41 Publications (Page 1 of 2)
2024
A Translational Regulatory Mechanism Mediated by Hypusinated Eukaryotic Initiation Factor 5A Facilitates β-Cell Identity and Function. Diabetes
. | Journal Article
2023
Deoxyhypusine synthase (DHPS) mutations alter the post-translational modification of eukaryotic translation factor 5A (eIF5A) resulting in impaired human and mouse neural homeostasis. Human Genetics and Genomics Advances
. | Journal Article
 
Deoxyhypusine synthase is required for the translational regulation of pancreatic beta cell maturation
 
Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes
Mastracci, Teresa L⋅Mastracci, Teresa L⋅Apte, Minoti⋅Apte, Minoti⋅Amundadottir, Laufey T⋅Amundadottir, Laufey T⋅Alvarsson, Alexandra⋅Alvarsson, Alexandra⋅Artandi, Steven⋅Artandi, Steven⋅Bellin, Melena D⋅Bellin, Melena D⋅Bernal-Mizrachi, Ernesto⋅Bernal-Mizrachi, Ernesto⋅Caicedo, Alejandro⋅Caicedo, Alejandro⋅Campbell-Thompson, Martha⋅Campbell-Thompson, Martha⋅Cruz-Monserrate, Zobeida⋅Cruz-Monserrate, Zobeida⋅El Ouaamari, Abdelfattah⋅El Ouaamari, Abdelfattah⋅Gaulton, Kyle J⋅Gaulton, Kyle J⋅Geisz, Andrea⋅Geisz, Andrea⋅Goodarzi, Mark O⋅Goodarzi, Mark O⋅Hara, Manami⋅Hara, Manami⋅Hull-Meichle, Rebecca L⋅Hull-Meichle, Rebecca L⋅Kleger, Alexander⋅Kleger, Alexander⋅Klein, Alison P⋅Klein, Alison P⋅Kopp, Janel L⋅Kopp, Janel L⋅Kulkarni, Rohit N⋅Kulkarni, Rohit N⋅Muzumdar, Mandar D⋅Muzumdar, Mandar D⋅Naren, Anjaparavanda P⋅Naren, Anjaparavanda P⋅Oakes, Scott A⋅Oakes, Scott A⋅Olesen, Søren S⋅Olesen, Søren S⋅Phelps, Edward A⋅Phelps, Edward A⋅Powers, Alvin C⋅Powers, Alvin C⋅Stabler, Cherie L⋅Stabler, Cherie L⋅Tirkes, Temel⋅Tirkes, Temel⋅Whitcomb, David C⋅Whitcomb, David C⋅Yadav, Dhiraj⋅Yadav, Dhiraj⋅Yong, Jing⋅Yong, Jing⋅Zaghloul, Norann A⋅Zaghloul, Norann A⋅Pandol, Stephen J⋅Pandol, Stephen J⋅Sander, Maike and Sander, Maike
. | Journal Article
2022
Exocrine-Endocrine Crosstalk: The Influence of Pancreatic Cellular Communications on Organ Growth, Function and Disease
Overton, D.L. and Mastracci, T.L.
Frontiers in Endocrinology, vol. 13. | Journal Article
2021
Deoxyhypusine synthase, an essential enzyme for hypusine biosynthesis, is required for proper exocrine pancreas development
Padgett, Leah R.⋅Robertson, Morgan A.⋅Anderson-Baucum, Emily K.⋅Connors, Craig T.⋅Wu, Wenting⋅Mirmira, Raghavendra G. and Mastracci, Teresa L.
The FASEB Journal, vol. 35. | Journal Article
 
