192 Publications (Page 1 of 8)
2023
Engineering Metastability into a Virus-like Particle to Enable Triggered Dissociation. Journal of the American Chemical Society
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New tricks for old molecules: A newly discovered modality for CAMs may yet lead to an HBV cure. Hepatology
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Structure of the Hepatitis B virus capsid quasi-6-fold with a trapped C-terminal domain reveals capsid movements associated with domain exit. Journal of Biological Chemistry
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2022
Core Protein-Directed Antivirals and Importin \upbeta Can Synergistically Disrupt HBV CapsidsKim, Christine⋅Barnes, Lauren F.⋅Schlicksup, Christopher J.⋅Patterson, Angela J.⋅Bothner, Brian B.⋅Jarrold, Martin F.⋅Wang, Che-Yen Joseph and Zlotnick, AdamJournal of Virology.
| Journal Article
Core Protein-Directed Antivirals and Importin \upbeta Can Synergistically Disrupt Hepatitis B Virus CapsidsKim, Christine⋅Barnes, Lauren F.⋅Schlicksup, Christopher J.⋅Patterson, Angela J.⋅Bothner, Brian⋅Jarrold, Martin F.⋅Wang, Che-Yen Joseph and Zlotnick, AdamJournal of Virology, vol. 96.
| Journal Article
Hysteresis in Hepatitis B Virus (HBV) Requires Assembly of Near-Perfect Capsids
Biochemistry. | Journal Article
In-Plane, In-Series Nanopores with Circular Cross Sections for Resistive-Pulse SensingZhang, Mi⋅Harms, Zachary D.⋅Greibe, Tine⋅Starr, Caleb A.⋅Zlotnick, Adam and Jacobson, Stephen C.ACS Nano.
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Nomenclature of HBV core protein-targeting antivirals. Nature Reviews Gastroenterology & Hepatology
2021
Asymmetrizing an icosahedral virus capsid by hierarchical assembly of subunits with designed asymmetry⋅⋅Zhang, Mi⋅Zhang, Mi⋅Lyktey, Nicholas A⋅Lyktey, Nicholas A⋅Jarrold, Martin F⋅Jarrold, Martin F⋅Jacobson, Stephen C⋅Jacobson, Stephen C⋅Zlotnick, Adam and Zlotnick, AdamNature Communications.
| Journal Article
Core Protein-Directed Antivirals and Importinβ Can Synergistically Disrupt HBV Capsids
Disassembly of Single Virus Capsids Monitored in Real Time with Multicycle Resistive-Pulse Sensing
Analytical Chemistry. | Journal Article
HBV Core Protein Is in Flux between Cytoplasmic, Nuclear, and Nucleolar Compartments
mBio. | Journal Article
Virus self-assembly proceeds through contact-rich energy minima
Science Advances. | Journal Article
2020
Dynamics of Hepatitis B virus capsid protein dimer regulate assembly through an allosteric networkPatterson, Angela⋅Zhao, Zhongchao⋅Waymire, Elizabeth⋅Zlotnick, Adam and Bothner, BrianACS Chemical Biology.
| Journal Article
Higher Resolution Charge Detection Mass Spectrometry
Analytical Chemistry. | Journal Article
Local stabilization of subunit-subunit contacts causes global destabilization of Hepatitis B virus capsidsSchlicksup, Christopher John⋅Laughlin, Patrick⋅Dunkelbarger, Steven⋅Wang, Joseph Che-Yen and Zlotnick, AdamACS Chemical Biology.
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Rapidly Forming Early Intermediate Structures Dictate the Pathway of Capsid AssemblyAsor, Roi⋅Schlicksup, Christopher John⋅Zhao, Zhongchao⋅Zlotnick, Adam and Raviv, UriJournal of the American Chemical Society.
| Journal Article
Revealing in real-time a multistep assembly mechanism for SV40 virus-like particles
Science Advances. | Journal Article
The integrity of the intradimer interface of the Hepatitis B Virus capsid protein dimer regulates capsid self-assemblyZhao, Zhongchao⋅Hadden Perilla, J.A.⋅Zlotnick, A.⋅Wang, Joseph Che-Yen⋅Segura, Carolina Perez⋅Zhao, Z.⋅Wang, J.C.-Y.⋅Hadden-Perilla, Jodi A⋅Segura, C.P. and Zlotnick, AdamACS Chemical Biology.
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Uncovering the Self-Assembly Mechanism of Hepatitis B Virus at the Single-Molecule LevelBuzón, Pedro⋅Maity, Sourav⋅Christodoulis, Panagiotis⋅Wiertsema, Monique J⋅Dunkelbarger, Steven⋅Kim, Christine⋅Wuite, Gijs J⋅Zlotnick, Adam and Roos, Wouter HBiophysical Journal, vol. 118, (no. 3), pp. 200a, 2020-02-07.
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2019
Analytical Techniques to Characterize the Structure, Properties, and Assembly of Virus CapsidsKondylis, Panagiotis⋅Kondylis, Panagiotis⋅Schlicksup, Christopher J⋅Schlicksup, Christopher J⋅Zlotnick, Adam⋅Zlotnick, Adam⋅Jacobson, Stephen C and Jacobson, Stephen CAnalytical chemistry, vol. 91, (no. 1), pp. 636, 2019-Jan-02.
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Assembly Reactions of Hepatitis B Capsid Protein into Capsid Nanoparticles Follow a Narrow Path Through a Complex Reaction LandscapeAsor, Roi⋅Asor, Roi⋅Selzer, Lisa⋅Selzer, Lisa⋅Schlicksup, Christopher John⋅Schlicksup, Christopher John⋅Zhao, Zhongchao⋅Zhao, Zhongchao⋅Zlotnick, Adam⋅Zlotnick, Adam⋅Raviv, Uri and Raviv, UriACS nano, vol. 13, (no. 7), pp. 7626, 2019-Jun-07.
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Competition between Normative and Drug-Induced Virus Self-Assembly Observed with Single-Particle MethodsKondylis, Panagiotis⋅Kondylis, Panagiotis⋅Schlicksup, Christopher J⋅Schlicksup, Christopher J⋅Brunk, Nicholas E⋅Brunk, Nicholas E⋅Zhou, Jinsheng⋅Zhou, Jinsheng⋅Zlotnick, Adam⋅Zlotnick, Adam⋅Jacobson, Stephen C and Jacobson, Stephen CJournal of the American Chemical Society, vol. 141, (no. 3), pp. 1260, 2019-Jan-23.
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Evolution of Intermediates during Capsid Assembly of Hepatitis B Virus with Phenylpropenamide-Based AntiviralsKondylis, Panagiotis⋅Kondylis, Panagiotis⋅Schlicksup, Christopher J⋅Schlicksup, Christopher J⋅Katen, Sarah P⋅Katen, Sarah P⋅Lee, Lye Siang⋅Lee, Lye Siang⋅Zlotnick, Adam⋅Zlotnick, Adam⋅Jacobson, Stephen C and Jacobson, Stephen CACS infectious diseases, vol. 5, (no. 5), pp. 777, 2019-May-10.
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Identification of Chikungunya virus nucleocapsid core assembly modulatorsJones-Burrage, Sara E.⋅Tan, Zhenning⋅Li, Lichun⋅Zlotnick, Adam and Mukhopadhyay, SuchetanaCold Spring Harbor Laboratory