189 Publications (Page 7 of 8)
2008
Relationship of cytochrome P450 pharmacogenetics to the effects of yohimbine on gastrointestinal transit and catecholamines in healthy subjectsbharucha, ae⋅Skaar, Todd⋅andrews, cn⋅Camilleri, Michael⋅philips, s.⋅seide, b.⋅burton, d.⋅baxter, k. and zinsmeister, arNeurogastroenterology and Motility, vol. 20, (no. 8), pp. 891-899, 2008.
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2007
The A4396G polymorphism in interferon regulatory factor 1 is frequently expressed in breast cancer cell lines.Bouker, Kerrie B⋅Skaar, Todd C⋅Harburger, David S⋅Riggins, Rebecca B⋅Fernandez, David R⋅Zwart, Alan and Clarke, RobertCancer genetics and cytogenetics, vol. 175, (no. 1), pp. 61-4, 2007/May.
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2006
Analysis of angiogenesis genes from paraffin-embedded breast tumor and lymph nodesSchneider, Bryan P⋅Skaar, Todd⋅Sledge, George W⋅Badve, Sunil S⋅Li, Lang and Flockhart, David ABreast Cancer Research and Treatment, vol. 96, (no. 3), pp. 209-15, Apr 2006.
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Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells.Lim, Young C⋅Li, Lang⋅Desta, Zeruesenay⋅Zhao, Qianqian⋅Rae, James⋅Flockhart, David A and Skaar, Todd CThe Journal of pharmacology and experimental therapeutics, vol. 318, (no. 2), pp. 503-12, 2006/Aug.
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Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment.Borges, Silvana⋅Desta, Zeruesenay⋅Li, Lang⋅Skaar, Todd C⋅Ward, Bryan A⋅Nguyen, Anne⋅Jin, Yan⋅Storniolo, Anna M⋅Nikoloff, D M⋅Wu, Lin⋅Hillman, Grant⋅Hayes, Daniel F⋅Stearns, Vered and Flockhart, David AClinical pharmacology and therapeutics, vol. 80, (no. 1), pp. 61-74, 2006/Jul.
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2005
Association between the CYP3A5 genotype and blood pressure.Ho, Herbert⋅Pinto, Amar⋅Hall, Stephen D⋅Flockhart, David A⋅Li, Lang⋅Skaar, Todd C⋅Cadman, Peter⋅O'connor, Daniel T⋅Wagner, Urban⋅Fineberg, Naomi S and Weinberger, Myron HHypertension, vol. 45, (no. 2), pp. 294-8, 2005/Feb.
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CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment.Jin, Yan⋅Desta, Zeruesenay⋅Stearns, Vered⋅Ward, Bryan⋅Ho, Herbert⋅Lee, Kyung-Hoon⋅Skaar, Todd C⋅Storniolo, Anna M⋅Li, Lang⋅Araba, Adjei⋅Blanchard, Rebecca⋅Nguyen, Anne⋅Ullmer, Lynda⋅Hayden, Jill⋅Lemler, Suzanne⋅Weinshilboum, Richard M⋅Rae, James⋅Hayes, Daniel F and Flockhart, David AJournal of the National Cancer Institute, vol. 97, (no. 1), pp. 30-9, 2005/Jan/5.
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Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifenLim, Young C⋅Desta, Zeruesenay⋅Flockhart, David A and Skaar, ToddCancer Chemotherapy and Pharmacology, vol. 55, (no. 5), pp. 471-8, May 2005.