Deoxyhypusine synthase promotes a pro-inflammatory macrophage phenotype
Anderson-Baucum, Emily⋅Anderson-Baucum, E.⋅Piñeros, A.R.⋅Piñeros, Annie R⋅Kulkarni, A.⋅Kulkarni, Abhishek⋅Webb-Robertson, Bobbie-Jo⋅Webb-Robertson, B.-J.⋅Maier, Bernhard⋅Maier, B.⋅Anderson, R.M.⋅Anderson, Ryan M⋅Wu, W.⋅Wu, Wenting⋅Tersey, Sarah A⋅Tersey, S.A.⋅Mastracci, Teresa L⋅Mastracci, T.L.⋅Casimiro, Isabel⋅Casimiro, I.⋅Scheuner, Donalyn⋅Scheuner, D.⋅Metz, Thomas O⋅Metz, T.O.⋅Nakayasu, Ernesto S⋅Nakayasu, E.S.⋅Evans-Molina, Carmella⋅Evans-Molina, C.⋅Mirmira, R.G. and Mirmira, Raghavendra G
Cell Metabolism, vol. 33, pp. 1883-1893.e7. | Journal Article
 
Neuron Specific Ablation of eIF5A or Deoxyhypusine Synthase Leads to Impairment in Development and Cognitive Functions in Mice
Kar, R.K.⋅Hanner, A.S.⋅Starost, M.F.⋅Springer, D.⋅Mastracci, T.L.⋅Mirmira, R.G. and Park, M.H.
 
Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice
Kar, R.K.⋅Hanner, A.S.⋅Starost, M.F.⋅Springer, D.⋅Mastracci, T.L.⋅Mirmira, R.G. and Park, M.H.
Journal of Biological Chemistry, vol. 297. | Journal Article
2020
Deoxyhypusine Synthase Promotes a Pro-Inflammatory Macrophage Phenotype
Anderson-Baucum, Emily⋅Anderson-Baucum, Emily⋅Anderson-Baucum, Emily⋅Anderson-Baucum, E.⋅Pineros, Annie⋅Piñeros, A.R.⋅Pineros, Annie⋅Pineros, Annie⋅Maier, B.⋅Maier, Bernhard⋅Maier, Bernhard⋅Maier, Bernhard⋅Kulkarni, Abhishek⋅Kulkarni, A.⋅Kulkarni, Abhishek⋅Kulkarni, Abhishek⋅Anderson, R.M.⋅Anderson, Ryan M⋅Anderson, Ryan M.⋅Anderson, Ryan M⋅Wu, W.⋅Wu, Wenting⋅Wu, Wenting⋅Wu, Wenting⋅Tersey, Sarah⋅Tersey, Sarah⋅Tersey, Sarah⋅Tersey, S.A.⋅Mastracci, T.L.⋅Mastracci, Teresa⋅Mastracci, Teresa⋅Mastracci, Teresa⋅Casimiro, I.⋅Casimiro, Isabel⋅Casimiro, Isabel⋅Casimiro, Isabel⋅Scheuner, Donalyn⋅Scheuner, Donalyn⋅Scheuner, D.⋅Scheuner, Donalyn⋅Evans-Molina, C.⋅Evans-Molina, Carmella⋅Evans-Molina, Carmella⋅Evans-Molina, Carmella⋅Mirmira, Raghavendra G.⋅Mirmira, R.G.⋅Mirmira, Raghavendra G and Mirmira, Raghavendra G
 
Hypusinated eIF5A is expressed in the pancreas and spleen of individuals with type 1 and type 2 diabetes
PLOS ONE. | Journal Article
 
Targeting polyamine biosynthesis to stimulate beta cell regeneration in zebrafish
Robertson, Morgan A⋅Robertson, Morgan A.⋅Padgett, Leah R.⋅Padgett, Leah R⋅Fine, Jonathan A⋅Fine, Jonathan A.⋅Chopra, Gaurav⋅Chopra, Gaurav⋅Mastracci, Teresa L and Mastracci, Teresa L.
Islets, vol. 12, pp. 99–107. | Journal Article
2019
Abnormalities in proinsulin processing in islets from individuals with longstanding T1D
Sims, Emily K⋅Sims, E.K.⋅Syed, F.⋅Syed, Farooq⋅Nyalwidhe, J.⋅Nyalwidhe, Julius⋅Bahnson, Henry T⋅Bahnson, H.T.⋅Haataja, Leena⋅Haataja, L.⋅Speake, Cate⋅Speake, C.⋅Morris, M.A.⋅Morris, Margaret A⋅Balamurugan, Appakalai N⋅Balamurugan, A.N.⋅Mirmira, R.G.⋅Mirmira, Raghavendra G⋅Nadler, Jerry⋅Nadler, J.⋅Mastracci, T.L.⋅Mastracci, Teresa L⋅Arvan, Peter⋅Arvan, P.⋅Greenbaum, C.J.⋅Greenbaum, Carla J⋅Evans-Molina, Carmella and Evans-Molina, C.
Translational Research, vol. 213, pp. 90-99. | Journal Article
 
