65 Publications (Page 1 of 3)
2021
Raloxifene reduces sex- and age-related intervertebral disc degeneration in mice by estrogen signalingBhadouria, Neharika⋅Bhadouria, Neharika⋅Bhadouria, Neharika⋅Niziolek, Paul⋅Niziolek, Paul⋅Niziolek, Paul⋅Jordi, Omar El⋅Jordi, Omar El⋅Jordi, Omar El⋅Berman, Alicia G⋅Berman, Alicia G⋅Berman, Alicia G⋅McKinzie, David⋅McKinzie, David⋅Mc Kinzie, David⋅Wallace, Joseph M⋅Wallace, Joseph M⋅Wallace, Joseph M⋅Holguin, Nilsson⋅Holguin, Nilsson and Holguin, NilssonCold Spring Harbor Laboratory
2020
Genetic Background and Sex: Impact on Generalizability of Research Findings in Pharmacology StudiesSukoff Rizzo, Stacey J⋅McTighe, Stephanie and Mc Kinzie, David LHandbook of experimental pharmacology, vol. 257, pp. 147, 2020-00-00.
| Journal Article
2018
P1‐114: MEASUREMENT OF ENDOGENOUS MOUSE TAU IN CEREBROSPINAL FLUID FROM AGED PDAPP MICE FOLLOWING TREATMENT WITH AB‐LOWERING COMPOUNDSReising, Nicholas C⋅Day, Theresa A⋅Hole, Justin T⋅Tingley, Francis David⋅Gonzalez-DeWhitt, Patricia A⋅Mergott, Dustin J⋅Mc Kinzie, David L⋅Demattos, Ronald B⋅Hayashi, Mansuo L and Riddell, David RAlzheimer's & Dementia, vol. 14, (no. 7S_Part_5), pp. P314, July 2018.
| Journal Article
2014
LY2456302 is a novel, potent, orally-bioavailable small molecule kappa-selective antagonist with activity in animal models predictive of efficacy in mood and addictive disorders.Rorick-Kehn, Linda M⋅Witkin, Jeffrey M⋅Statnick, Michael A⋅Eberle, Elizabeth L⋅McKinzie, Jamie H⋅Kahl, Steven D⋅Forster, Beth M⋅Wong, Conrad J⋅Li, Xia⋅Crile, Robert S⋅Shaw, David B⋅Sahr, Allison E⋅Adams, Benjamin L⋅Quimby, Steven J⋅Diaz, Nuria⋅Jimenez, Alma⋅Pedregal, Concepcion⋅Mitch, Charles H⋅Knopp, Kelly L⋅Anderson, Wesley H⋅Cramer, Jeffrey W and Mc Kinzie, David LNeuropharmacology, vol. 77, pp. 131-44, 2014/Feb.
| Journal Article
2013
Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator.Hao, Junliang⋅Dehlinger, Veronique⋅Fivush, Adam M⋅Rudyk, Helene C⋅Britton, Thomas C⋅Hollinshead, Sean P⋅Vokits, Benjamin P⋅Clark, Barry P⋅Henry, Steven S⋅Massey, Steven M⋅Peng, Langu⋅Dressman, Bruce A⋅Heinz, Beverly A⋅Roberts, Edda F⋅Bracey-Walker, Mallorie R⋅Swanson, Steven⋅Catlow, John T⋅Love, Patrick L⋅Tepool, Anita D⋅Peters, Steven C⋅Simmons, Rosa M⋅Iyengar, Smriti⋅Mc Kinzie, David L and Monn, James ABioorganic & medicinal chemistry letters, vol. 23, (no. 5), pp. 1249-52, 2013/Mar/1.
