Expertise

The mechanism of action of interferon, cancer gene therapy with adenovirus and adeno-associated virus vectors carrying the interferon genes and the genes of other cytokines, and identification of specific tumor markers using PCR and DNA array. Cell culture techniques. I have taught cell culture and virology lab and lecture for the last 25 years;
Gene therapy using adenovirus
Molecular Biology, particularly of viruses and RNA
Interferon : mode of action. Interaction with other cytokines
Role of Indoleamine 2,3 dioxygenase in the interferon response and in immunity
DNA micro-arrays ( affymetrix)
Research into hepatitis C, and clinical response to treatment
Cell culture techniques. I have taught cell culture and virology lab and lecture for the last 25 years;
Gene therapy using adenovirus
Molecular Biology, particularly of viruses and RNA
Interferon : mode of action. Interaction with other cytokines
Role of Indoleamine 2,3 dioxygenase in the interferon response and in immunity
DNA micro-arrays ( affymetrix)
Research into hepatitis C, and clinical response to treatment

Gene Therapy with Adenovirus
Somatic cell genetics
Purine metabolism

Biology, Cellular, Biotechnology, Birth/Congenital Defects, Dengue Virus, Disease Entities/Medical Problems, Behavior, Genetic Manipulation, Hepatitis C, Immunology, Immunotherapy, Interferons, Metabolic Diseases

Have worked at Amgen in licensing and administration
Consultant for NGI. Have been consultant for other companies

DNA microarrays may identify novel genes of clinical use

Perform DNA microarrays and cytokine assays to examine differential responses to interferontherapy in hepatitis C patients
Synergy between interferon gamma and interferon alpha

Affiliations

Professor, Biology and Microbiology, College of Arts and Sciences, Indiana University Bloomington

Past Affiliations

Postdoctoral Fellow, University of California Irvine
1961 - 1967

Professor, Biochemistry Interdisciplinary Graduate Program, Molecular and Cellular Biochemistry Department, College of Arts and Sciences, Indiana University Bloomington

Professor Emeritus, Department of Biology, College of Arts and Sciences, Indiana University Bloomington

Professor, Department of Biology, College of Arts and Sciences, Indiana University Bloomington

Professor, Melvin and Bren Simon Cancer Center, Indiana University-Purdue University Indianapolis, School of Medicine (past)

Fellow, Indiana Molecular Biology Institute, College of Arts and Sciences, Indiana University Bloomington

Assistant-Full Professor, Indiana University

Melvin and Bren Simon Cancer Center, Indiana University-Purdue University Indianapolis, School of Medicine (past)
current

Communities
Oncology, Microbiology
Degrees
PhD, Stanford University, Biology, 1966
BS, Cornell University, Agriculture, 1961
PhD
Keywords
biotechnology immunology cancer biology metabolic diseases breast cancer hepatitis immunotherapy gene therapy gene cloning genetic manipulation molecular cloning recombinant dna gene regulation gene expression cell lines tissue culture virology
Languages
Hebrew
Associations
American Academy of Microbiology
American Association for Cancer Research
American Society for Microbiology
American Society for Virology