17 Publications
2022
The Chd4 subunit of the NuRD complex regulates Pdx1-controlled genes involved in \upbeta-cell function
Davidson, Rebecca K⋅Weaver, Staci A⋅Casey, Nolan⋅Kanojia, Sukrati⋅Hogarth, Elise⋅Aguirre, Rebecca Schneider⋅Sims, Emily K.⋅Evans-Molina, Carmella and Spaeth, Jason M
Journal of Molecular Endocrinology. | Journal Article
2021
The Contribution of Transcriptional Coregulators in the Maintenance of \upbeta-cell Function and Identity
Davidson, Rebecca K⋅Kanojia, Sukrati and Spaeth, Jason M
Endocrinology, vol. 162. | Journal Article
2019
B lymphocytes protect islet β cells in diabetes prone NOD mice treated with imatinib
Wilson, Christopher S.⋅Wilson, Christopher S⋅Spaeth, Jason M.⋅Spaeth, Jason M⋅Karp, Jay⋅Karp, Jay⋅Stocks, Blair T.⋅Stocks, Blair T⋅Hoopes, Emilee M⋅Hoopes, Emilee M.⋅Stein, Roland W⋅Stein, Roland W.⋅Moore, Daniel J. and Moore, Daniel J
JCI insight, vol. 5, (no. 9), 2019-Apr-09. | Journal Article
 
HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells From Donors With Type 1 Diabetes
Russell, Mark A⋅Redick, Sambra D⋅Blodgett, David M⋅Richardson, Sarah J⋅Leete, Pia⋅Krogvold, Lars⋅Dahl-Jørgensen, Knut⋅Bottino, Rita⋅Brissova, Marcela⋅Spaeth, Jason M⋅Babon, Jenny Aurielle B⋅Haliyur, Rachana⋅Powers, Alvin C⋅Yang, Chaoxing⋅Kent, Sally C⋅Derr, Alan G⋅Kucukural, Alper⋅Garber, Manuel G⋅Morgan, Noel G and Harlan, David M
Diabetes, vol. 68, (no. 5), pp. 1001, 2019-05-00. | Journal Article
 
The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet bets-Cell Function
Spaeth, Jason⋅Liu, Jin-Hua⋅Peters, Daniel⋅Guo, Min⋅Osipovich, Anna⋅Mohammadi, Fardin⋅Roy, Nilotpal⋅Bhushan, Anil⋅Magnuson, Mark⋅Hebrok, Matthias⋅Wright, Christopher and Stein, Roland
Diabetes, vol. 68, (no. 9), pp. 1806, 20190901. | Journal Article
 
The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β-Cell Function
Spaeth, Jason M.⋅Spaeth, Jason M⋅Spaeth, Jason M⋅Liu, Jin-Hua⋅Liu, Jin-Hua⋅Liu, Jin-Hua⋅Peters, Daniel⋅Peters, Daniel⋅Peters, Daniel⋅Guo, Min⋅Guo, Min⋅Guo, Min⋅Osipovich, Anna B.⋅Osipovich, Anna B⋅Osipovich, Anna B⋅Mohammadi, Fardin⋅Mohammadi, Fardin⋅Mohammadi, Fardin⋅Roy, Nilotpal⋅Roy, Nilotpal⋅Roy, Nilotpal⋅Bhushan, Anil⋅Bhushan, Anil⋅Bhushan, Anil⋅Magnuson, Mark A.⋅Magnuson, Mark A⋅Magnuson, Mark A⋅Hebrok, Matthias⋅Hebrok, Matthias⋅Hebrok, Matthias⋅Wright, Christopher V E⋅Wright, Christopher V E⋅Wright, Christopher V.E.⋅Stein, Roland⋅Stein, Roland and Stein, Roland
Diabetes, vol. 68, (no. 9), pp. 1818, 2019-09-00. | Journal Article
2018
Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19
Park, Min Ju⋅Shen, Hailian⋅Spaeth, Jason M⋅Tolvanen, Jaana H⋅Failor, Courtney⋅Knudtson, Jennifer F⋅McLaughlin, Jessica⋅Halder, Sunil K⋅Yang, Qiwei⋅Bulun, Serdar E⋅Al-Hendy, Ayman⋅Schenken, Robert S⋅Aaltonen, Lauri A and Boyer, Thomas G
The Journal of biological chemistry, vol. 293, (no. 13), pp. 4882, 2018-03-30. | Journal Article
2017
Defining a Novel Role for the Pdx1 Transcription Factor in Islet β-Cell Maturation and Proliferation During Weaning
Spaeth, Jason M⋅Spaeth, Jason M⋅Gupte, Manisha⋅Gupte, Manisha⋅Perelis, Mark⋅Perelis, Mark⋅Yang, Yu-Ping⋅Yang, Yu-Ping⋅Cyphert, Holly⋅Cyphert, Holly⋅Guo, Shuangli⋅Guo, Shuangli⋅Liu, Jin-Hua⋅Liu, Jin-Hua⋅Guo, Min⋅Guo, Min⋅Bass, Joseph⋅Bass, Joseph⋅Magnuson, Mark A⋅Magnuson, Mark A⋅Wright, Christopher⋅Wright, Christopher⋅Stein, Roland and Stein, Roland
Diabetes, vol. 66, (no. 11), pp. 2839, 2017-11-00. | Journal Article
 
Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation
Dean, E. Danielle⋅Li, Mingyu⋅Prasad, Nripesh⋅Wisniewski, Scott N.⋅Von Deylen, Alison⋅Spaeth, Jason⋅Maddison, Lisette⋅Botros, Anthony⋅Sedgeman, Leslie R.⋅Bozadjieva, Nadejda⋅Ilkayeva, Olga⋅Coldren, Anastasia⋅Poffenberger, Greg⋅Shostak, Alena⋅Semich, Michael C.⋅Aamodt, Kristie I.⋅Phillips, Neil⋅Yan, Hai⋅Bernal-Mizrachi, Ernesto⋅Corbin, Jackie D.⋅Vickers, Kasey C.⋅Levy, Shawn E.⋅Dai, Chunhua⋅Newgard, Christopher⋅Gu, Wei⋅Stein, Roland⋅Chen, Wenbiao and Powers, Alvin C.
Cell Metabolism, vol. 25, pp. 1362–1373.e5. | Journal Article
2016
Impact of Pdx1-associated chromatin modifiers on islet β-cells
Spaeth, J M⋅Spaeth, J. M.⋅Walker, E M⋅Walker, E. M.⋅Stein, R. and Stein, R
Diabetes, Obesity and Metabolism, vol. 18, pp. 123–127. | Journal Article
 