| Journal Article
Synthesis and pharmacological characterization of 4-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: identification of new potent and selective metabotropic glutamate 2/3 receptor agonists.Monn, James A⋅Valli, Matthew J⋅Massey, Steven M⋅Hao, Junliang⋅Reinhard, Matthew R⋅Bures, Mark G⋅Heinz, Beverly A⋅Wang, Xushan⋅Carter, Joan H⋅Getman, Brian G⋅Stephenson, Gregory A⋅Herin, Marc⋅Catlow, John T⋅Swanson, Steven⋅Johnson, Bryan G⋅Mc Kinzie, David L and Henry, Steven SJournal of medicinal chemistry, vol. 56, (no. 11), pp. 4442-55, 2013/Jun/13.
| Journal Article
The muscarinic acetylcholine receptor agonist BuTAC mediates antipsychotic-like effects via the M4 subtype.Watt, Marla L⋅Rorick-Kehn, Linda⋅Shaw, David B⋅Knitowski, Karen M⋅Quets, Anne T⋅Chesterfield, Amy K⋅Mc Kinzie, David L and Felder, Christian CNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, vol. 38, (no. 13), pp. 2717-26, 2013/Dec.
| Journal Article
2012
Effects of naltrexone and LY255582 on ethanol maintenance, seeking, and relapse responding by alcohol-preferring (P) rats.Dhaher, Ronnie⋅Toalston, Jamie E⋅Hauser, Sheketha R⋅Bell, Richard L⋅Mc Kinzie, David L⋅Mc Bride, William J and Rodd, Zachary AAlcohol (Fayetteville, N.Y.), vol. 46, (no. 1), pp. 17-27, 2012/Feb.
| Journal Article
Group II metabotropic glutamate receptor agonists and positive allosteric modulators as novel treatments for schizophreniaFell, Matthew J⋅Mc Kinzie, David L⋅Monn, James A and Svensson, Kjell ANeuropharmacology, vol. 62, (no. 3), pp. 1473-1483, 2012.
| Journal Article
Muscarinic mechanisms in psychotic disorders.Mc Kinzie, David L and Bymaster, Frank PHandbook of experimental pharmacology, (no. 213), pp. 233-65, 2012.
| Journal Article
The long-lasting effects of JDTic, a kappa opioid receptor antagonist, on the expression of ethanol-seeking behavior and the relapse drinking of female alcohol-preferring (P) rats.Deehan, Gerald A⋅Mc Kinzie, David L⋅Carroll, F I⋅Mc Bride, William J and Rodd, Zachary APharmacology, biochemistry, and behavior, vol. 101, (no. 4), pp. 581-7, 2012/Jun.
| Journal Article
2011
Discovery of aminobenzyloxyarylamides as κ opioid receptor selective antagonists: application to preclinical development of a κ opioid receptor antagonist receptor occupancy tracer.Mitch, Charles H⋅Quimby, Steven J⋅Diaz, Nuria⋅Pedregal, Concepcion⋅de la Torre, Marta G⋅Jimenez, Alma⋅Shi, Qing⋅Canada, Emily J⋅Kahl, Steven D⋅Statnick, Michael A⋅Mc Kinzie, David L⋅Benesh, Dana R⋅Rash, Karen S and Barth, Vanessa NJournal of medicinal chemistry, vol. 54, (no. 23), pp. 8000-12, 2011/Dec/8.
| Journal Article
2010
Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties.Leach, Katie⋅Loiacono, Richard E⋅Felder, Christian C⋅Mc Kinzie, David L⋅Mogg, Adrian⋅Shaw, David B⋅Sexton, Patrick M and Christopoulos, ArthurNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, vol. 35, (no. 4), pp. 855-69, 2010/Mar.
| Journal Article
The Orexin-1 Receptor Antagonist SB-334867 Reduces Alcohol Relapse Drinking, but not Alcohol-Seeking, in Alcohol-Preferring (P) Rats.Dhaher, Ronnie⋅Dhaher, Ronnie⋅Hauser, Sheketha R⋅Hauser, Sheketha R⋅Getachew, Bruk⋅Getachew, Bruk⋅Bell, Richard L⋅Bell, Richard L⋅McBride, William J⋅Mc Bride, William J⋅McKinzie, David L⋅Mc Kinzie, David L⋅Rodd, Zachary A and Rodd, Zachary AJournal of addiction medicine, vol. 4, (no. 3), pp. 153-9, 2010/Sep.