Abnormalities in Proinsulin Processing in Islets from Individuals with Longstanding T1D
Sims, E.K.⋅Nyalwidhe, J.⋅Syed, F.⋅Bahnson, H.T.⋅Haataja, L.⋅Speake, C.⋅Morris, M.A.⋅Mirmira, R.G.⋅Nadler, J.⋅Mastracci, T.L.⋅Arvan, P.⋅Greenbaum, C.J. and Evans-Molina, C.
 
Adiponectin receptor fragmentation in mouse models of type 1 and type 2 diabetes
Frabutt, D.⋅Stull, N.⋅Pineros, A.R.⋅Tersey, S.A.⋅Scheuner, D.⋅Mastracci, T.L. and Pugia, M.J.
 
Hypusinated eIF5A is expressed in pancreas and spleen of individuals with type 1 and type 2 diabetes
Mastracci, Teresa L⋅Colvin, Stephanie C⋅Padgett, Leah R and Mirmira, Raghavendra G
Cold Spring Harbor Laboratory
 
Hypusine biosynthesis in \upbeta cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis
Levasseur, Esther M.⋅Levasseur, Esther M⋅Levasseur, Esther M⋅Yamada, Kentaro⋅Yamada, Kentaro⋅Yamada, Kentaro⋅Piñeros, Annie R⋅Piñeros, Annie R⋅Piñeros, Annie R.⋅Wu, Wenting⋅Wu, Wenting⋅Wu, Wenting⋅Syed, Farooq⋅Syed, Farooq⋅Syed, Farooq⋅Orr, Kara S.⋅Orr, Kara S⋅Orr, Kara S⋅Anderson-Baucum, Emily⋅Anderson-Baucum, Emily⋅Anderson-Baucum, Emily⋅Mastracci, Teresa L.⋅Mastracci, Teresa L⋅Mastracci, Teresa L⋅Maier, Bernhard⋅Maier, Bernhard⋅Maier, Bernhard⋅Mosley, Amber L⋅Mosley, Amber L.⋅Mosley, Amber L⋅Liu, Yunlong⋅Liu, Yunlong⋅Liu, Yunlong⋅Bernal-Mizrachi, Ernesto⋅Bernal-Mizrachi, Ernesto⋅Bernal-Mizrachi, Ernesto⋅Alonso, Laura C⋅Alonso, Laura C.⋅Alonso, Laura C⋅Scott, Donald⋅Scott, Donald⋅Scott, Donald⋅Garcia-Ocaña, Adolfo⋅Garcia-Ocaña, Adolfo⋅Garcia-Ocaña, Adolfo⋅Tersey, Sarah A⋅Tersey, Sarah A.⋅Tersey, Sarah A⋅Mirmira, Raghavendra G.⋅Mirmira, Raghavendra G and Mirmira, Raghavendra G
Science Signaling, vol. 12, pp. eaax0715. | Journal Article
 
