Our research focuses on the pathogenesis of neuronal injury after cerebral ischemia or traumatic brain injury using in vivo and in vitro preparations. Excitotoxicity is the major cause of neuronal damage in many neurological disorders such as stroke and traumatic brain injury. Imbalance of excitation and inhibition also results in epilepsy. The excitablity of the brain is determined by synaptic transmission and neuronal membrane property. Recent study also indicates that inflammation also plays an important role in neuronal injury in many neurological disorders. The research in my lab is to reveal the role of alteration of neuronal excitability in pathogenesis of neurological disorders.
- Stroke is the leading cause of death and disability in U.S.
- Seizure/epilepsy is a common sequela of acute neurological disorders including stroke and traumatic brain injury.
Alternation of neuronal excitability in neurological disorders.