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Inhibition of Human Intestinal Wall Metabolism by Macrolide Antibiotics: Effect of Clarithromycin on Cytochrome P450 3A4/5 Activity and ExpressionPinto, Amar G⋅Pinto, Amar G⋅Wang, Ying‐Hong⋅Wang, Ying-Hong⋅Chalasani, Naga P⋅Chalasani, Naga⋅Skaar, Todd⋅Skaar, Todd⋅Kolwankar, Dhanashri⋅Kolwankar, Dhanashri⋅Gorski, J C⋅Gorski, J. Christopher⋅Liangpunsakul, Suthat⋅Liangpunsakul, Suthat⋅Hamman, Mitchell A⋅Hamman, Mitchell A⋅Arefayene, Million⋅Arefayene, Million⋅Hall, Stephen D and Hall, Stephen DClinical Pharmacology & Therapeutics, vol. 77, (no. 3), pp. 188, 2005-03-00.
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Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosisBouker, Kerrie B⋅Skaar, Todd⋅Riggins, Rebecca B⋅Harburger, David S⋅Fernandez, David R⋅Zwart, Alan⋅Wang, Antai and Clarke, RobertCarcinogenesis, vol. 26, (no. 9), pp. 1527-1535, 2005.
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2004
interferon regulatory factor-1 mediates the proapoptotic but not cell cycle arrest effects of the steroidal antiestrogen ICI 182,780 (faslodex, fulvestrant).Bouker, Kerrie B⋅Skaar, Todd C⋅Fernandez, David R⋅O'Brien, Kerry A⋅Riggins, Rebecca B⋅Cao, Donghua and Clarke, RobertCancer Research, vol. 64, (no. 11), pp. 4030-9, 2004/Jun/1.
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Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen.Johnson, Michael D⋅Zuo, Hong⋅Lee, Kyung Hoon⋅Trebley, Joseph P⋅Rae, James⋅Weatherman, Ross V⋅Desta, Zeruesanay⋅Flockhart, David A and Skaar, Todd CBreast Cancer Research and Treatment, vol. 85, (no. 2), pp. 151-9, 2004/May.
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Pharmacological Characterization of 4-hydroxy- N -desmethyl Tamoxifen, a Novel Active Metabolite of TamoxifenFlockhart, David⋅Weatherman, Ross⋅Johnson, Michael⋅Zuo, Hong⋅Lee, Kyung-Hoon⋅Trebley, Joseph⋅Rae, James⋅Desta, Zeruesanay and Skaar, Todd2004-05.
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2003
Antiestrogen resistance in breast cancer and the role of estrogen receptor signalingClarke, Robert⋅Clarke, Robert⋅Liu, MC⋅Liu, Minetta C⋅Bouker, KB⋅Bouker, Kerrie B⋅Gu, Z.⋅Gu, Zhiping⋅Lee, RY⋅Lee, Richard Y⋅Zhu, Y.⋅Zhu, Yuelin⋅Skaar, Todd C⋅Skaar, Todd⋅Gomez, B.⋅Gomez, Bianca⋅O'Brien, K.⋅O'Brien, Kerry⋅Wang, Y.⋅Wang, Yue⋅Hilakivi Clarke, Leena A and Hilakivi-Clarke, Leena AOncogene, vol. 22, (no. 47), pp. 7316-7339, 2003.
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Functional characterization of the 5′-regulatory region of human CYP2C19Arefayene, Million⋅Zhao, Xiaojiong⋅Tanus‐Santos, Jose E⋅Brinkmann, Ulrich⋅Brehm, Ilka⋅Nguyen, Anne⋅Flockhart, David A and Skaar, ToddClinical Pharmacology & Therapeutics, vol. 73, (no. 2), pp. P60, 2003-02-00.
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Sequence diversity and functional characterization of the 5'-regulatory region of human CYP2C19.Arefayene, Million⋅Arefayene, Million⋅Skaar, Todd C⋅Skaar, Todd C⋅Zhao, Xiaojiong⋅Zhao, Xiaojiong⋅Rae, James⋅Rae, James M⋅Tanus Dos Santos, José Eduardo⋅Tanus-Santos, Jose E⋅Brinkmann, Ulrich⋅Brinkmann, Ulrich⋅Brehm, Ilka⋅Brehm, Ilka⋅Salat, Ulrike⋅Salat, Ulrike⋅Nguyen, Anne⋅Nguyen, Anne⋅Desta, Zeruesenay⋅Desta, Zeruesenay⋅Flockhart, David A and Flockhart, David APharmacogenetics, vol. 13, (no. 4), pp. 199-206, 2003/Apr.
