189 Publications (Page 7 of 8)
2008
Relationship of cytochrome P450 pharmacogenetics to the effects of yohimbine on gastrointestinal transit and catecholamines in healthy subjects
bharucha, aeSkaar, Toddandrews, cnCamilleri, Michaelphilips, s.seide, b.burton, d.baxter, k. and zinsmeister, ar
Neurogastroenterology and Motility, vol. 20, (no. 8), pp. 891-899, 2008. | Journal Article
 
The role of single nucleotide polymorphisms in breast cancer metastasis
Rae, James MSkaar, ToddHilsenbeck, Susan G and Oesterreich, Steffi
Breast Cancer Research, vol. 10, (no. 1), pp. 301-301, 2008. | Journal Article
2007
The A4396G polymorphism in interferon regulatory factor 1 is frequently expressed in breast cancer cell lines.
Bouker, Kerrie BSkaar, Todd CHarburger, David SRiggins, Rebecca BFernandez, David RZwart, Alan and Clarke, Robert
Cancer genetics and cytogenetics, vol. 175, (no. 1), pp. 61-4, 2007/May. | Journal Article
2006
Analysis of angiogenesis genes from paraffin-embedded breast tumor and lymph nodes
Schneider, Bryan PSkaar, ToddSledge, George WBadve, Sunil SLi, Lang and Flockhart, David A
Breast Cancer Research and Treatment, vol. 96, (no. 3), pp. 209-15, Apr 2006. | Journal Article
 
Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells.
Lim, Young CLi, LangDesta, ZeruesenayZhao, QianqianRae, JamesFlockhart, David A and Skaar, Todd C
The Journal of pharmacology and experimental therapeutics, vol. 318, (no. 2), pp. 503-12, 2006/Aug. | Journal Article
 
Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment.
Borges, SilvanaDesta, ZeruesenayLi, LangSkaar, Todd CWard, Bryan ANguyen, AnneJin, YanStorniolo, Anna MNikoloff, D MWu, LinHillman, GrantHayes, Daniel FStearns, Vered and Flockhart, David A
Clinical pharmacology and therapeutics, vol. 80, (no. 1), pp. 61-74, 2006/Jul. | Journal Article
2005
Association between the CYP3A5 genotype and blood pressure.
Ho, HerbertPinto, AmarHall, Stephen DFlockhart, David ALi, LangSkaar, Todd CCadman, PeterO'connor, Daniel TWagner, UrbanFineberg, Naomi S and Weinberger, Myron H
Hypertension, vol. 45, (no. 2), pp. 294-8, 2005/Feb. | Journal Article
 
CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment.
Jin, YanDesta, ZeruesenayStearns, VeredWard, BryanHo, HerbertLee, Kyung-HoonSkaar, Todd CStorniolo, Anna MLi, LangAraba, AdjeiBlanchard, RebeccaNguyen, AnneUllmer, LyndaHayden, JillLemler, SuzanneWeinshilboum, Richard MRae, JamesHayes, Daniel F and Flockhart, David A
Journal of the National Cancer Institute, vol. 97, (no. 1), pp. 30-9, 2005/Jan/5. | Journal Article
 
Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen
Lim, Young CDesta, ZeruesenayFlockhart, David A and Skaar, Todd
Cancer Chemotherapy and Pharmacology, vol. 55, (no. 5), pp. 471-8, May 2005. | Journal Article
 
Inhibition of Human Intestinal Wall Metabolism by Macrolide Antibiotics: Effect of Clarithromycin on Cytochrome P450 3A4/5 Activity and Expression
Pinto, Amar GPinto, Amar GWang, Ying‐HongWang, Ying-HongChalasani, Naga PChalasani, NagaSkaar, ToddSkaar, ToddKolwankar, DhanashriKolwankar, DhanashriGorski, J CGorski, J. ChristopherLiangpunsakul, SuthatLiangpunsakul, SuthatHamman, Mitchell AHamman, Mitchell AArefayene, MillionArefayene, MillionHall, Stephen D and Hall, Stephen D
Clinical Pharmacology & Therapeutics, vol. 77, (no. 3), pp. 188, 2005-03-00. | Journal Article
 
Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis
Bouker, Kerrie BSkaar, ToddRiggins, Rebecca BHarburger, David SFernandez, David RZwart, AlanWang, Antai and Clarke, Robert
Carcinogenesis, vol. 26, (no. 9), pp. 1527-1535, 2005. | Journal Article
2004
interferon regulatory factor-1 mediates the proapoptotic but not cell cycle arrest effects of the steroidal antiestrogen ICI 182,780 (faslodex, fulvestrant).
Bouker, Kerrie BSkaar, Todd CFernandez, David RO'Brien, Kerry ARiggins, Rebecca BCao, Donghua and Clarke, Robert
Cancer Research, vol. 64, (no. 11), pp. 4030-9, 2004/Jun/1. | Journal Article
 
Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen.
Johnson, Michael DZuo, HongLee, Kyung HoonTrebley, Joseph PRae, JamesWeatherman, Ross VDesta, ZeruesanayFlockhart, David A and Skaar, Todd C
Breast Cancer Research and Treatment, vol. 85, (no. 2), pp. 151-9, 2004/May. | Journal Article
 