The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells.
Conrad, Elizabeth⋅Dai, Chunhua⋅Spaeth, Jason⋅Guo, Min⋅Cyphert, Holly A⋅Scoville, David⋅Carroll, Julie⋅Yu, Wei-Ming⋅Goodrich, Lisa V⋅Harlan, David M⋅Grove, Kevin L⋅Roberts, Charles T⋅Powers, Alvin C⋅Gu, Guoqiang and Stein, Roland
American journal of physiology. Endocrinology and metabolism, vol. 310, (no. 1), pp. E91-E102, January 1, 2016. | Journal Article
2015
The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice
Spaeth, J.M.⋅Spaeth, Jason⋅Hunter, C.S.⋅Hunter, Chad⋅Bonatakis, L.⋅Bonatakis, Lauren⋅Guo, M.⋅Guo, Min⋅French, C.A.⋅French, Catherine⋅Slack, Ian⋅Slack, I.⋅Hara, Manami⋅Hara, M.⋅Fisher, S.E.⋅Fisher, Simon⋅Ferrer, Jorge⋅Ferrer, J.⋅Morrisey, Edward⋅Morrisey, E.E.⋅Stanger, Ben⋅Stanger, B.Z.⋅Stein, Roland and Stein, R.
Diabetologia, vol. 58, (no. 8), pp. 1836-1844, Aug 2015. | Journal Article
2014
Uterine Leiomyoma-Linked MED12 Mutations Disrupt Mediator-Associated CDK Activity
Turunen, Mikko⋅Turunen, Mikko⋅Spaeth, Jason M.⋅Spaeth, Jason M⋅Keskitalo, Salla⋅Keskitalo, Salla⋅Park, Min Ju⋅Park, Min Ju⋅Kivioja, Teemu⋅Kivioja, Teemu⋅Clark, Alison D⋅Clark, Alison D.⋅Mäkinen, Netta⋅Mäkinen, Netta⋅Gao, Fangjian⋅Gao, Fangjian⋅Palin, Kimmo⋅Palin, Kimmo⋅Nurkkala, Helka⋅Nurkkala, Helka⋅Vähärautio, Anna⋅Vähärautio, Anna⋅Aavikko, Mervi⋅Aavikko, Mervi⋅Kämpjärvi, Kati⋅Kämpjärvi, Kati⋅Vahteristo, Pia⋅Vahteristo, Pia⋅Kim, Chongwoo A⋅Kim, Chongwoo A.⋅Aaltonen, Lauri A⋅Aaltonen, Lauri A.⋅Varjosalo, Markku⋅Varjosalo, Markku⋅Taipale, Jussi⋅Taipale, Jussi⋅Boyer, Thomas G. and Boyer, Thomas G
Cell Reports, vol. 7, pp. 654–660. | Journal Article
2012
MED12 mutations link intellectual disability syndromes with dysregulated GLI3-dependent Sonic Hedgehog signaling
Zhou, Haiying⋅Spaeth, Jason M.⋅Kim, Nam Hee⋅Xu, Xuan⋅Friez, Michael J.⋅Schwartz, Charles E. and Boyer, Thomas G.
Proceedings of the National Academy of Sciences, vol. 109, pp. 19763–19768. | Journal Article
 
MED12 mutations link intellectual disability syndromes with dysregulated GLI3-dependent Sonic Hedgehog signaling
Zhou, Haiying⋅Spaeth, Jason M.⋅Kim, Nam Hee⋅Xu, Xuan⋅Friez, Michael J.⋅Schwartz, Charles E. and Boyer, Thomas G.
(pp. 19763–19768)
2011
Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet
Krebs, Philippe⋅Krebs, Philippe⋅Krebs, P.⋅Fan, W.⋅Fan, Weiwei⋅Fan, Weiwei⋅Chen, Y.-H.⋅Chen, Yen-Hui⋅Chen, Yen-Hui⋅Tobita, K.⋅Tobita, Kimimasa⋅Tobita, Kimimasa⋅Downes, Michael R⋅Downes, Michael R⋅Downes, M. R.⋅Wood, Malcolm R⋅Wood, M. R.⋅Wood, Malcolm R⋅Sun, L.⋅Sun, Lei⋅Sun, Lei⋅Li, Xiaohong⋅Li, X.⋅Li, Xiaohong⋅Xia, Y.⋅Xia, Yu⋅Xia, Yu⋅Ding, N.⋅Ding, Ning⋅Ding, Ning⋅Spaeth, Jason M⋅Spaeth, J. M.⋅Spaeth, Jason M⋅Moresco, Eva M⋅Moresco, E. M. Y.⋅Moresco, Eva Marie Y⋅Boyer, Thomas G⋅Boyer, T. G.⋅Boyer, Thomas G⋅Lo, C. W. Y.⋅Lo, Cecilia W⋅Lo, Cecilia Wen Ya⋅Yen, Jeffrey⋅Yen, J.⋅Yen, Jeffrey⋅Evans, Ronald⋅Evans, Ronald M⋅Evans, R. M.⋅Beutler, Bruce⋅Beutler, Bruce and Beutler, B.
Proceedings of the National Academy of Sciences, vol. 108, pp. 19678–19682. | Journal Article
 
Mediator and human disease.
Spaeth, Jason M⋅Kim, Nam Hee and Boyer, Thomas G
Seminars in cell & developmental biology, vol. 22, (no. 7), pp. 776-787, September 2011. | Journal Article