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2002
Association of interferon regulatory factor-1, nucleophosmin, nuclear factor-kappaB, and cyclic AMP response element binding with acquired resistance to Faslodex (ICI 182,780).Gu, Zhiping⋅Lee, Richard Y⋅Skaar, Todd C⋅Bouker, Kerrie B⋅Welch, James N⋅Lu, Jianping⋅Liu, Aiyi⋅Zhu, Yuelin⋅Davis, Natalie⋅Leonessa, Fabio⋅Brünner, Nils⋅Wang, Yue and Clarke, RobertCancer Research, vol. 62, (no. 12), pp. 3428-37, 2002/Jun/15.
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Association of Interferon Regulatory Factor-1, Nucleophosmin, Nuclear Factor-{kappa}B, and Cyclic AMP Response Element Binding with Acquired Resistance to Faslodex (ICI 182,780)Gu, Zhiping⋅Lee, Richard⋅Skaar, Todd⋅Bouker, Kerrie⋅Welch, James⋅Lu, Jianping⋅Liu, Aiyi⋅Zhu, Yuelin⋅Davis, Natalie⋅Leonessa, Fabio⋅Brunner, Nils⋅Wang, Yue and Clarke, RobertCancer Research, vol. 62, (no. 12), pp. 3428, 20020601.
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2001
Cellular and molecular pharmacology of antiestrogen action and resistance.Clarke, Robert⋅Leonessa, F⋅Welch, J N and Skaar, Todd CPharmacological reviews, vol. 53, (no. 1), pp. 25-71, 2001/Mar.
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Constitutive expression of the steroid sulfatase gene supports the growth of MCF-7 human breast cancer cells in vitro and in vivo.James, M R⋅Skaar, Todd C⋅Lee, R Y⋅MacPherson, A⋅Zwiebel, J A⋅Ahluwalia, B S⋅Ampy, F and Clarke, RobertEndocrinology, vol. 142, (no. 4), pp. 1497-505, 2001/Apr.
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Constitutive Expression of the Steroid Sulfatase Gene Supports the Growth of MCF-7 Human Breast Cancer Cells in Vitro and in Vivo1James, Mattie R⋅Skaar, Todd C⋅Lee, Richard Y⋅MacPherson, Alexander⋅Zwiebel, James A⋅Ahluwalia, Balwant S⋅Ampy, Franklin and Clarke, RobertEndocrinology, vol. 142, (no. 4), pp. 1505, 2001-04.
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Molecular and pharmacological aspects of antiestrogen resistanceClarke, Robert⋅Skaar, Todd⋅Bouker, KB⋅Davis, N.⋅Lee, YR⋅Welch, JN and Leonessa, F.Journal of Steroid Biochemistry and Molecular Biology, vol. 76, (no. 1-3), pp. 71-84, 2001.
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Molecular and pharmacological aspects of antiestrogen resistance.Clarke, Robert⋅Skaar, Todd C⋅Bouker, K B⋅Davis, N⋅Lee, Y R⋅Welch, J N and Leonessa, FThe Journal of Steroid Biochemistry and Molecular Biology, vol. 76, (no. 1-5), pp. 71-84, 2001 Jan-Mar.
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1999
Prepubertal exposure to zearalenone or genistein reduces mammary tumorigenesis.Hilakivi Clarke, Leena⋅Onojafe, I⋅Raygada, M⋅Cho, E⋅Skaar, Todd C⋅Russo, I and Clarke, RobertBritish Journal of Cancer, vol. 80, (no. 11), pp. 1682-8, 1999/Aug.
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