Pharmacological Characterization of 4-hydroxy- N -desmethyl Tamoxifen, a Novel Active Metabolite of Tamoxifen
Flockhart, DavidWeatherman, RossJohnson, MichaelZuo, HongLee, Kyung-HoonTrebley, JosephRae, JamesDesta, Zeruesanay and Skaar, Todd
2004-05. | Journal Article
2003
Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling
Clarke, RobertClarke, RobertLiu, MCLiu, Minetta CBouker, KBBouker, Kerrie BGu, Z.Gu, ZhipingLee, RYLee, Richard YZhu, Y.Zhu, YuelinSkaar, Todd CSkaar, ToddGomez, B.Gomez, BiancaO'Brien, K.O'Brien, KerryWang, Y.Wang, YueHilakivi Clarke, Leena A and Hilakivi-Clarke, Leena A
Oncogene, vol. 22, (no. 47), pp. 7316-7339, 2003. | Journal Article
 
Functional characterization of the 5′-regulatory region of human CYP2C19
Arefayene, MillionZhao, XiaojiongTanus‐Santos, Jose EBrinkmann, UlrichBrehm, IlkaNguyen, AnneFlockhart, David A and Skaar, Todd
Clinical Pharmacology & Therapeutics, vol. 73, (no. 2), pp. P60, 2003-02-00. | Journal Article
 
Sequence diversity and functional characterization of the 5'-regulatory region of human CYP2C19.
Arefayene, MillionArefayene, MillionSkaar, Todd CSkaar, Todd CZhao, XiaojiongZhao, XiaojiongRae, JamesRae, James MTanus Dos Santos, José EduardoTanus-Santos, Jose EBrinkmann, UlrichBrinkmann, UlrichBrehm, IlkaBrehm, IlkaSalat, UlrikeSalat, UlrikeNguyen, AnneNguyen, AnneDesta, ZeruesenayDesta, ZeruesenayFlockhart, David A and Flockhart, David A
Pharmacogenetics, vol. 13, (no. 4), pp. 199-206, 2003/Apr. | Journal Article
2002
Association of interferon regulatory factor-1, nucleophosmin, nuclear factor-kappaB, and cyclic AMP response element binding with acquired resistance to Faslodex (ICI 182,780).
Gu, ZhipingLee, Richard YSkaar, Todd CBouker, Kerrie BWelch, James NLu, JianpingLiu, AiyiZhu, YuelinDavis, NatalieLeonessa, FabioBrünner, NilsWang, Yue and Clarke, Robert
Cancer Research, vol. 62, (no. 12), pp. 3428-37, 2002/Jun/15. | Journal Article
 
Association of Interferon Regulatory Factor-1, Nucleophosmin, Nuclear Factor-{kappa}B, and Cyclic AMP Response Element Binding with Acquired Resistance to Faslodex (ICI 182,780)
Gu, ZhipingLee, RichardSkaar, ToddBouker, KerrieWelch, JamesLu, JianpingLiu, AiyiZhu, YuelinDavis, NatalieLeonessa, FabioBrunner, NilsWang, Yue and Clarke, Robert
Cancer Research, vol. 62, (no. 12), pp. 3428, 20020601. | Journal Article
2001
Cellular and molecular pharmacology of antiestrogen action and resistance.
Clarke, RobertLeonessa, FWelch, J N and Skaar, Todd C
Pharmacological reviews, vol. 53, (no. 1), pp. 25-71, 2001/Mar. | Journal Article
 
Constitutive expression of the steroid sulfatase gene supports the growth of MCF-7 human breast cancer cells in vitro and in vivo.
James, M RSkaar, Todd CLee, R YMacPherson, AZwiebel, J AAhluwalia, B SAmpy, F and Clarke, Robert
Endocrinology, vol. 142, (no. 4), pp. 1497-505, 2001/Apr. | Journal Article
 
Constitutive Expression of the Steroid Sulfatase Gene Supports the Growth of MCF-7 Human Breast Cancer Cells in Vitro and in Vivo1
James, Mattie RSkaar, Todd CLee, Richard YMacPherson, AlexanderZwiebel, James AAhluwalia, Balwant SAmpy, Franklin and Clarke, Robert
Endocrinology, vol. 142, (no. 4), pp. 1505, 2001-04. | Journal Article
 
Molecular and pharmacological aspects of antiestrogen resistance
Clarke, RobertSkaar, ToddBouker, KBDavis, N.Lee, YRWelch, JN and Leonessa, F.
Journal of Steroid Biochemistry and Molecular Biology, vol. 76, (no. 1-3), pp. 71-84, 2001. | Journal Article
 
Molecular and pharmacological aspects of antiestrogen resistance.
Clarke, RobertSkaar, Todd CBouker, K BDavis, NLee, Y RWelch, J N and Leonessa, F
The Journal of Steroid Biochemistry and Molecular Biology, vol. 76, (no. 1-5), pp. 71-84, 2001 Jan-Mar. | Journal Article
1999
Prepubertal exposure to zearalenone or genistein reduces mammary tumorigenesis.
Hilakivi Clarke, LeenaOnojafe, IRaygada, MCho, ESkaar, Todd CRusso, I and Clarke, Robert
British Journal of Cancer, vol. 80, (no. 11), pp. 1682-8, 1999/Aug. | Journal Article