Expertise

Research:

  • Inflammatory Bowel Disease
  • Ulcerative colitis
  • Crohn's Disease
  • Mucosal immunology
  • Innate immunity
  • Microbiome
  • Obesity 

Subject areas:

  • Microbiology & Immunology
  • Cancer
  • Cellular & Molecular Biology
  • Genetics & Genomics

Research Specialties:

  • Inflammatory Bowel Diseases
  • Crohn’s Disease
  • Ulcerative Colitis
  • Colon Cancer
  • Autophagy
  • Immunology
  • Obesity
  • Microbiome

The Boone lab is interested in disorders that affect the gastrointestinal tract. Our major objectives are to understand the pathogenesis of inflammatory bowel diseases (IBD; Crohn’s Disease & Ulcerative Colitis), colon cancer and obesity. Current projects include:

  • The Microbiome in Intestinal Health
  • Intestinal Epithelial Control of Intestinal Inflammation
  • Autophagy and Colon Cancer

Interests:

  • Biology of Human Intestinal Diseases

His postdoctoral training was focused on inflammatory bowel diseases and mucosal immunology, areas that continue to be his main research focus.  He is also interested in the role of the microbiome in health and gastrointestinal contributions to obesity.

Academic Interests:

Dr. Boone's laboratory uses molecular techniques and animal models to study the regulation of inflammation, particularly as it relates to host pathogen interactions in the gastrointestinal tract. His current projects are directed at understanding: (1) the role of protein modification by ubiquitin and ubiquitin-like factors in the regulation of cellular signaling; (2) the interaction of microbes with innate immune cells and (3) the role of innate immunity in inflammatory bowel diseases

Affiliations

Professor, Department of Microbiology and Immunology, Indiana University School of Medicine

Adjunct Professor, Department of Biological Sciences, College of Science, University of Notre Dame

Investigator, Center for Diabetes and Metabolic Diseases, Centers and Institutes, Indiana University School of Medicine

Professor, IUSM South Bend, Indiana University School of Medicine

Past Affiliations

Assistant Professor, Division of Gastroenterology, Department of Medicine, School of Medicine, University of California, San Francisco (past)

Associate Professor, Indiana University School of Medicine South Bend, Indiana University School of Medicine

Assistant Professor, Section of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Biological Sciences Division, University of Chicago (past)

Member, Center for Diabetes and Metabolic Diseases, Centers and Institutes, Indiana University School of Medicine

Molecular Mechanisms of Cancer, University of Chicago Medicine Comprehensive Cancer Center, Biological Sciences Division, University of Chicago (past)

Associate Professor, IUSM Bloomington, Indiana University Bloomington

Communities
Biological Science, Infectious Diseases and Immunology, Immunology, Microbiology
Degrees
PhD, University of Ottawa, Reproductive Biology, 1997
MSc, University of Waterloo, 1991
BSc, University of Waterloo, 1989