Proinsulin secretion is a persistent feature of type 1 diabetes
Sims, Emily K⋅Sims, Emily K⋅Sims, Emily K⋅Sims, Emily K⋅Sims, Emily K⋅Sims, E.K.⋅Bahnson, Henry T⋅Bahnson, Henry T⋅Bahnson, Henry T⋅Bahnson, Henry T⋅Bahnson, Henry T⋅Bahnson, H.T.⋅Nyalwidhe, Julius⋅Nyalwidhe, Julius⋅Nyalwidhe, Julius⋅Nyalwidhe, Julius⋅Nyalwidhe, J.⋅Nyalwidhe, Julius⋅Haataja, Leena⋅Haataja, Leena⋅Haataja, L.⋅Haataja, Leena⋅Haataja, Leena⋅Haataja, Leena⋅Davis, Asa K⋅Davis, Asa K⋅Davis, Asa K⋅Davis, Asa K⋅Davis, A.K.⋅Davis, Asa K⋅Speake, Cate⋅Speake, Cate⋅Speake, C.⋅Speake, Cate⋅Speake, Cate⋅Speake, Cate⋅Di Meglio, Linda A⋅DiMeglio, Linda A⋅DiMeglio, Linda A⋅DiMeglio, Linda A⋅DiMeglio, Linda A⋅DiMeglio, L.A.⋅Blum, Janice⋅Blum, Janice⋅Blum, Janice⋅Blum, J.⋅Blum, Janice⋅Blum, Janice⋅Morris, Margaret A⋅Morris, Margaret A⋅Morris, M.A.⋅Morris, Margaret A⋅Morris, Margaret A⋅Morris, Margaret A⋅Mirmira, R.G.⋅Mirmira, Raghavendra G⋅Mirmira, Raghavendra G⋅Mirmira, Raghavendra G⋅Mirmira, Raghavendra G⋅Mirmira, Raghavendra G⋅Nadler, Jerry⋅Nadler, Jerry⋅Nadler, J.⋅Nadler, Jerry⋅Nadler, Jerry⋅Nadler, Jerry⋅Mastracci, T.L.⋅Mastracci, Teresa L⋅Mastracci, Teresa L⋅Mastracci, Teresa L⋅Mastracci, Teresa L⋅Mastracci, Teresa L⋅Marcovina, Santica⋅Marcovina, Santica⋅Marcovina, Santica⋅Marcovina, Santica⋅Marcovina, Santica⋅Marcovina, S.⋅Qian, Wei-Jun⋅Qian, W.-J.⋅Qian, Wei-Jun⋅Qian, Wei-Jun⋅Qian, Wei-Jun⋅Qian, Wei-Jun⋅Yi, Lian⋅Yi, Lian⋅Yi, Lian⋅Yi, Lian⋅Yi, Lian⋅Yi, L.⋅Swensen, Adam C⋅Swensen, Adam C⋅Swensen, Adam C⋅Swensen, A.C.⋅Swensen, Adam C⋅Swensen, Adam C⋅Yip Schneider, Michele⋅Yip-Schneider, Michele⋅Yip-Schneider, Michele⋅Yip-Schneider, M.⋅Yip-Schneider, Michele⋅Yip-Schneider, Michele⋅Schmidt, C Max⋅Schmidt, C Max⋅Schmidt, C Max⋅Schmidt, C Max⋅Schmidt, C Max⋅Schmidt, C.M.⋅Considine, R.V.⋅Considine, Robert V⋅Considine, Robert V⋅Considine, Robert V⋅Considine, Robert V⋅Considine, Robert V⋅Arvan, Peter⋅Arvan, Peter⋅Arvan, Peter⋅Arvan, Peter⋅Arvan, Peter⋅Arvan, P.⋅Greenbaum, Carla J⋅Greenbaum, Carla J⋅Greenbaum, Carla J⋅Greenbaum, Carla J⋅Greenbaum, C.J.⋅Greenbaum, Carla J⋅Evans-Molina, C.⋅Evans-Molina, Carmella⋅Evans Molina, Carmella⋅Evans-Molina, Carmella⋅Evans-Molina, Carmella and Evans-Molina, Carmella
Diabetes Care, vol. 42, pp. 258-264. | Journal Article
 
