Expertise

My research interests include understanding how dysregulated cellular signaling pathways drive pancreatic tumorigenesis.  Specifically, the pathway regulated by the transcription factor nuclear factor-kappaB (NF-kB) has been demonstrated to play a critical role in the development and progression of pancreatic cancer.  Thus, we have been investigating the NF-kB pathway as a promising target.  For these translational studies, our laboratory employs several pre-clinical animal models (standard flank tumor and patient pancreatic tumor tissue xenografts, carcinogen-induced hamster model, genetically engineered mice) to evaluate the chemopreventative and chemotherapeutic potential of various agents for the treatment of pancreatic cancer.

Past Affiliations
Communities
Oncology, Surgery
Degrees
PhD, University of California, Davis, Biochemistry, 1988
AB, University of California, Berkeley, Biochemistry, 1982