CDNA cloning, in situ hybridization, immunocytochemical localization, quantitation, characterization, metabolism, and receptor activity of hypothalamic and extra hypothalamic neuroactive peptides and their effects on neuroendocrine function, neurologic and affective disorders and epilepsy. Specific peptides under investigation are thyrotropin-releasing hormone (TRH), Gonadotropin-releasing hormone (GnRH), Beta-endorphin and leucine enkephalin with major emphasis on TRH.
