AnindyaChatterjee, AnindyaChatterjee, AnindyaGhosh, JoydeepGhosh, JoydeepGhosh, JoydeepRamdas, BaskarRamdas, BaskarRamdas, BaskarVemula, SasidharVemula, SasidharVemula, SasidharMartin, HollyMartin, HollyMartin, HollyMali, RaghuveerMali, RaghuveerMali, RaghuveerNabinger, Sarah CNabinger, Sarah CNabinger, Sarah CGoodwin, Charles BGoodwin, Charles BGoodwin, Charles BBoswell, H. ScottBoswell, H. ScottBoswell, H. ScottChan, Rebecca JChan, Rebecca JChan, Rebecca JKapur, ReubenKapur, Reuben and Kapur, Reuben
Blood, vol. 120, (no. 21), pp. 858, 2012-11-16. | Journal Article
2011
Balanced Interactions between Lyn, the p85α Regulatory Subunit of Class IA Phosphatidylinositol-3-Kinase, and SHIP Are Essential for Mast Cell Growth and Maturation
Ma, PeilinMa, PeilinVemula, SasidharVemula, SasidharMunugalavadla, VeerendraMunugalavadla, VeerendraChen, JinbiaoChen, JinbiaoSims, EmilySims, EmilyBorneo, JovencioBorneo, JovencioKondo, TakakoKondo, TakakoRamdas, BaskarRamdas, BaskarMali, RaghuveerMali, Raghuveer SLi, ShuoLi, ShuoHashino, EriHashino, EriTakemoto, CliffordTakemoto, CliffordKapur, Reuben and Kapur, Reuben
Molecular and Cellular Biology, vol. 31, (no. 19), pp. 4062, 20111001. | Journal Article