| Journal Article
2009
In vitro and in vivo evidence for a lack of interaction with dopamine D2 receptors by the metabotropic glutamate 2/3 receptor agonists 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-bicaroxylate monohydrate (LY354740) and (-)-2-oxa-4-aminobicyclo[3.1.0] Hexane-4,6-dicarboxylic acid (LY379268).Fell, Matthew J⋅Perry, Kenneth W⋅Falcone, Julie F⋅Johnson, Bryan G⋅Barth, Vanessa N⋅Rash, Karen S⋅Lucaites, Virginia L⋅Threlkeld, Penny G⋅Monn, James A⋅Mc Kinzie, David L⋅Marek, Gerard J⋅Svensson, Kjell A and Nelson, David LThe Journal of pharmacology and experimental therapeutics, vol. 331, (no. 3), pp. 1126-36, 2009/Dec.
| Journal Article
Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond.Ciccocioppo, Roberto⋅Ciccocioppo, Roberto⋅Gehlert, Donald R.⋅Gehlert, Donald R⋅Ryabinin, Andrey⋅Ryabinin, Andrey⋅Kaur, Simranjit⋅Kaur, Simranjit⋅Cippitelli, Andrea⋅Cippitelli, Andrea⋅Thorsell, Annika⋅Thorsell, Annika⋅Lê, Anh D⋅Lê, Anh D.⋅Hipskind, Philip A⋅Hipskind, Philip A.⋅Hamdouchi, Chafiq⋅Hamdouchi, Chafiq⋅Lu, Jianliang⋅Lu, Jianliang⋅Hembre, Erik J⋅Hembre, Erik J.⋅Cramer, Jeffrey⋅Cramer, Jeffrey⋅Song, Min⋅Song, Min⋅Mc Kinzie, David L⋅McKinzie, David⋅Morin, Michelle⋅Morin, Michelle⋅Economidou, Daina⋅Economidou, Daina⋅Stopponi, Serena⋅Stopponi, Serena⋅Cannella, Nazzareno⋅Cannella, Nazzareno⋅Braconi, Simone⋅Braconi, Simone⋅Kallupi, Marsida⋅Kallupi, Marsida⋅de Guglielmo, Giordano⋅de Guglielmo, Giordano⋅Massi, Maurizio⋅Massi, Maurizio⋅George, David T⋅George, David T.⋅Gilman, Jody⋅Gilman, Jody⋅Hersh, Jacqueline R⋅Hersh, Jacqueline⋅Tauscher, Johannes T.⋅Tauscher, Johannes T⋅Hunt, Stephen P⋅Hunt, Stephen P.⋅Hommer, Daniel⋅Hommer, Daniel⋅Heilig, Markus and Heilig, MarkusAlcohol (Fayetteville, N.Y.), vol. 43, (no. 7), pp. 491-8, 2009/Nov.
| Journal Article
2008
Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia.Chan, W Y⋅Mc Kinzie, David L⋅Bose, S⋅Mitchell, S N⋅Witkin, J M⋅Thompson, R C⋅Christopoulos, Arthur⋅Lazareno, S⋅Birdsall, N J⋅Bymaster, F P and Felder, C CProceedings of the National Academy of Sciences of the United States of America, vol. 105, (no. 31), pp. 10978-83, 2008/Aug/5.
| Journal Article
Autonomic activation associated with ethanol self-administration in adult female P rats.Bell, Richard⋅Rodd, Zachary A⋅Toalston, Jamie E⋅Mc Kinzie, David L⋅Lumeng, Lawrence⋅Li, Ting Kai⋅Mc Bride, William J and Murphy, James MPharmacology, biochemistry, and behavior, vol. 91, (no. 2), pp. 223-32, 2008/Dec.