Proinsulin secretion is a persistent feature of type 1 diabetes. Diabetes care 2019;42:258?264
Sims, Emily K⋅Sims, E.K.⋅Sims, Emily K⋅Sims, Emily K⋅Sims, Emily K⋅Sims, Emily K⋅Sims, Emily K⋅Bahnson, Henry T⋅Bahnson, Henry T⋅Bahnson, Henry T⋅Bahnson, Henry T⋅Bahnson, Henry T⋅Bahnson, H.T.⋅Bahnson, Henry T⋅Nyalwidhe, Julius⋅Nyalwidhe, Julius⋅Nyalwidhe, Julius⋅Nyalwidhe, Julius⋅Nyalwidhe, J.⋅Nyalwidhe, Julius⋅Nyalwidhe, Julius⋅Haataja, L.⋅Haataja, Leena⋅Haataja, Leena⋅Haataja, Leena⋅Haataja, Leena⋅Haataja, Leena⋅Haataja, Leena⋅Davis, Asa K⋅Davis, Asa K⋅Davis, Asa K⋅Davis, Asa K⋅Davis, Asa K⋅Davis, Asa K⋅Davis, A.K.⋅Speake, Cate⋅Speake, C.⋅Speake, Cate⋅Speake, Cate⋅Speake, Cate⋅Speake, Cate⋅Speake, Cate⋅DiMeglio, Linda A⋅DiMeglio, Linda A⋅Di Meglio, Linda A⋅DiMeglio, L.A.⋅DiMeglio, Linda A⋅DiMeglio, Linda A⋅DiMeglio, Linda A⋅Blum, Janice⋅Blum, Janice⋅Blum, Janice⋅Blum, Janice⋅Blum, Janice⋅Blum, J.⋅Blum, Janice⋅Morris, Margaret A⋅Morris, Margaret A⋅Morris, Margaret A⋅Morris, Margaret A⋅Morris, M.A.⋅Morris, Margaret A⋅Morris, Margaret A⋅Mirmira, Raghavendra G⋅Mirmira, Raghavendra G⋅Mirmira, Raghavendra G⋅Mirmira, Raghavendra G⋅Mirmira, Raghavendra G⋅Mirmira, R.G.⋅Mirmira, Raghavendra G⋅Nadler, Jerry⋅Nadler, J.⋅Nadler, Jerry⋅Nadler, Jerry⋅Nadler, Jerry⋅Nadler, Jerry⋅Nadler, Jerry⋅Mastracci, Teresa L⋅Mastracci, Teresa L⋅Mastracci, Teresa L⋅Mastracci, T.L.⋅Mastracci, Teresa L⋅Mastracci, Teresa L⋅Mastracci, Teresa L⋅Marcovina, Santica⋅Marcovina, Santica⋅Marcovina, Santica⋅Marcovina, Santica⋅Marcovina, Santica⋅Marcovina, Santica⋅Marcovina, S.⋅Qian, Wei-Jun⋅Qian, Wei-Jun⋅Qian, Wei-Jun⋅Qian, Wei-Jun⋅Qian, Wei-Jun⋅Qian, Wei-Jun⋅Qian, W.-J.⋅Yi, L.⋅Yi, Lian⋅Yi, Lian⋅Yi, Lian⋅Yi, Lian⋅Yi, Lian⋅Yi, Lian⋅Swensen, Adam C⋅Swensen, Adam C⋅Swensen, Adam C⋅Swensen, Adam C⋅Swensen, Adam C⋅Swensen, A.C.⋅Swensen, Adam C⋅Yip-Schneider, Michele⋅Yip-Schneider, Michele⋅Yip-Schneider, Michele⋅Yip-Schneider, M.⋅Yip Schneider, Michele⋅Yip-Schneider, Michele⋅Yip-Schneider, Michele⋅Schmidt, C Max⋅Schmidt, C Max⋅Schmidt, C Max⋅Schmidt, C Max⋅Schmidt, C Max⋅Max Schmidt, C.⋅Schmidt, C Max⋅Considine, R.V.⋅Considine, Robert V⋅Considine, Robert V⋅Considine, Robert V⋅Considine, Robert V⋅Considine, Robert V⋅Considine, Robert V⋅Arvan, Peter⋅Arvan, Peter⋅Arvan, Peter⋅Arvan, Peter⋅Arvan, Peter⋅Arvan, P.⋅Arvan, Peter⋅Greenbaum, Carla J⋅Greenbaum, Carla J⋅Greenbaum, Carla J⋅Greenbaum, Carla J⋅Greenbaum, C.J.⋅Greenbaum, Carla J⋅Greenbaum, Carla J⋅Evans-Molina, Carmella⋅Evans-Molina, Carmella⋅Evans-Molina, Carmella⋅Evans Molina, Carmella⋅Evans-Molina, Carmella⋅Evans-Molina, C. and Evans-Molina, Carmella
Diabetes Care, vol. 42, pp. E85-E86. | Journal Article
 
Recessive Rare Variants in Deoxyhypusine Synthase, an Enzyme Involved in the Synthesis of Hypusine, Are Associated with a Neurodevelopmental Disorder
Ganapathi, M.⋅Ganapathi, Mythily⋅Ganapathi, Mythily⋅Padgett, Leah R⋅Padgett, L.R.⋅Padgett, Leah R⋅Yamada, K.⋅Yamada, Kentaro⋅Yamada, Kentaro⋅Devinsky, Orrin⋅Devinsky, Orrin⋅Devinsky, O.⋅Willaert, R.⋅Willaert, Rebecca⋅Willaert, Rebecca⋅Person, Richard⋅Person, Richard⋅Person, R.⋅Au, P.-Y.B.⋅Au, Ping-Yee Billie⋅Au, Ping-Yee Billie⋅Tagoe, J.⋅Tagoe, Julia⋅Tagoe, Julia⋅McDonald, Marie⋅McDonald, Marie⋅McDonald, M.⋅Karlowicz, D.⋅Karlowicz, Danielle⋅Karlowicz, Danielle⋅Wolf, B.⋅Wolf, Barry⋅Wolf, Barry⋅Lee, Joanna⋅Lee, Joanna⋅Lee, J.⋅Shen, Yufeng⋅Shen, Y.⋅Shen, Yufeng⋅Okur, Volkan⋅Okur, V.⋅Okur, Volkan⋅Deng, Liyong⋅Deng, Liyong⋅Deng, L.⋅LeDuc, Charles A⋅LeDuc, C.A.⋅LeDuc, Charles A⋅Wang, J.⋅Wang, Jiayao⋅Wang, Jiayao⋅Hanner, Ashleigh⋅Hanner, Ashleigh⋅Hanner, A.⋅Mirmira, Raghavendra G⋅Mirmira, Raghavendra G⋅Mirmira, R.G.⋅Park, Myung Hee⋅Park, M.H.⋅Park, Myung Hee⋅Mastracci, Teresa L⋅Mastracci, Teresa L⋅Mastracci, T.L.⋅Chung, W.K.⋅Chung, Wendy K and Chung, Wendy K
American Journal of Human Genetics, vol. 104, pp. 287-298. | Journal Article
2018
Distinct gene expression pathways in islets from individuals with short- and long-duration type 1 diabetes
Mastracci, Teresa L.⋅Turatsinze, Jean-Valery⋅Book, Benita K.⋅Restrepo, Ivan A.⋅Pugia, Michael J.⋅Wiebke, Eric A.⋅Pescovitz, Mark D.⋅Eizirik, Decio L. and Mirmira, Raghavendra G.
Diabetes, Obesity and Metabolism. | Journal Article
2017
Pancreatic ? cell identity requires continual repression of non-? cell programs
Gutiérrez, G.D.⋅Bender, A.S.⋅Cirulli, V.⋅Mastracci, T.L.⋅Kelly, S.M.⋅Tsirigos, A.⋅Kaestner, K.H. and Sussel, L.
Journal of Clinical Investigation, vol. 127, pp. 244-259. | Journal Article
2016
An insulin signaling feedback loop regulates pancreas progenitor cell differentiation during islet development and regeneration
Ye, L.⋅Robertson, M.A.⋅Mastracci, T.L. and Anderson, R.M.
Developmental Biology, vol. 409, pp. 354-369. | Journal Article
 
Model systems: A continual window into human disease?
Mastracci, T.L.
Endocrinology, vol. 157, pp. 4550-4552. | Journal Article
 
The novel enterochromaffin marker Lmx1a regulates serotonin biosynthesis in enteroendocrine cell lineages downstream of Nkx2.2
Gross, S.⋅Garofalo, D.C.⋅Balderes, D.A.⋅Mastracci, T.L.⋅Dias, J.M.⋅Perlmann, T.⋅Ericson, J. and Sussel, L.
Development (Cambridge), vol. 143, pp. 2616-2628. | Journal Article