| Journal Article
Selective Muscarinic Receptor Agonist Xanomeline as a Novel Treatment Approach for SchizophreniaShekhar, Anantha⋅Potter, William Z⋅Lightfoot, Jeffrey⋅Lienemann, John⋅Dubé, Sanjay⋅Mallinckrodt, Craig⋅Bymaster, Frank P⋅Mc Kinzie, David L and Felder, Christian CThe American Journal of Psychiatry, vol. 165, (no. 8), pp. 1033-9, Aug 2008.
| Journal Article
2007
Effects of kappa opioid receptor agonists on attention as assessed by a 5-choice serial reaction time task in rats.Shannon, Harlan E⋅Eberle, Elizabeth L⋅Mitch, Charles H⋅Mc Kinzie, David L and Statnick, Michael ANeuropharmacology, vol. 53, (no. 8), pp. 930-41, 2007/Dec.
| Journal Article
In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disordersRorick-Kehn, Linda M⋅Johnson, Bryan G⋅Knitowski, Karen M⋅Salhoff, Craig R⋅Witkin, Jeffrey M⋅Perry, Kenneth W⋅Griffey, Kelly I⋅Tizzano, Joseph P⋅Monn, James A⋅Mc Kinzie, David L and Schoepp, Darryle DPsychopharmacology, vol. 193, (no. 1), pp. 121-36, Jul 2007.
| Journal Article
Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (LY404039).Rorick-Kehn, Linda M⋅Johnson, Bryan G⋅Burkey, Jennifer L⋅Wright, Rebecca A⋅Calligaro, David O⋅Marek, Gerard J⋅Nisenbaum, Eric S⋅Catlow, John T⋅Kingston, Ann E⋅Giera, Deborah D⋅Herin, Marc F⋅Monn, James A⋅Mc Kinzie, David L and Schoepp, Darryle DThe Journal of pharmacology and experimental therapeutics, vol. 321, (no. 1), pp. 308-17, 2007/Apr.
| Journal Article
2006
Improved bioavailability of the mGlu2/3 receptor agonist LY354740 using a prodrug strategy: in vivo pharmacology of LY544344.Rorick-Kehn, Linda M⋅Rorick-Kehn, Linda M⋅Perkins, Everett J⋅Perkins, Everett J⋅Knitowski, Karen M⋅Knitowski, Karen M⋅Hart, John C⋅Hart, John C⋅Johnson, Bryan G⋅Johnson, Bryan G⋅Schoepp, Darryle D⋅Schoepp, Darryle D⋅Mc Kinzie, David L and McKinzie, David LThe Journal of pharmacology and experimental therapeutics, vol. 316, (no. 2), pp. 905-13, 2006/Feb.
| Journal Article
Melanin-Concentrating Hormone-1 Receptor Modulates Neuroendocrine, Behavioral, and Corticolimbic Neurochemical Stress Responses in MiceSmith, Daniel G⋅Davis, Richard J⋅Rorick-Kehn, Linda⋅Morin, Michelle⋅Witkin, Jeffrey M⋅Mc Kinzie, David L⋅Nomikos, George G and Gehlert, Donald RNeuropsychopharmacology, vol. 31, (no. 6), pp. 1135-45, Jun 2006.
| Journal Article
Preclinical evaluation of melanin-concentrating hormone-1 receptor antagonist for the treatment of obesity and psychiatric disordersGehlert, D.R⋅Davis, Richard J⋅Rorick-Kehn, Linda⋅Witkin, Jeffrey M⋅Mc Kinzie, David L⋅Song, Min⋅Morin, Michelle⋅Nomikos, George G and Smith, Daniel GNeuropeptides, vol. 40, (no. 6), pp. 429, 2006.
| Journal Article